Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19소변의 단백질 및 대사체 프로파일링으로 COVID-19 환자의 면역 반응 밝혀내다Article Published on 2022-01-182022-09-11 Journal: Cell Reports [Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] added analyzed blood lymphocyte blood lymphocyte counts Clinical course complex protein COVID-19 CXCL14 cytokine Cytokines decrease detect disease Diseases downregulation ESCRT ESCRT super-complex healthy controls immune immune response in urine Infectious disease Infectious diseases Inflammation innate immune activation lymphocyte metabolome metabolomic profiling metabolomics modulation multiomics analysis offer other infectious diseases Pathogenesis patients with COVID-19 Protein proteome proteomics receptor renal renal injuries renal injury SARS-CoV-2 replication serum serum sample serum samples severe COVID-19 severity triggered unique Urine utility [DOI] 10.1016/j.celrep.2021.110271 PMC 바로가기 [Article Type] Article
Monolaurin Confers a Protective Effect Against Porcine Epidemic Diarrhea Virus Infection in Piglets by Regulating the Interferon PathwayImmunology Published on 2022-01-132022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] administration Against Analysis antiviral activities caused cytokine response demonstrated diarrhea differentially expressed disease dose Effect epidemic diarrhea evaluate the effect expression group growth homeostasis IL-6 IL-8 Infection inhibited interferon intestinal mechanism monolaurin Mutation no significant effect pathogen pathway Pathways PEDV Piglets Porcine epidemic diarrhea virus Prevent promote promoted protective effect Protein proteomics Regulating Replication Result significantly the interferon virus virus replication [DOI] 10.3389/fimmu.2021.797476 PMC 바로가기 [Article Type] Immunology
Comparative Metabolomics and Proteomics Reveal Vibrio parahaemolyticus Targets Hypoxia-Related Signaling Pathways of Takifugu obscurusImmunology Published on 2022-01-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Bacterial caused cell proliferation Comparative complex conserved Coronavirus disease 2019 COVID-19 Critical defined develop Effect EGF epidermal fibrosis genomic growth growth factor HIF-1α HIF-1α Host host immunity hypoxia include indicated Infection involved liver LRG metabolite metabolomics pathogenic Pathogens Perspective physiological Protein proteomics raise Signal transduction signaling pathway signaling pathways Stressor Takifugu target TGF-β1 TGF-β1 threat tissue damage Vertebrate Vibrio parahaemolyticus widespread [DOI] 10.3389/fimmu.2021.825358 PMC 바로가기 [Article Type] Immunology
Angiotensin-Converting Enzyme Genotype–Specific Immune Response Contributes to the Susceptibility of COVID-19: A Nested Case–Control StudyPharmacology Published on 2022-01-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE acute respiratory syndrome Angiotensin-converting enzyme Chinese complement control group coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 vaccine cytokine Cytokine storm demonstrated detect distribution drug design ELISA kit Genotype global pandemic identify immune immune response lung Mild moderate Odds ratio pathway Patient plasma proteomics polymerase chain polymorphism Precision protein expression proteomics regression analysis response SARS-CoV-2 severe symptom susceptibility [DOI] 10.3389/fphar.2021.759587 PMC 바로가기 [Article Type] Pharmacology
Cytokine Elevation in Severe COVID-19 From Longitudinal Proteomics Analysis: Comparison With Sepsis종단 단백질체학 분석에서 심각한 COVID-19의 사이토카인 상승: 패혈증과의 비교Immunology Published on 2022-01-122022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] “cytokine storm” amphiregulin Analysis association Biomarkers Cohort confidence level contribute coronavirus disease Coronavirus disease 2019 covariate COVID-19 COVID-19 patient Cox proportional hazard Cox proportional hazards model cytokine Cytokine storm Cytokines disease pathogenesis disease severity disease severity of COVID-19 elevated Elevation evaluated GDF-15 growth hazard ratio healthy control healthy controls ICU ICU admission identify IL-6 Inflammation intensive care intensive care unit longitudinal material mechanical ventilation Pathogenesis pathogenesis of COVID-19 patients with COVID-19 plasma plasma protein plasma proteins predicted Prognosis proportional hazards model Proteins proteomics reported Result Sepsis sepsis patient sepsis patients treated uncontrolled unique validation cohort viral disease were measured [DOI] 10.3389/fimmu.2021.798338 PMC 바로가기 [Article Type] Immunology
Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire질량분석법에 의한 차세대 혈청학: SARS-CoV-2 항체 레퍼토리 판독Article Published on 2022-01-072022-09-11 Journal: Journal of Proteome Research [Category] SARS, 진단, 치료기술, [키워드] antibodies antibody Antibody detection Antigen applied Autoimmune disorders B cells capture captures Clonality clone COVID-19 data type degree heavy chains heterogeneity immune response immune responses Immunity immunized Immunoglobulin individual ion mass spectrometry Ion mass mass spectrometry Metrics Mild molecular pathogen Pathogens plasma Protein proteomics RBD Receptor-binding domain Region repertoire SARS-CoV-2 Sequencing serological serology Spike protein subject the receptor-binding domain the SARS-CoV-2 the spike protein titer top-down mass spectrometry. vaccination vaccine doses variable regions [DOI] 10.1021/acs.jproteome.1c00882 PMC 바로가기 [Article Type] Article
Potential Use of Serum Proteomics for Monitoring COVID-19 Progression to Complement RT-PCR DetectionRT-PCR 검출을 보완하기 위한 COVID-19 진행 모니터링을 위한 혈청 단백질체학의 잠재적 사용Article Published on 2022-01-072022-09-11 Journal: Journal of Proteome Research [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] analyzed approach AUC clinic Clinical practice Course COVID-19 COVID-19 patient COVID-19 progression detection diagnose disease course disease course monitoring effort False negative false negatives high risk inactivated Inactivated serum investigated machine learning machine learning model Magnesium mass spectrometry MONITOR monitoring non-severe cases non-severe group nucleic acid Platelet platelet counts Potential practitioners predict promote Protein proteome proteomics regulated required RNA RT-PCR RT-PCR tests serum Serum protein serum sample serum samples Severe case severe cases severe group Swab symptoms onset the disease viral nucleic acid [DOI] 10.1021/acs.jproteome.1c00525 PMC 바로가기 [Article Type] Article
Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites추가: 전사체학 및 단백질체학은 말라리아 기생충 스포로조이트의 성숙 과정에서 두 가지 번역 억제 파동을 밝혀냅니다.Article Published on 2022-01-062024-08-08 Journal: Nature Communications [Category] 말라리아, [키워드] Parasite biology proteomics transcriptomics [DOI] 10.1038/s41467-021-27767-7 PMC 바로가기
Deep Time Course Proteomics of SARS-CoV- and SARS-CoV-2-Infected Human Lung Epithelial Cells (Calu-3) Reveals Strong Induction of Interferon-Stimulated Gene Expression by SARS-CoV-2 in Contrast to SARS-CoVArticle Published on 2022-01-042023-06-14 Journal: Journal of Proteome Research [Category] COVID19(2023년), MERS, SARS, [키워드] coronavirus data-independent acquisition interferon response interferon-stimulated gene proteomics SARS-CoV-2 [DOI] 10.1021/acs.jproteome.1c00783 PMC 바로가기 [Article Type] Article
Pandemic Influenza Infection Promotes Streptococcus pneumoniae Infiltration, Necrotic Damage, and Proteomic Remodeling in the Heart전염병 인플루엔자 감염은 심장에서 폐렴구균 침투, 괴사성 손상 및 단백질체 재구성을 촉진한다.Article Published on 2022-01-042024-07-30 Journal: mBio [Category] 폐렴구균 감염증, [키워드] adhesion heart Influenza necroptosis Pneumolysin pore-forming toxins proteomics Secondary bacterial infections Streptococcus pneumoniae [DOI] 10.1128/mbio.03257-21 PMC 바로가기