Drug repurposing – Page 24 – Communicable Diseases Research

Computational drug repurposing for the identification of SARS-CoV-2 main protease inhibitors

SARS-CoV-2 주요 프로테아제 억제제 식별을 위한 컴퓨터 약물 용도 변경

Article

Published on 2021-10-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발,

In silico drug repurposing in COVID-19: A network-based analysis

Covid-19의 Silico Drug Reperhing에서 : 네트워크 기반 분석

Article

Published on 2021-10-012022-08-31
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, 신약개발, 임상, 치료제,

Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2

COVID-19 : SARS-COV-2의 주요 프로테아제 (MPRO)를 사용한 구조적 연구

Article

Published on 2021-10-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, 치료제,

[키워드] active site best calculate Cangrelor caused Cobicistat Compound computational studies conditions contrast agent Corona Corona virus COVID 19 COVID-19 COVID-19 disease database docking drug drug candidate Drug repurposing drug target drugs effective effective drug effective drugs enzyme FDA approved drug Fortovase global pandemic Gromacs health emergency HIV hour identification imperative inhibitor Iopromide majority MD simulation molecular molecular docking studies Molecular docking study MPro non-structural protein non-structural proteins outbreak pandemic performed processing protease SARS-CoV-2 SARS-CoV-2 virus stability the disease the SARS-CoV-2 virus translated treating COVID-19 Viral Viral RNA Virtual screening virus while Zinc ZINC database
[DOI] 10.1080/07391102.2020.1798286 PMC 바로가기 [Article Type] Article

SGLT2-Inhibition reverts urinary peptide changes associated with severe COVID-19: An in-silico proof-of-principle of proteomics-based drug repurposing

SGLT2-억제는 심각한 COVID-19와 관련된 요로 펩티드 변화를 되돌립니다: 프로테오믹스 기반 약물 용도 변경의 인-실리코 증거

Article

Published on 2021-10-012022-09-11
Journal: Proteomics [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 진단,

In silico identification of widely used and well-tolerated drugs as potential SARS-CoV-2 3C-like protease and viral RNA-dependent RNA polymerase inhibitors for direct use in clinical trials

임상 시험에서 직접 사용하기위한 잠재적 인 SARS-COV-2 3C- 유사 프로테아제 및 바이러스 RNA- 의존성 RNA 중합 효소 억제제로서 널리 사용되고 내성 된 약물의 실리코 확인에서

Article

Published on 2021-10-012022-08-31
Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, 치료제,

[키워드] 3 chymotrypsin like protease 3CL pro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approved approved drug Azithromycin binding free energies Bromocriptine chymotrypsin clinical trial clinical trials clinically conivaptan coronavirus coronavirus disease Coronavirus disease 2019 dihydroergotamine docking results drug drug library Drug repurposing dutasteride Eltrombopag enzyme Enzymes Ergotamine evaluate food high affinity Hydroxychloroquine in silico inhibitor initial Interaction issue MD simulation measure molecular molecular dynamics nelfinavir paliperidone persistence physiological conditions protease RdRP repurposing RNA RNA dependent RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2-infected patients searched selected severe acute respiratory syndrome Coronavirus Tetracycline tipranavir Treatment Viral RNA viral RNA-dependent RNA polymerase
[DOI] 10.1080/07391102.2020.1802346 PMC 바로가기 [Article Type] Article

Repurposing functional inhibitors of acid sphingomyelinase (fiasmas): an opportunity against SARS-CoV-2 infection?

산 스 핑고 마이 엘리나 제 (Fiasmas)의 기능적 억제제를 재구성 : SARS-COV-2 감염에 대한 기회?

Review

Published on 2021-10-012022-08-31
Journal: Journal of clinical pharmacy and therapeutics [Category] SARS, 신약개발,

Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation

강력한 C형 간염 바이러스 프로테아제 억제제인 Asunaprevir, SARS-CoV-2 전파 차단

Article

Published on 2021-09-302022-09-11
Journal: Molecules and cells [Category] SARS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity asunaprevir binding block blocked calu-3 cells candidate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytopathic effect cytopathic effects daclatasvir direct-acting antiviral Drug repurposing evaluated Health hepatitis C hepatitis C virus human lung human lung Calu-3 cells include infected cells inhibited inhibitor life cycle NS5A pandemic potent Propagation Protease inhibitor protein level protein levels RNA RNA polymerase inhibitor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 vaccine SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus significantly sofosbuvir therapeutic agent Treatment vaccination Vero E6 VERO E6 cells viral life cycle virion
[DOI] 10.14348/molcells.2021.0076 PMC 바로가기 [Article Type] Article

Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestations

Research article

Published on 2021-09-292022-10-05
Journal: Heliyon [Category] 신약개발,

Rapid growth in the COVID-19 era

Review Article

Published on 2021-09-292022-10-30
Journal: Mrs Bulletin [Category] COVID-19,

Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium

인간기도 상피에서 SARS-COV-2 유도 유전자 시그니처의 통합 메타 분석에 기초한 COVID-19에 대한 약물 용도

Research Article

Published on 2021-09-282022-09-10
Journal: PLoS ONE [Category] SARS, 신약개발, 치료제,

[키워드] activated acute respiratory syndrome Algorithm Algorithms ALPL Anti-viral approved Biomarker candidate canonical CCL20 CLC clinical trial clinical trials coronavirus coronavirus 2 COVID-19 COVID-19 pathogenesis COVID-19 treatment CSF3 CXCL1 CXCL10 CXCL8 database differentially expressed gene drug Drug repurposing drug target drugs effective intervention epithelial cells FDA gene network gene networks gene signature Genomics Human airway epithelium IL6 independent indications Infection inflammatory pathways information Ingenuity Pathway Analysis inhibit IPA list log2FC Meta-analysis pathway primary human airway Primary human airway epithelial cells Protein Qiagen regulate respiratory RNA sequencing SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus severe acute respiratory syndrome-related coronavirus 2 target targets Treatment Trial
[DOI] 10.1371/journal.pone.0257784 PMC 바로가기 [Article Type] Research Article