The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral TreatmentArticle Published on 2020-06-012023-06-14 Journal: Current Neurovascular Research [Category] MERS, SARS, [키워드] AKT AMP activated protein kinase (AMPK) angiotensin converting enzyme 2 Apoptosis autophagy Coronaviruses COVID-19 Cytokines Diabetes Mellitus Inflammation Influenza interferons Interleukins macrophage inflammatory protein 1-α (MIP-1α) mechanistic target of rapamycin (mTOR) metformin monocyte chemoattractant protein 1 (MCP-1) mTOR Complex 1 (mTORC1) mTOR Complex 2 (mTORC2) oxidative stress SARS-CoV-2 tumor necrosis factor-α virion [DOI] 10.2174/1567202617666200425205122 PMC 바로가기 [Article Type] Article
The management of patients with metastatic prostate cancer during the COVID-19 pandemicSpecial Report Published on 2020-05-152022-10-31 Journal: Future Oncology [Category] COVID-19, MERS, SARS, [키워드] approach benefit Cancer castrate resistant Cell Chemotherapy coronavirus coronavirus disease COVID-19 COVID-19 in patient COVID-19 infection COVID-19 pandemic Deprivation facilitate global pandemic hormone sensitive immune system Immunosuppression inhibited management men metastatic pandemic Patient patients Patients with cancer Prostate cancer raise receive Replication risk serine proteases therapy TMPRSS2 virion weighed [DOI] 10.2217/fon-2020-0361 PMC 바로가기 [Article Type] Special Report
A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19)Infectious Disease Published on 2020-04-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE ACE2 Angiotensin-converting enzyme ARDS Basic science Biochemistry can be used candidate CDC center Chloroquine clinical Clinical course Clinical practice clinical trial Comprehensive Control Coronavirus disease 2019 Corticosteroid COVID-19 COVID19 described diagnostic discharge disease course epidemiological evaluate evaluated Evolution experiment explain Factor Frequency global pandemic H1N1 hindrance hospital ibuprofen Infection information inhibitors limitation literature literature review LOPINAVIR AND RITONAVIR management manuscript media MERS Micronutrient mRNA-1273 vaccine multiple parameter nonsteroidal anti-inflammatory drug NSAIDS outbreak pandemic Phylogeny presentation Prophylaxis Public health interventions remdesivir (GS-5734) review risk factor SARS-CoV-2 self-quarantine severe acute respiratory infection Spread statistical Stratification Symptom the SARS-CoV-2 virus the WHO therapy Treatment viral genome virion Vitamin C [DOI] 10.7759/cureus.7560 PMC 바로가기 [Article Type] Infectious Disease
Identification of a novel B-cell epitope in the spike protein of porcine epidemic diarrhea virusResearch Published on 2020-04-032022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] 3D structure anorexia antibodies antibody Antisera B-cell epitope BALB/c mice cause characterized demonstrated detect determine Diagnostic method ELISA ENhance epidemic diarrhea epitope Epitopes generate high mortality identification identify IFA immunization immunize immunized mice immunodominant indicated Infection Infectious disease linear mAb monoclonal antibodies monoclonal antibody Neonatal Neutralizing Neutralizing antibodies PEDV peptide polyclonal polyclonal antibodies Protein purified reactivity receptor recognize Recombinant protein Region required residue Result S protein S1 protein Spike protein the spike protein Vaccine design virion virus vomiting was used weight loss were used western blot [DOI] 10.1186/s12985-020-01305-1 PMC 바로가기 [Article Type] Research
Ginkgolic acid inhibits fusion of enveloped virusesArticle Published on 2020-03-162022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] Activation acute infection addition Adenovirus Administered AMPK antivirals Astrocyte CMV decreased expression DNA Ebola virus EBV Effect Epstein Barr virus Escherichia coli experiment fatty fusion protein genome replication Ginkgo biloba HCMV herpes simplex virus Herpes virus HIV HSV-1 Human Cytomegalovirus IAV impairment in vitro Infection influenza A virus inhibit initial Invasion lesion mechanism Membrane biophysics non-specific phosphatase pleiotropic effect Post-infection Protein Replication reported shown Staphylococcus aureus suggested synaptic treat Treatment viral infection Viral protein virion virus Zika virus ZIKV [DOI] 10.1038/s41598-020-61700-0 PMC 바로가기 [Article Type] Article
PEDV enters cells through clathrin-, caveolae-, and lipid raft-mediated endocytosis and traffics via the endo-/lysosome pathwayResearch Article Published on 2020-02-102022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] addition antiviral drugs Cell cells cellular cellular entry characterized cholesterol classical coronavirus described economic loss endocytic pathways Entry mechanism epidemic diarrhea gene sequence Guidance highest highly pathogenic information Invasion involved lysosome mechanisms mutant strain Pathogenesis pathogenicity pathway Pathways PEDV provided reached Research strain Strains target Transport variant Vero Cell Vero cells virion virus were used [DOI] 10.1186/s13567-020-0739-7 PMC 바로가기 [Article Type] Research Article
The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of NeurotropismArticle Published on 2019-10-222022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Adsorption condition coronavirus CoVs determinant effective Encephalitis Essential Evidence experiment furin cleavage site furin-S2′ site fusion peptide Genotype IBV in vitro in vivo induce Infectious Bronchitis Virus Mortality mutant neurotropism neutralization pathogenicity QX type S2′ site serum spike Spike protein Symptom the spike protein upstream Vaccine virion virus wild-type [DOI] 10.3390/v11100972 PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus spike protein counteracts BST2‐mediated restriction of virus‐like particle releaseResearch Article Published on 2019-07-102022-11-01 Journal: Journal of medical virology [Category] Coronavirus, SARS, [키워드] acute respiratory syndrome alleviate Antiviral association BST2 Cell cellular coronavirus coronavirus spike protein counteract Degradation determine downregulate downregulating downregulation experiment Factor Factors glycoprotein glycosylation human coronavirus 229E Human immunodeficiency virus immune responses Infection inhibit Innate immunity lysosomal ORF7a Particle Particles pathway Pathways proteasomal reduce reduced reported required SARS Coronavirus Spike protein Support target virion virus virus classification virus replication viruses [DOI] 10.1002/jmv.25518 PMC 바로가기 [Article Type] Research Article
Characteristics of the Life Cycle of Porcine Deltacoronavirus (PDCoV) In Vitro: Replication Kinetics, Cellular Ultrastructure and Virion Morphology, and Evidence of Inducing AutophagyArticle Published on 2019-05-182022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] affected Alpha Analysis autophagy beta-coronavirus cause cells cellular Characteristics cycle cytoplasm described diarrhea electron microscopy evidence of genomic RNA help in vitro indicated Inducing Infection infectious titer Kinetics life membrane molecular mechanism morphology p62 porcine deltacoronavirus (PDCoV) Replication replication kinetics Structure ultrastructure Vesicle virion vomiting [DOI] 10.3390/v11050455 PMC 바로가기 [Article Type] Article
Hepatitis B virus core protein dimer‑dimer interface is critical for viral replicationArticle Published on 2019-01-012023-06-16 Journal: Molecular medicine reports [Category] B형 간염, [키워드] capsid core protein dimer-dimer interface hepatitis B virus Replication virion [DOI] 10.3892/mmr.2018.9620 PMC 바로가기