A Systematic Review and a Meta-Analysis Comparing Prophylactic and Therapeutic Low Molecular Weight Heparins for Mortality Reduction in 32,688 COVID-19 PatientsPharmacology Published on 2021-09-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% CI 95% confidence interval Activation all-cause mortality anticoagulation bleeding coronavirus disease COVID-19 COVID-19 patients dose effective Effectiveness Efficacy Endpoint evaluated hazard heparin heparin treatment heparins higher risk Hospital stay hospitalized COVID-19 patients increased risk LMWH LOS low molecular weight major bleeding Meta-analysis Mortality no difference Observational cohort study Patient patients performed potential therapy Prophylactic prophylactic dose Randomized controlled trial Ratio RCT reduced reducing mortality Registration reported review SARS-CoV2 secondary subgroup analysis systematic review therapeutic dose Thromboembolism Treatment unfractionated heparin was performed weight [DOI] 10.3389/fphar.2021.698008 PMC 바로가기 [Article Type] Pharmacology
Remdesivir for coronavirus disease 2019 (COVID-19): a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials코로나바이러스 질병 2019(COVID-19)에 대한 렘데시비르: 무작위 대조 시험의 메타 분석 및 시험 순차적 분석을 통한 체계적인 검토Meta-Analysis Published on 2021-09-012022-09-11 Journal: Infectious diseases (London, England) [Category] Coronavirus, SARS, 임상, [키워드] 95% confidence interval addition all-cause mortality calculated conducted controlled trials coronavirus disease COVID-19 diarrhoea Efficacy Evidence evidence of FIVE heterogeneity high risk information Meta-analysis MOST nausea no evidence of occurred outcome outcomes Participants patients progression question random-effects model Randomized Randomized controlled trial Randomized controlled trials RCT RCTs reached Relative risk Remdesivir required risk Safety searched selected sequential analysis Support systematic review Treatment treatment of COVID-19 trial sequential analysis TSA viral burden vomiting [DOI] 10.1080/23744235.2021.1923799 PMC 바로가기 [Article Type] Meta-Analysis
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19Review article Published on 2021-09-012022-10-05 Journal: New Microbes and New Infections [Category] 신약개발, [키워드] animal models Betacoronavirus Committee competitive binding controls correlated COVID-19 death Diseases distribution Efficacy H. pylori indicated Infectious disease Ivermectin mechanism Medicine Meta-analysis morbidity Mortality Mutant strains notable Physiology randomized clinical trial RCT RCTs reduction reductions in risk SARS-CoV-2 SARS-CoV-2 spike protein Seven Sharp Spike protein Treatment tropical yielding [DOI] 10.1016/j.nmni.2021.100924 [Article Type] Review article
Editorial: Reporting Clinical Trials with Important Modifications Due to Extenuating Circumstances, Including the COVID-19 Pandemic: CONSERVE 2021사설: 코로나19 팬데믹: CONSERVE 2021을 포함하여 정상 참작이 가능한 상황으로 인해 중요한 수정 사항이 포함된 임상 시험 보고Editorial Published on 2021-08-302022-09-11 Journal: Medical science monitor : international medical jo [Category] SARS, 임상, [키워드] Analysis clinical clinical trial clinical trials CONSORT COVID-19 COVID-19 pandemic dataset Diseases Drug development editorial feasibility implication IMPROVE include Including Infectious diseases investigators Modification modifications occur oncology other infectious diseases randomized clinical trial RCT RCTs reduce Reporting SARS-CoV-2 vaccine SPIRIT Sponsor Standard Trial trial protocol [DOI] 10.12659/MSM.934514 PMC 바로가기 [Article Type] Editorial
The EPIPHA-KNEE trial: Explaining Pain to target unhelpful pain beliefs to Increase PHysical Activity in KNEE osteoarthritis – a protocol for a multicentre, randomised controlled trial with clinical- and cost-effectiveness analysisStudy Protocol Published on 2021-08-282022-10-27 Journal: BMC Musculoskeletal Disorders [Category] Coronavirus, MERS, SARS, [키워드] activity addition adverse events Analysis Anxiety baseline benefit Blinding clinical Cost-utility analysis COVID-19 Depression determine effective evaluate exercise Explaining finding Follow-up group implementation inactive include increase intensity Intention Intervention knowledge measure multicentre New nine Osteoarthritis outcome outcomes Pain Pain science education parallel-design physical activity physical activity levels Physiotherapy protocol Quality of life randomised controlled trial RCT receive receiving recommendation secondary Self-efficacy sensitivity Strengthening program Stress supplementary material Symptom Total Treatment Trial Walking program [DOI] 10.1186/s12891-021-04561-6 PMC 바로가기 [Article Type] Study Protocol
The EPIPHA-KNEE trial: Explaining Pain to target unhelpful pain beliefs to Increase PHysical Activity in KNEE osteoarthritis – a protocol for a multicentre, randomised controlled trial with clinical- and cost-effectiveness analysisEpipha-Knee 시험 : 무릎 골관절염의 신체 활동을 증가시키기위한 도움이되지 않는 통증 신념을 목표로하는 통증 설명-임상 및 비용 효율성 분석을 통한 다중 센터, 무작위 통제 시험을위한 프로토콜Study Protocol Published on 2021-08-282022-09-10 Journal: BMC Musculoskeletal Disorders [Category] 임상, [키워드] activity addition adverse events Analysis Anxiety baseline benefit best Blinding both groups clinical Controlled trial Cost-utility analysis COVID-19 Depression determine effective evaluate exercise Explaining finding Follow-up followed by general education group implementation inactive include increase intensity Intention Intervention knowledge life measure movement multicentre multicentre randomised controlled trial New nine Osteoarthritis outcome outcomes Pain pain intensity Pain science education parallel-design physical activity physical activity levels Physiotherapy Primary outcomes Program protocol Quality of life randomised controlled trial RCT receive receiving recommendation secondary Secondary outcomes Self-efficacy sensitivity Strengthening program Stress supplementary material Symptom telehealth Total Treatment Trial Two-arm Walking program [DOI] 10.1186/s12891-021-04561-6 PMC 바로가기 [Article Type] Study Protocol
Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trialCOVID-19 호흡기 질환에 대한 안지오텐신 수용체 차단제의 통제된 평가를 위한 프로토콜(CLARITY): 무작위 통제 시험Study Protocol Published on 2021-08-282022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 7-point ordinal scale accumulating ACE2 activities activity adaptive angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme 2 ARB ARBs AT1R Bayesian adaptive design bind blinded blocked CLARITY clinical commenced Controlled Controlled trial COVID-19 COVID-19 severity daily dose death determine disease downregulation Effect Effectiveness enzyme High-risk patients include India interim analysis membrane membrane-bound Mortality offer Open-label Ordinal Scale outcome Placebo Pragmatic Predictive primary endpoint pro-fibrotic pro-inflammatory Probability randomised controlled trial RAS RCT receptor receptor blocker Receptor Blockers recruitment reduce reducing registry Renin renin-angiotensin system respiratory respiratory outcomes responsible Safe Sample size SARS-CoV-2 secondary Secondary outcomes Standard of care supplementary material supply Treatment treatment allocation Trial Trial registration Two-arm [DOI] 10.1186/s13063-021-05521-0 PMC 바로가기 [Article Type] Study Protocol
Grief Reactions and Grief Counseling among Bereaved Chinese Individuals during COVID-19 Pandemic: Study Protocol for a Randomized Controlled Trial Combined with a Longitudinal StudyCOVID-19 전염병 동안 사별한 중국인의 슬픔 반응 및 슬픔 상담: 종단 연구와 결합된 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2021-08-272022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 임상, [키워드] assessment assessments baseline bereavement caused checklist China Chinese Combined complicated grief conducted Controlled controls counseling COVID-19 COVID-19 pandemic DASS DASS-21 death develop disorder DSM-5 effective intervention Effectiveness evaluate grief grief counseling grief reactions health problems help individual individuals initiated Intervention inventory life longitudinal mental health mental health problems mental health service mental health services outcome Posttraumatic growth Primary outcomes Prolonged prolonged grief disorder protocol Psychological PTSD random randomization RCT reaction recruit recruited Research Stress Scale Study protocol trials [DOI] 10.3390/ijerph18179061 PMC 바로가기 [Article Type] Study Protocol
Use of research electronic data capture (REDCap) in a COVID-19 randomized controlled trial: a practical exampleCOVID-19 무작위 대조 시험에서 연구 전자 데이터 캡처 (REDCAP) 사용 : 실제 예Research Article Published on 2021-08-212022-09-10 Journal: BMC Medical Research Methodology [Category] Fulltext, MERS, SARS, 임상, [키워드] allocation sequence Antibody test Blinding can be used capture changed Complete component conducted confidentiality Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 Data collection defect Efficacy eligibility example feature Follow-up investigator investigators lab Longitudinal data offer parallel group powerful tool Protective protocols randomization Randomized Randomized controlled trials RCT RCTs receiving recruitment REDCap Registered Registration registration number reported Research Research Electronic Data Capture researcher Result Risk of bias SARS-CoV-2 antibody test secure supplementary material test results treatment arm Trial registration unique university web application XML [DOI] 10.1186/s12874-021-01362-2 PMC 바로가기 [Article Type] Research Article
Internet-based stress recovery intervention FOREST for healthcare staff amid COVID-19 pandemic: study protocol for a randomized controlled trialCOVID-19 대유행 중 의료진을 위한 인터넷 기반 스트레스 회복 개입 FOREST: 무작위 통제 시험을 위한 연구 프로토콜Study Protocol Published on 2021-08-212022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] affected Anxiety Care CBT complex conducted contribute Control COVID-19 COVID-19 pandemic Depression Detachment Effect Efficacy Follow-up forest HCWs healthcare Healthcare staff healthcare worker Healthcare workers Injury Internet-Based Intervention internet-based interventions Intervention Keeping Mental mental health mental healthcare Mindfulness-based Moral injury Nurses offered outcome parallel group Psychological well-being PTSD Randomized controlled trial RCT reduce Relaxation Sleep Stress Stress recovery Study protocol Support Trial registration [DOI] 10.1186/s13063-021-05512-1 PMC 바로가기 [Article Type] Study Protocol