binding site – Page 24 – Communicable Diseases Research

TGEV infection up-regulates FcRn expression via activation of NF-κB signaling

Article

Published on 2016-08-242022-10-29
Journal: Scientific Reports
[Category] Coronavirus,

SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway

Article

Published on 2016-05-132022-10-29
Journal: Scientific Reports
[Category] Coronavirus,

Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27

Article

Published on 2015-08-182022-10-29
Journal: Scientific Reports
[Category] Coronavirus,

Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin
[DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article

Cell adhesion as a novel approach to determining the cellular binding motif on the severe acute respiratory syndrome coronavirus spike protein

Article

Published on 2014-02-132022-11-01
Journal: Journal of virological methods
[Category] Coronavirus,

[키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome against SARS-CoV Amino acid analyses approach binding Binding motif binding site caused Cell cellular coronavirus spike protein determine Effect H7N9 Influenza life threatening MERS-CoV Middle East motif MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide pathogen peptide Peptide inhibitor Psychological RBD, receptor-binding domain RBM, receptor-binding motif required residues respiratory syndrome coronavirus S, spike Safe SARS-CoV SARS-CoV spike protein SARS-CoV, severe acute respiratory syndrome-coronavirus Spike protein synthetic peptide the spike protein Therapeutic approach vaccine candidate VERO E6 cells
[DOI] 10.1016/j.jviromet.2014.01.022 PMC 바로가기 [Article Type] Article

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

MicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다

Research Article

Published on 2013-02-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while
[DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article

The Murine Coronavirus Hemagglutinin-esterase Receptor-binding Site: A Major Shift in Ligand Specificity through Modest Changes in Architecture

Research Article

Published on 2012-01-262022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus,

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

Research Article

Published on 2011-08-222022-10-28
Journal: PLoS ONE
[Category] Coronavirus, MERS,

Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis

인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다

Research Article

Published on 2011-06-232022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type
[DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article

Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel

Research Article

Published on 2009-07-102022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus,

[키워드] 2003 acute respiratory syndrome affecting alteration Anti-viral drugs antiviral strategy Author binding site C-terminal Cell channel characterized common cold coronavirus coronavirus coronavirus protein described determined distribution drug design E protein embryonic kidney envelope envelope protein event expressed expressing feature form found full length HEK-293 Human humans in vitro inactivation infect inhibited inhibition Ion lethal disease mammalian cell mammals membrane Mild morphology N-terminal NMR pandemic Pathogenesis pharmacological target platform produced Protein Proteins provide reduced reported responsible SARS-CoV SARS-CoV E shown significantly Structure supported transmembrane domain Validity variety viral envelope viral pathogen viral replication virion virus viruses
[DOI] 10.1371/journal.ppat.1000511 PMC 바로가기 [Article Type] Research Article