Molecular Epidemiology Analysis of SARS-CoV-2 Strains Circulating in Romania during the First Months of the PandemicArticle Published on 2020-08-142022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] adopted affected Analysis Asia B.1.1 circulating Cluster coronavirus detect distribution Epidemic Europe European country event France global public health initiated Italy limit Lineage Local lockdown measure molecular Molecular epidemiology Month Mutation mutations outbreak pandemic performed Phylogenetic Phylogenetic analysis profile Region respiratory Romania Russia SARS-CoV-2 SARS-CoV-2 viral sequence Sequencing Spain specific mutations Spread strain suggested Switzerland the epidemic Transmission transmissions Turkey viral strain WGS [DOI] 10.3390/life10080152 PMC 바로가기 [Article Type] Article
ACEI/ARB therapy in COVID-19: the double-edged sword of ACE2 and SARS-CoV-2 viral dockingResearch Letter Published on 2020-07-312022-11-01 Journal: Critical Care [Category] COVID-19, SARS, [키워드] ACE2 ACEI/ARB therapy COVID-19 docking SARS-CoV-2 viral therapy [DOI] 10.1186/s13054-020-03195-9 PMC 바로가기 [Article Type] Research Letter
ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of Cushing’s syndromeClinical Practice Guidance Published on 2020-07-202022-10-31 Journal: European Journal of Endocrinology [Category] COVID-19, [키워드] Care clinical clinical feature country COVID-19 Cushing’s syndrome Diagnosis diagnostic feasible feature Health Immunocompromised immunosuppressed patients individual initiated less Local maintain management measure Mild moderate pandemic pathway Patient patients Pituitary Prevalence Prognosis recommendation reduce repeated risk of infection SARS-CoV-2 SARS-CoV-2 viral significantly social distancing social isolation Treatment urgent investigation [DOI] 10.1530/EJE-20-0352 PMC 바로가기 [Article Type] Clinical Practice Guidance
Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19SARS-CoV, SARS-CoV-2 및 SARS-CoV-2 전 세계 분리주 사이의 후성유전 조절자 miRNA 패턴 차이로 팬데믹 COVID-19의 서사적 병원성과 독특한 임상적 특징 뒤에 숨겨진 미스터리Genetics Published on 2020-07-102022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] alleviate anomalies Anomaly antiviral miRNAs autophagy binding breathing complications cardiovascular diseases cellular miRNA cellular pathway clinical Comorbidities Complication computational approach Computational approaches country COVID-19 COVID-19 patients death death rates diabetes difference disease effective epigenetic modulator epigenetic regulator experiments Factors functional Gene Expression Host host antiviral miRNA host genes host immunity host miRNA host's miRNAs human cell IFN-I IFN-I signaling immune regulation immune-escape mechanism immune-signaling pathways implication isolate latency lead Microarray miRNA miRNA clusters miRNA-mediated interaction miRNA-microRNA miRNAs mode modulate molecular mechanism Neutralizing normalized over representation analysis Pathogenesis Pathways patients with comorbidity pattern predict predicted profile regulator RNA therapeutics RNA-Seq SARS virus SARS viruses SARS-CoV SARS-CoV and SARS-CoV-2 viral miRNAs SARS-CoV and SARS-CoV-2 viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 miRNAs SARS-CoV-2 pathogenesis SARS-CoV-2 viral SARS-CoV-2 virus SARS-infected human cell microarray signaling pathways Support symptoms of COVID-19 target targets the SARS-CoV-2 Viral viral miRNA viral miRNAs viral pathogenesis viruses [DOI] 10.3389/fgene.2020.00765 PMC 바로가기 [Article Type] Genetics
p38 MAPK inhibition: A promising therapeutic approach for COVID-19Short communication Published on 2020-07-012022-10-05 Journal: Journal of molecular and cellular cardiology [Category] SARS, 신약개발, [키워드] ACE2 activating Activation acute lung injury angiotensin Angiotensin II angiotensin-converting enzyme 2 attenuate caused clinical trial convert COVID-19 COVID-19 infection downregulating downregulation explained expressed homology IL-6 implicated induce Infection Inflammation inflammatory effect Inflammatory response inhibitor inhibitory Loss lung MAPK mechanism mechanisms morbidity and mortality Myocardial dysfunction p38 MAPK pathway pro-inflammatory cytokine pro-thrombotic proinflammatory promote protective effect replicate Replication respiratory virus RNA SARS-CoV SARS-CoV-2 SARS-CoV-2 viral second serious COVID-19 shown Signaling the SARS-CoV-2 virus Therapeutic approach upregulated viral entry Viral protein [DOI] 10.1016/j.yjmcc.2020.05.007 [Article Type] Short communication
Predicted peptide patterns from the SARS-CoV-2 proteome for MS-MS based diagnosisResearch Article Published on 2020-06-302022-10-28 Journal: Bioinformation [Category] COVID-19, [키워드] 2019 novel coronavirus Analysis biological fluid body fluid can be used caused complex COVID-19 dataset Diagnosis early diagnosis Health manifested nasopharyngeal swabs pandemic PCR peptide platform proteome SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 viral Skyline targeted proteomics the SARS-CoV-2 the WHO tryptic peptides Variability viral mutation virus [DOI] 10.6026/97320630016477 PMC 바로가기 [Article Type] Research Article
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성Article Published on 2020-05-212022-09-10 Journal: Biomedicines [Category] 비임상, [키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website [DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article
Plasma CRP level is positively associated with the severity of COVID-19Research Published on 2020-05-152022-10-28 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] COVID-19, MERS, [키워드] 95% CI applied assist association Biomarker Care characterized chest pain Computed tomography contagious coronavirus disease cough COVID-19 CRP CRP level CT enrolled Fever group help indicated Inpatient Laboratory Linear regression model management guideline marker Mild mild pneumonia moderate nucleic acid Patient performed physician plasma CRP Pneumonia positively correlated predict Protein qRT-PCR Ratio Result SARS-CoV-2 SARS-CoV-2 viral Severe COVID-19 pneumonia severe pneumonia severity severity of COVID-19 the disease the patient transfer [DOI] 10.1186/s12941-020-00362-2 PMC 바로가기 [Article Type] Research
Detection of SARS-CoV-2 RNA and Antibodies in Diverse Samples: Protocol to Validate the Sufficiency of Provider-Observed, Home-Collected Blood, Saliva, and Oropharyngeal SamplesProtocol Published on 2020-04-242022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, SARS, [키워드] accountability Act acute respiratory syndrome alternative method approved Care clinical decision coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical detection diagnostic effective effort engage enrolled Evidence flexible Health IMPROVE in viral include Infection Infectious disease institutional review board insurance IRB Laboratory testing lack limitation measure Nasopharyngeal swab NPs objective observation outbreak pandemic participant Participants Patient PCR Personal protective equipment PPE protocol public health Public health response Public health responses reagents Result RNA-PCR Sample SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral Serologic response serology specimen specimens Swab Telemedicine Testing the United State Transport media university validation [DOI] 10.2196/19054 PMC 바로가기 [Article Type] Protocol
Interpret with caution: An evaluation of the commercial AusDiagnostics versus in-house developed assays for the detection of SARS-CoV-2 virusArticle Published on 2020-04-202022-11-01 Journal: Journal of Clinical Virology [Category] COVID-19, SARS, [키워드] applied AusDiagnostics AusDiagnostics assay clinical sample clinical samples collected CoV-229E CoV-NL63 COVID-19 COVID-19 case COVID-19 infection Culture E gene Endemic gBlocks influenza A influenza B Integrated DNA Technologies laboratory confirmation M genes Multiplex PCR nasopharyngeal aspirate NAT NATs Negative predictive value nose and throat nucleic acid test ORF1ab ORF1b other respiratory virus PCR assay positive positive control positive result RdRP RdRp gene resolved respiratory virus respiratory viruses Result rhinovirus RSV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SARS-CoV-2 virus sensitivity Sequencing serial dilution significantly lower specificity sputum swabs tested viral culture was collected [DOI] 10.1016/j.jcv.2020.104374 PMC 바로가기 [Article Type] Article