Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virusArticle Published on 2019-09-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] aminopeptidase Analysis Antigen APN Biological techniques caused Cell Cloning Coronaviruses described disease Diseases economic loss embryonic lethal enteric disease epidemic diarrhea epithelial cell gastroenteritis host cell in vitro Infection lack lesion measure Mortality Neonatal normal pregnancy nuclear PEDV produced producing provide putative receptor reported small intestine small intestines susceptible target tissue TGEV thought transfer viability viral challenge virulent virus wildtype [DOI] 10.1038/s41598-019-49838-y PMC 바로가기 [Article Type] Article
Lessening of porcine epidemic diarrhoea virus susceptibility in piglets after editing of the CMP-N-glycolylneuraminic acid hydroxylase gene with CRISPR/Cas9 to nullify N-glycolylneuraminic acid expressionResearch Article Published on 2019-05-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] age biallelic Cas9 clinical manifestation clinical symptom colostrum cytoplasm Deceased detectable diarrhoea died Epidemic epithelial cell euthanized exhibited experiments expression Glucose Health homozygous hpi Hypothesis immune immunofluorescence infect Infection inoculated intestine moderate mRNA mutated occurred Occurrence offered offspring PEDV replaced severity single-guide RNA staining susceptibility TCID two group vacuolization villus virus was tested wild-type [DOI] 10.1371/journal.pone.0217236 PMC 바로가기 [Article Type] Research Article
Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype구강 인두 감염 동안 Candida albicans 삼염색체를 선택하면 공생 유사 표현형이 나타납니다.Research Article Published on 2019-05-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Acute stress adhere Affect allelic Alter amplification analyzed antifungal agents Author benefit Candida Candida albican Candida albicans caused change Characteristics chromosome chromosomes clone clones commensal conserved de novo de novo mutation de novo mutations determine diploid elicited epithelial cell epithelial cells exhibited exposure to expression facilitate Frequency functional fungal fungal pathogen fungal pathogens fungus Genome growth Host host response in vitro in vivo Infection Inflammatory Interaction isolate killing less Lineage mice MOST mouse model much higher mutations neutrophil oral infections Oropharyngeal Pathogens phenotype Phenotypes Post-infection proliferate recognize reduced respond selected Selection significantly significantly lower strain Strains subsequent susceptibility These data tongue trisomy virulence weight loss while Whole genome sequencing [DOI] 10.1371/journal.pgen.1008137 PMC 바로가기 [Article Type] Research Article
Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex VivoArticle Published on 2019-01-092023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] epithelial cell Influenza lung Macrophage mouse model RNA sequencing [DOI] 10.1128/JVI.01986-18 PMC 바로가기
Transferrin receptor 1 is a supplementary receptor that assists transmissible gastroenteritis virus entry into porcine intestinal epitheliumResearch Published on 2018-10-202022-10-31 Journal: Cell Communication and Signaling : CCS [Category] Coronavirus, [키워드] age Anemia antibody assist blocked Caco-2 cell cell line Clustering diarrhea down-regulated epithelial cell expressed expression Extracellular gastroenteritis Hypothesis infect Infection inhibited interact intestinal epithelium Invasion investigated IPEC-J2 cells mechanism mortality rate Newborn over-expressed primary target cell promoted Protein receptor Replication Result S1 protein significantly supplementary material Support TGEV transferrin receptor 1 transmissible gastroenteritis virus viral infection virus entry vomiting [DOI] 10.1186/s12964-018-0283-5 PMC 바로가기 [Article Type] Research
Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4Article Published on 2018-06-272022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] accompanied addition analyzed Cell ciliary Coronavirus infections demonstrated Dipeptidyl peptidase 4 disease DPP4 eight epithelial cell expressed expressing expression level Health highlight histology immunofluorescence immunohistochemistry immunolabeling Infection information investigated lack lymphocyte Macrophage macrophages manifestation MERS MERS-CoV MERS-CoV infection Microscopy Middle East Monocytes nasal turbinate outcome Pathogenesis patients PBS positive cells post infection promote receiving recent Respiratory disease source of infection surface receptor syndrome T cells tissue vaccination viral cell virus virus entry [DOI] 10.1038/s41598-018-28109-2 PMC 바로가기 [Article Type] Article
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeletonarticle Published on 2018-01-312024-09-01 Journal: EMBO Reports [Category] 세균성이질, [키워드] ARF1 ArfGAP1 epithelial cell Mycobacterium tuberculosis phospholipase D1 [Article Type] article
A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4Research Article Published on 2017-08-152022-10-31 Journal: Computational and Mathematical Methods in Medicine [Category] Coronavirus, MERS, [키워드] attack bronchiolar cause caused cells coronavirus defined Describing Dipeptidyl peptidase 4 DPP4 dynamic endothelial epithelial cell expressed expression humans Infection MERS MERS-CoV Middle East Model novel pathogen peptidase receptor Respiratory system severe pneumonia shown Spread stability syndrome [DOI] 10.1155/2017/5285810 PMC 바로가기 [Article Type] Research Article
Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory virusesResearch Article Published on 2017-06-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 24 hours antiviral genes approach can be used caused Cell cellular response changes changes in coronavirus Defense dependent on disease Effect elicited epithelial cell expression Gene Expression Host host gene expression host response hours post-infection in vitro study in vivo Infection influenza A virus lung epithelial cell Lung epithelial cells mechanism mice microarray analysis Mild moderate mounted murine overlapping parameters Pathogenesis peaked respiratory tract respiratory viral infection respiratory viral infections respiratory virus response rhinovirus severity signature tissue remodeling transcription factor transcriptional Treatment type I interferon unique virus virus infection viruses [DOI] 10.1371/journal.pone.0178408 PMC 바로가기 [Article Type] Research Article
Tissue Distribution of the MERS-Coronavirus Receptor in BatsArticle Published on 2017-04-262022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] bat bats Dipeptidyl peptidase-4 distribution DPP4 epithelial cell Eptesicus expression highlight Human humans infect intestinal tract MERS-CoV Middle East occur Pathogenesis Pipistrellus receptor reflect reported respiratory syndrome coronavirus respiratory tract respiratory tract tissue Rousettus shown suggested susceptible tissue Transmission Variability virus [DOI] 10.1038/s41598-017-01290-6 PMC 바로가기 [Article Type] Article