Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells폐 상피 세포를 과발현하는 SARS-CoV-2 코딩 서열의 세포외 소포로 처리한 후 인간 iPSC 심근세포에서 바이러스 RNA 단편 검출Letter Published on 2020-11-302022-09-10 Journal: Stem Cell Research & Therapy [Category] SARS, 치료기술, [키워드] A549 ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cardiomyocytes cardiovascular risk factors caused coding sequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable detection direct viral infection epithelial cells Evidence evidence of EVs expression extracellular vesicle Extracellular vesicles global pandemic heart Human iPSCs lung epithelial cell Lung epithelial cells overexpressed overexpressing Patient pluripotent stem cell-derived cardiomyocytes receptor reported respiratory SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes SARS-COV-2 infection SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus stem cells supplementary material Treatment upregulation Viral viral gene viral genes viral genome viral infection Viral RNA viral RNA fragment [DOI] 10.1186/s13287-020-02033-7 PMC 바로가기 [Article Type] Letter
Clinical characteristics on admission predict in-hospital fatal outcome in patients aged ≥75 years with novel coronavirus disease (COVID-19): a retrospective cohort studyResearch Article Published on 2020-11-302022-10-27 Journal: BMC Geriatrics [Category] COVID-19, [키워드] 95% CI 95% confidence interval Admission age body temperature Characteristics clinical Clinical characteristics consecutive patient coronavirus disease COVID-19 patient creatinine critical cases D-dimer death died discharged elderly fatality female Fever Final Follow-up hospital hs-TNI identify In-hospital In-hospital death independent risk factor Laboratory lactic dehydrogenase LDH lymphocyte median age medical records N-terminal novel novel coronavirus disease NT-proBNP observation Odds ratio outcome oxygen saturation Patient peptide Platelet predict prediction reduced Result retrospective cohort study risk factor SARS-CoV-2 sensitivity Sex supplementary material troponin I worldwide pandemic [DOI] 10.1186/s12877-020-01921-0 PMC 바로가기 [Article Type] Research Article
Different types of physical activity are positively associated with indicators of mental health and psychological wellbeing in rheumatoid arthritis during COVID-19Observational Study Published on 2020-11-302022-10-04 Journal: Rheumatology International [Category] MERS, SARS, 임상, [키워드] activity analogue Analysis association COVID-19 COVID-19 complications depressive depressive symptom diet Effect examined exercise fatigue form Hierarchical inventory LIGHT limit Linear regressions lockdown LPA Mental mental health Moderation Pain Patient physical physical activity populations Psychological questionnaire rheumatoid arthritis risk SARS-CoV-2 scale sedentary behaviour sedentary time Self-isolation significantly Subjective supplementary material Symptom United Kingdom Visual vitality walking was related [DOI] 10.1007/s00296-020-04751-w PMC 바로가기 [Article Type] Observational Study
Clinical characteristics on admission predict in-hospital fatal outcome in patients aged ≥75 years with novel coronavirus disease (COVID-19): a retrospective cohort studyResearch Article Published on 2020-11-302022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, SARS, [키워드] 95% CI 95% confidence interval Admission age body temperature Characteristics clinical Clinical characteristics consecutive patient coronavirus disease COVID-19 patient creatinine critical cases D-dimer death died discharged elderly fatality female Fever Final Follow-up hospital hs-TNI identify In-hospital In-hospital death independent risk factor Laboratory lactic dehydrogenase LDH lymphocyte median age medical records N-terminal novel novel coronavirus disease NT-proBNP observation Odds ratio outcome oxygen saturation Patient peptide Platelet predict prediction reduced Result retrospective cohort study risk factor SARS-CoV-2 sensitivity Sex supplementary material troponin I worldwide pandemic [DOI] 10.1186/s12877-020-01921-0 PMC 바로가기 [Article Type] Research Article
A randomized, multicentre, open-label phase II proof-of-concept trial investigating the clinical efficacy and safety of the addition of convalescent plasma to the standard of care in patients hospitalized with COVID-19: the Donated Antibodies Working against nCoV (DAWn-Plasma) trialCOVID-19로 입원한 환자의 표준 치료에 회복기 혈장 추가의 임상 효능과 안전성을 조사하는 무작위, 다기관, 공개 라벨 2상 개념 증명 시험: nCoV에 대항하는 기증된 항체(DAWn- 플라즈마) 시험Clinical Trial Published on 2020-11-272022-08-13 Journal: Trials [Category] SARS, 임상, 진단, [키워드] absence active treatment addition administration Belgium Bronchoalveolar lavage Clinical efficacy clinical status convalescent plasma COVID-19 infection COVID-19 pandemic defined diagnosed with COVID-19 Diagnosis diagnosis of COVID-19 died Effect eligible feature Health care Health care system health care systems Hospitalized hospitalized patient hospitalized patients Immunity include Infection Influenza information Intervention mechanical ventilation Mortality multicentre nCoV novel SARS-CoV-2 virus Open-label Ordinal Scale past Patient patients hospitalized PCR primary endpoint proof-of-concept clinical trial proportion radiological randomization Randomized receive recruit Registered Safe SARS-CoV-2 virus secondary endpoint Standard of care study inclusion supplementary material Support Swab symptomatic the disease the WHO Treatment treatment group Trial Trial registration with COVID-19 working [DOI] 10.1186/s13063-020-04876-0 PMC 바로가기 [Article Type] Clinical Trial
Risk factors for mortality in hospitalized patients with COVID-19 at the start of the pandemic in Belgium: a retrospective cohort studyResearch Article Published on 2020-11-272022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] age Analysis Belgium Care Chinese Clinical characteristics cohorts Complication coronavirus coronavirus disease country COVID-19 COVID-19 patient death described Diagnosis effective Europe European Factor Fatality rate good quality Hospitalized hospitalized COVID-19 patients hospitalized patient identify in-hospital mortality increased risk intensive care Invasive mechanical ventilation IQR lactate dehydrogenase lower mortality male Mortality Most patient multivariate logistic regression Older age outcome pandemic Patient patients with obesity predictor preventative measures renal Result retrospective cohort study risk factor severe disease supplementary material the epidemic the median therapeutic United State Univariate analysis with COVID-19 [DOI] 10.1186/s12879-020-05605-3 PMC 바로가기 [Article Type] Research Article
Mental health of clinical staff working in high-risk epidemic and pandemic health emergencies a rapid review of the evidence and living meta-analysisReview Published on 2020-11-272022-10-28 Journal: Social psychiatry and psychiatric epidemiology [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] 95% CI acute respiratory syndrome added analysis code Anxiety baseline COVID-19 COVID-19 pandemic cut-off Depression Ebola Epidemic Evidence H1N1 influenza Health health emergency infected patients management measure mental health mental health problem mental health service MERS Meta-analysis Middle East outbreak pandemic poor mental health Prevalence PTSD raised random effect Result SARS-CoV-2 staff supplementary material syndrome Total [DOI] 10.1007/s00127-020-01990-x PMC 바로가기 [Article Type] Review
Evidence for treatment with estradiol for women with SARS-CoV-2 infectionResearch Article Published on 2020-11-252022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] 95% CI ACE2 acute respiratory syndrome administration age age and gender Analysis analyzed both sexes cellular entry changed coronavirus coronavirus disease COVID-19 COVID-19 cohort COVID-19 patient death Effect effective Electronic health record estradiol estradiol therapy expression Factor fatality Fatality rate female hazard ratio Hormone treatment human Angiotensin-converting enzyme incidence Infection influence International Kaplan-Meier survival curve men outcomes pre-menopausal women Predictive Primary outcome propensity score matching Prospective Study protective role Protein receiving reduced Result Retrospective study risk risk of COVID-19 risk of infection SARS-CoV-2 SARS-COV-2 infection Sex significantly higher sub-cohort supplementary material susceptibility therapeutic therapy Treatment was performed while women [DOI] 10.1186/s12916-020-01851-z PMC 바로가기 [Article Type] Research Article
The impact of caring for dying patients in intensive care units on a physician’s personhood: a systematic scoping reviewResearch Published on 2020-11-252022-10-29 Journal: Philosophy, Ethics, and Humanities in Medicine : P [Category] Coronavirus, SARS, [키워드] Abstract adopted Analysis article Care conditions coping strategies COVID-19 pandemic Critical Death and dying dying patient ENhance evaluate evaluated Evidence ICU ICUs Impact independent individual information Innate intensive care unit intensive care unit (ICU) mechanism Nurse Personhood physician Physicians reproducibility Resilience Result Ring Ring theory of personhood (RToP) split SSR supplementary material Support Supporting thematic analysis theory [DOI] 10.1186/s13010-020-00096-1 PMC 바로가기 [Article Type] Research
Remote continuous glucose monitoring during the COVID-19 pandemic in quarantined hospitalized patients in Denmark: A structured summary of a study protocol for a randomized controlled trial덴마크의 격리된 입원 환자에서 COVID-19 전염병 동안 원격 연속 혈당 모니터링: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Randomized Controlled Trial Published on 2020-11-252022-09-01 Journal: Trials [Category] SARS, 임상, 진단, 치료기술, [키워드] 1:1 able to communicate addition Admission age Analysis association band-aid blinded blood glucose blood glucose monitoring calibrated Care CGM Clinical outcome clinically Confirmed COVID-19 infection Contact contagious disease contagious diseases contagious infection contagious infections Controlled trial COVID-19 COVID-19 infected patient COVID-19 infection COVID-19 pandemic Date defined detect diabete diabetes diabetes - diabetes management Diagnosis Diagnostic Criteria dissemination distribution element Endpoint enrolled exclusion criteria exploratory female Finger prick form Glucose glucose control glycaemic control group groups Healthcare provider Hospitalization Hospitalized hospitalized patient hypersensitivity Hypothesis Identifier Improved In-hospital Inclusion inclusion criteria increased risk infected patients Infection infections Informed consent management masking MONITOR mounted must Non-COVID-19 not need number objective open open label outcome parallel group participant Patient patients with diabete performed Pneumonia PPE primary endpoint protocol quarantine randomisation randomised randomised controlled trial randomization randomization list Randomized Randomized controlled trial Real-time PCR recorded reduce remote reported required risk Sample size SARS-COV-2 infection secondary Secondary endpoints service stratified Study protocol subject supplementary material the patient the primary endpoint transmitted Trial trial protocol Trial registration Type 1 diabetes type 2 diabetes variable website World Health Organization written Informed Consent [DOI] 10.1186/s13063-020-04872-4 PMC 바로가기 [Article Type] Randomized Controlled Trial