Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant
Research
[키워드] Amino acid
analyzed
Asian
binding
characterized
Clustal Omega
COVID-19
develop
drug resistance
drugs targeting
England
enzyme
Europe
European
Factors
GenBank database
Genome
genomic sequence
GISAID database
high mutation rate
host immunity
hosts
hydrophobic
include
investigated
Italy
lombardy
median
mortality rates
mutagenic
mutated
Mutation
mutation rate
North
North America
nucleic acids
pandemic
Patient
Phenotypes
Pneumonia
Point mutation
polymerase
predicted
RdRP
RdRp gene
recognize
recurrent mutation
replicate
respiratory
responsible
Result
RNA coronavirus
RNA polymerase
RNA virus
RNA-dependent-RNA-polymerase
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 mutation
SARS-CoV-2 RdRp
SARS-CoV-2 reference genome
SARS-CoV-2 RNA
silent
statistical significance
strain
Treatment
Variability
variant
viral evolution
Viral mutagenesis
virus
was obtained
was performed
were used
[DOI] 10.1186/s12967-020-02344-6 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s12967-020-02344-6 PMC 바로가기 [Article Type] Research