Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main ProteaseResearch Article Published on 2015-12-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis Asian assessment catalysis catalytic activity Coronaviral coronavirus correlation country CoV Critical demonstrated domain domain III enzyme European Fatality rate FIVE highly pathogenic indicate investigated Jeddah M pro MERS MERS-CoV Middle East monomer Mutagenesis Mutation peptide protease Protein proteolytic activity provide required residue respiratory syndrome coronavirus Result Saudi Arabia spread to ultracentrifugation virus wild-type [DOI] 10.1371/journal.pone.0144865 PMC 바로가기 [Article Type] Research Article
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targetsArticle Published on 2015-12-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated Analysis Antiviral antiviral response antiviral responses antiviral signaling Asia binding contribute coronavirus country cytoplasm cytoplasmic determinant Europe evade highly pathogenic IFN IFN-α/β IFN-β IKKε inhibit Interaction interferon IRF3 IκB MAVS MDA5 mechanism MERS-CoV Middle East mitochondrial molecular interaction Mortality North nuclear nuclear localization signal nucleus ORF4b other coronavirus Pathogenesis pathogenicity Phosphorylation previous study Protein Regulatory respiratory syndrome coronavirus RIG-I shown significantly spread to subsequent suppress TANK target TBK1 the interferon therapeutic Type I IFN type I interferon virulence virus [DOI] 10.1038/srep17554 PMC 바로가기 [Article Type] Article
Human coronaviruses in severe acute respiratory infection (SARI) cases in southwest IndiaShort Communication Published on 2015-10-292022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] absence Acute respiratory infection aetiology all age group Community conducted Conventional coronavirus cross HCoV HCoV 229E highly pathogenic HKU1 Human human coronavirus human coronaviruses Inc India Laboratory MERS morbidity and mortality NL63 OC43 Patient PCR assays Periodicals Prevalence real time reported respiratory respiratory sample retrospective SARI SARS southwest India tested throat swabs viral respiratory infection virus [DOI] 10.1002/jmv.24296 PMC 바로가기 [Article Type] Short Communication
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative CrossResearch Article Published on 2015-10-092022-10-28 Journal: PLoS Genetics [Category] Coronavirus, [키워드] Animal host animal model approach assist candidate gene chromosome classical complex contribute contributing to disease disease severity E3 ubiquitin ligase evaluate fiber Genes Genetic genetic data Genetic variation genetics genome region Health highly pathogenic Host host gene identification identify Inflammation Inflammatory response knockout mice loci locus Lung pathology mice microbial mouse model New Noncoding RNAs outcome outcomes pathogen Pathogenesis Pathogens pathology phenotype phenotypic platform populations regulate resource respiratory viruses responses SARS patient SARS-CoV SARS-CoV infection single gene Spread statistical susceptibility loci the disease traits transcriptomic data utility Vascular viral titer virus replication viruses weight loss were used [DOI] 10.1371/journal.pgen.1005504 PMC 바로가기 [Article Type] Research Article
Influenza A(H5N8) Virus Similar to Strain in Korea Causing Highly Pathogenic Avian Influenza in GermanyArticle Published on 2015-05-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Germany H5N8 subtype highly pathogenic Influenza influenza A virus poultry viruses wild birds zoonoses [DOI] 10.3201/eid2105.141897 PMC 바로가기
Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin VariantArticle Published on 2015-05-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Avian Influenza clade 2.3.4 Evolution H5N1 hemagglutinin highly pathogenic HPAI Influenza monophyletic group rapid emergence reassortant reassortment events subtype variant virulent viruses [DOI] 10.3201/eid2105.141927 PMC 바로가기
An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titrationResearch Article Published on 2015-03-152022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Administered caused Cell culture Complete Culture demonstrated diarrhea disease dose Efficacy ELISA enzyme-linked immunosorbent Epidemic epidemic diarrhea evaluate experimental design FIVE fluorescent foci Genome sequencing help highly pathogenic humoral immune response identity immunoassay immunogenic immunogenicity inactivated Inactivated vaccine infective intramuscularly log microsphere monovalent vaccine negative controls Neutralization assay nucleotide PEDV performed pig Porcine Protective responses Result selected sera significantly higher strain TCID tissue vaccinate Vaccine vaccine candidate virus [DOI] 10.1186/s12917-015-0357-1 PMC 바로가기 [Article Type] Research Article
Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolatesResearch Article Published on 2014-12-222022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] Activation acute respiratory syndrome Amino acid Analysis analyzed approach Atypical Calu-3 caused Cell cell line changes changes in clinical Clustering Computational topology coronavirus Cytokine simulation differential expression epithelial Extracellular feature filtered Gene Expression highly pathogenic homology host response human airway epithelial human Calu-3 humans IFN IL-1α in viral include Infection innate immune Innate immunity isolate kinetic magnitude MERS MERS-CoV MERS-CoV infection Middle East modulate Novel coronavirus pathogenic patients performed persistence Pneumonia post infection pro-inflammatory pro-inflammatory responses progressive respiratory failure Protein respiratory virus responses Result SARS-CoV Signaling STAT3 statistical analysis strain Strains supplementary material syndrome TNF transcriptional transcriptional change transcriptional difference transcriptomics zoonotic [DOI] 10.1186/1471-2164-15-1161 PMC 바로가기 [Article Type] Research Article
Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expressionArticle Published on 2014-11-262022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accumulating acute respiratory syndrome antiviral responses biological function common conserved coronavirus CoV CoV infection CoVs determine downregulation Evidence Factor function functional highly pathogenic Host host gene expression human coronavirus inhibit innate immune response knowledge mammalian Middle East modulate mRNA cleavage nonstructural protein 1 novel nsp1 Pathogenesis Protein provide Regulation RNA viruses SARS SARS Coronavirus syndrome translation inhibition unique Vaccine development viral gene expression Viral protein virulence [DOI] 10.1016/j.virusres.2014.11.019 PMC 바로가기 [Article Type] Article
Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirusArticle Published on 2014-10-162022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] activity Biochemistry capping complex coronavirus coronavirus RNA CoVs enzyme exonuclease Factors function Genome highlighting highly active highly pathogenic in vitro insight involved mechanism mechanisms MERS-CoV methyltransferase Middle East Molecular biology positive-sense Proofreading provided replicate Replication Research respiratory RNA RNA polymerase RNA synthesis RNA virus RNA-dependent RNA polymerase SARS Coronavirus SARS-coronavirus SARS-CoV single-stranded stimulated unique [DOI] 10.1016/j.virusres.2014.10.008 PMC 바로가기 [Article Type] Article