Rapid and High-Throughput Reverse Transcriptase Quantitative PCR (RT-qPCR) Assay for Identification and Differentiation between SARS-CoV-2 Variants B.1.1.7 and B.1.351SARS-CoV-2 변이체 B.1.1.7 및 B.1.351 간의 식별 및 분화를 위한 신속하고 높은 처리량의 역전사효소 정량적 PCR(RT-qPCR) 분석Research Article Published on 2021-10-062022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition Alpha variant B.1.1.7 B.1.351 Beta variant clinical sample clinical samples Complete COVID-19 pandemic Decision making detect Diagnosis diagnostic differential PCR differentiation effort epidemiological epidemiological studies Epidemiological study facilitate help identification identify Illumina sequencing in vitro Laboratory Lineage Lineage B.1.1.7 lineages molecular diagnostics molecular virology multiplex Mutation Pathogens PCR public health quantitative PCR Rapid Rapid diagnosis reaction Real-time PCR Research respiratory respiratory pathogen Respiratory pathogens reverse transcriptase RNA RNA extraction RT-qPCR Sanger sequencing SARS-CoV-2 SC-2 variants scaled up sensitivity Sequencing specificity Spread strain transcribed transcriptase utilization Vaccine variant variant B.1.1.7 variant B.1.351 variants Viral Viral RNA Virology was determined was tested whole-genome sequencing [DOI] 10.1128/Spectrum.00506-21 PMC 바로가기 [Article Type] Research Article
Averting an Outbreak of SARS-CoV-2 in a University Residence Hall through Wastewater Surveillance폐수 감시를 통해 대학 기숙사에서 SARS-CoV-2 발생 방지Research Article Published on 2021-10-062022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] (alpha administration Alpha Alpha variant Alpha VOC approach B.1.1.7 Campus Clinical data Community COVID-19 COVID-19 infection decision estimate Evidence evidence of example fecal individual Infection laboratory-confirmed MONITOR Moore North America outbreak over positive positive result public health quantitative PCR quarantine reported residence response reverse transcriptase RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screening programs spring Surveillance Swab tested transcriptase triggered universities university variant VoC was collected wastewater wild-type Wuhan strain [DOI] 10.1128/Spectrum.00792-21 PMC 바로가기 [Article Type] Research Article
Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infectionsSARS-COV-2 델타 변형의 전염 사건은 다수의 백신 혁신 감염을 보여줍니다.Research Article Published on 2021-10-012022-09-10 Journal: BMC Medicine [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allele allergy Alpha Alpha variant Amplicon Analysis B.1.617.2 BNT162b2 causal variant Chain Reaction circulating SARS-CoV-2 variants Cluster college coronavirus COVID-19 delta variant described determine filtered fraction funding GATK Genome global public health highest identify immune evasion Infection Infectious disease Infectious diseases Medicine Moderna mRNA-1273 nasopharyngeal swabs Panel Part Patient Pfizer polymerase chain polymerase chain reaction qPCR Quantitative quantitative polymerase chain reaction respiratory Result reveal risk SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 strain SARS-CoV-2 variant sequenced Sequencing severe acute respiratory syndrome Coronavirus supplementary material supported Swab tested toolkit Transmissibility Vaccine vaccine breakthrough infection variant Viral [DOI] 10.1186/s12916-021-02103-4 PMC 바로가기 [Article Type] Research Article
A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency사량체 ACE2 단백질은 상승된 효능으로 우려되는 SARS-CoV-2 스파이크 변이체를 광범위하게 중화합니다Article Published on 2021-10-012022-09-11 Journal: Antiviral Research [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 protein ACE2-Fc addition Alpha Alpha variant angiotensin angiotensin converting enzyme B.1.1.7 B.1.351 Beta variant binding can not coronavirus COVID-19 dimeric elevated enzyme greater high affinity neutralization neutralize Pandemics Protein pseudotype virus SAR2-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein SARS-CoV-2 spike proteins SARS-CoV-2 spike variant SARS-CoV-2 variants South Africa spike Spike protein tetravalent the SARS-CoV-2 therapeutic approaches United Kingdom vaccination variant variant spike Variant spike. variants of concern VoC [DOI] 10.1016/j.antiviral.2021.105147 PMC 바로가기 [Article Type] Article
[COVID-19: epidemiology and mutations : An update][COVID-19: 역학 및 돌연변이 : 업데이트]Review Published on 2021-10-012022-09-11 Journal: Radiologe [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Alpha variant antibody antibody treatment approach AstraZeneca B.1.1.28.1 B.1.1.7 B.1.351 B.1.617 bamlanivimab Beta variant Brazil caused circulating coronavirus Course courses decrease delta variant described disease severity dominant Effectiveness English ENhance Epidemiology fatal disease Germany herd immunity Immunity India Infection infectiousness Kingdom less life-threatening Mild moderate disease monoclonal antibodies monoclonal antibody mortality risk Mutation mutations neutralization ability offer outcome P.1 pandemic protective effect rule SARS-CoV-2 SARS-CoV‑2 severe acute respiratory syndrome Coronavirus South Africa Spread symptomatic disease the disease the vaccine vaccination vaccination rate Vaccinations Vaccine variant variants virus strain virus variants wild type [DOI] 10.1007/s00117-021-00909-0 PMC 바로가기 [Article Type] Review
Case Report of COVID-19 after Full Vaccination: Viral Loads and Anti-SARS-CoV-2 AntibodiesCase Report Published on 2021-09-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Alpha variant Analysis anti-SARS-CoV-2 antibodies antibody B.1.1.7 COVID-19 demonstrated effective vaccine expected immune responses indicated Infection load manifested mild COVID-19 symptoms mRNA vaccine Prevent produced report reported SARS-CoV-2 SARS-CoV-2 lineage sore throat Stage Viraemia viral genome sequence Viral load viral loads virus with COVID-19 [DOI] 10.3390/diagnostics11101815 PMC 바로가기 [Article Type] Case Report
Key Interacting Residues between RBD of SARS-CoV-2 and ACE2 Receptor: Combination of Molecular Dynamics Simulation and Density Functional CalculationSARS-CoV-2의 RBD와 ACE2 수용체 간의 주요 상호 작용 잔류물: 분자 역학 시뮬레이션과 밀도 함수 계산의 조합Article Published on 2021-09-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 변종, [키워드] ACE2 ACE2 receptor Alpha Alpha variant Amino acid Analysis atomic level Beta Beta variant bind binding binding free energy calculation complex density Density functional theory determine domain driving Dynamics E484K electrostatic ENhance free energy functional hotspot hydrogen hydrophobic hydrophobic interaction identify implementation increase K417N molecular molecular dynamics Molecular mechanics molecular target N501Y N501Y mutation performed predict presenting proliferation protocol RBD RBD of SARS-CoV-2 RBD-ACE2 Receptor-binding domain reduce residue responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS2 significantly Simulation Spike protein surface area Tight binding Vaccine development variant variants virus infection wild-type [DOI] 10.1021/acs.jcim.1c00560 PMC 바로가기 [Article Type] Article
Rapid reinfection with SARS-CoV-2 variant-of-concern Alpha detected in a nurse during an outbreak at a non-covid inpatient ward: lessons learned비 코비 입원 환자 병동에서 발생하는 동안 간호사에서 감지 된 SARS-COV-2 변형 알파를 사용한 빠른 재감염 : 학습 한 교훈Short Report Published on 2021-09-262022-09-10 Journal: Antimicrobial Resistance and Infection Control [Category] SARS, 변종, 치료기술, [키워드] Alpha Alpha variant attack rate Care Cluster epidemiological Infection Infection control guidelines Infection prevention and control nine Nosocomial transmission Nurse occur outbreak Outbreak investigation Patient patient family phylogenetically positive Primary infection Rapid Reinfection SARS-CoV-2 second Sequencing tested Transmissibility Transmission university hospital variant Viral [DOI] 10.1186/s13756-021-01008-4 PMC 바로가기 [Article Type] Short Report
A Barcoded Flow Cytometric Assay to Explore the Antibody Responses Against SARS-CoV-2 Spike and Its VariantsSARS-CoV-2 스파이크 및 그 변이체에 대한 항체 반응을 조사하기 위한 바코드 유세포 분석 분석Immunology Published on 2021-09-232022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] accumulate Against Alpha Alpha variant B cell Beta Beta variant boost cell line characteristic chimeric color coronavirus COVID-19 COVID-19 patient COVID-19 patients E484K effort evaluate expressed expression Flow flow cytometric flow cytometry fusion protein generate Health Health crisis higher affinity human immune response human population humoral immune response Humoral immunity IgA class IgG IgG response Immune escape immune response less life-threatening lymphoma mutant Mutation N501Y Pneumonia Point mutation Protein protocol RBD receptor ACE2 receptor-binding domains reduce expression response S protein SARS-CoV-2 SARS-CoV-2 pandemic serum antibody severe disease manifestation spike Spike protein Spread spread to the patient the receptor-binding domain this new coronavirus vaccination variant variant of SARS-CoV-2 variants variants of SARS-CoV-2 Viral viral entry virus virus variants wild type WT S [DOI] 10.3389/fimmu.2021.730766 PMC 바로가기 [Article Type] Immunology
Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamstersSARS-CoV-2 Alpha 변이체의 저용량 접종은 햄스터의 이전 변이체보다 더 효율적으로 전달합니다.Article Published on 2021-09-202022-09-10 Journal: Communications Biology [Category] SARS, 변종, [키워드] Alpha Alpha variant B.1.1.7 circulating D614G demonstrated dose effective exhibit experimental evidence explain hamster hamsters Human In-vitro Infection key factor lack Lineage low dose lower dose nasal Nasal cavity observé other variant other variants parental replicate SARS-CoV-2 short duration shown Spread strain Transmission Transmission model underlie variant variant of SARS-CoV-2 variants of SARS-CoV-2 Viral Viral transmission [DOI] 10.1038/s42003-021-02640-x PMC 바로가기 [Article Type] Article