modify – Page 23 – Communicable Diseases Research

Phylogenetic analysis of avian infectious bronchitis virus S1 glycoprotein regions reveals emergence of a new genotype in Moroccan broiler chicken flocks

Research

Published on 2015-08-042022-10-28
Journal: Virology Journal [Category] Coronavirus,

Yeast Based Small Molecule Screen for Inhibitors of SARS-CoV

Research Article

Published on 2011-12-022022-10-28
Journal: PLoS ONE [Category] Coronavirus,

[키워드] activities activity Alter bypasse Cell culture cells cellular connection conserved Course demonstrated deubiquitinase Diversity expressed functional growth human coronaviruses induce induction Influenza virus inhibit inhibited inhibiting the function inhibitor inhibitory compounds investigated likelihood mammalian cells mechanism modify molecule Mortality NIH outbreak Papain-like protease phenotype PLP precursor protease Protease activity Replication reservoir Respiratory Coronavirus resulting S. cerevisiae SARS-CoV Screen severe shown small molecule suppressor toxic effect virus replication yeast
[DOI] 10.1371/journal.pone.0028479 PMC 바로가기 [Article Type] Research Article

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

상호 작용을 위한 게놈 와이드 스크린은 총 콜레스테롤에 대한 허리 대 엉덩이 비율의 영향을 수정하는 4p15에 대한 새로운 위치를 밝힙니다.

Research Article

Published on 2011-10-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] A allele adipose Adipose tissue affected affecting allele approach association Author body composition candidate gene cardiovascular diseases CCKAR characterized cholesterol chromosome circulating Cohort collected Concentration conducted contribute dataset demonstrated described differential expression distribution Effect enrichment epidemiological European explain found functions G allele Gene Gene Expression Genetic variant genome-wide association genome-wide significant genomic Genotype genotypes global health GWA Health heritability homozygous identify individual initial Interaction Intervention joint Lipid lipid metabolism lipids loci locus Low-density lipoprotein Low-Density Lipoprotein cholesterol measure Meta-analysis metabolism modify Modifying New open PCDH7 Phenotypes population-based cohort profiles Ratio recent related Replication reported risk risk factor Risk factors Screen screened serum serum lipid Serum lipids Sex Standard deviation tissue Total Total cholesterol Triglyceride triglycerides variant variants waist waist-to-hip ratio WHR
[DOI] 10.1371/journal.pgen.1002333 PMC 바로가기 [Article Type] Research Article

Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex

Research Article

Published on 2011-10-132022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] Analysis antiviral drug assays Author biochemical canonical catalytic catalyzed cellular cofactor complex composed coronavirus demonstrated different Donor drug target drugs ENCODE eukaryotic eukaryotic virus found function Immune escape in viral indicated innate immune insight inter-molecular Interaction methylated methyltransferase modify mRNA mRNA stability mRNAs non-structural protein nsp14 promote protein translation required ribose ribosome RNA RNA stability RNAs S-adenosyl-L-methionine SAM SARS Coronavirus SARS-CoV shown stimulatory Structural analysis subunit subunits unique Viral RNA virus
[DOI] 10.1371/journal.ppat.1002294 PMC 바로가기 [Article Type] Research Article

Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence

Research Article

Published on 2011-06-092022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus infection
[DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article