Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2Full Paper Published on 2020-10-162022-10-31 Journal: ChemMedChem [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antiviral activity Antiviral agents Benzamide binding mode Cell culture Computational chemistry coronavirus CoV cysteine protease cytotoxicity drug design highlight homologous Infection inhibit inhibition inhibitor inhibitors Isoindoline Pathogens protease protease inhibitors relationship Replication SAR SARS‐CoV‐2 shown similarity starting point Structure-activity relationships target proteases treat [DOI] 10.1002/cmdc.202000548 PMC 바로가기 [Article Type] Full Paper
Highly conserved binding region of ACE2 as a receptor for SARS-CoV-2 between humans and mammalsBrief Report Published on 2020-09-292022-10-28 Journal: The Veterinary Quarterly [Category] COVID-19, MERS, SARS, [키워드] accelerate ACE2 ACE2 protein acute respiratory syndrome addition Amino acid Analysis angiotensin-converting enzyme 2 antiviral therapeutics appear binding binding region Complete conserved coronavirus COVID-19 FIVE food homologous homology Human human ACE2 humans infected with SARS-CoV-2 Infection information Interaction involved mammal Medical countermeasures mink Multiple sequence alignment Nature New York peptide Phylogenetic tree Precision Protein protein regions Quality RBD receptor Receptor binding domain reduced reported residue risk SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD SARS-CoV-2 transmission sequence spike glycoprotein structural homology Support the SARS-CoV-2 three-dimensional structure transmitted USA Vaccine design virus was used were infected World Health Organization [DOI] 10.1080/01652176.2020.1823522 PMC 바로가기 [Article Type] Brief Report
The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus InfectionsImmunology Published on 2020-08-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV Anti-viral drugs clinical disease clinical feature Comparative coronavirus COVID-19 Cytokine storm disease dysfunction Evidence exhibit homologous immunological characteristics immunology Immunopathogenesis immunopathology Immunotherapy Infection knowledge mechanism MERS MERS-CoV Novel coronavirus pandemic Pathogenesis pathogenesis of COVID-19 pathogenicity patients recent finding Research responsible SARS-CoV SARS-CoV-2 Stage the disease therapeutic strategy Transmissibility Vaccines virus [DOI] 10.3389/fimmu.2020.02033 PMC 바로가기 [Article Type] Immunology
Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting ImplicationsArticle Published on 2020-08-132022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] 3D structure ACE2 acetylcholine receptors agonist Amino acid cell entry cell receptors cholinergic COVID-19 COVID-19 patients docking experiment domain dysregulation enzyme examined Extracellular form homolog homologous hospitalized COVID-19 patients Hypothesis identification implicated Inflammation Interaction modelled structure molecular neurotoxin Nicotine Nicotinic Cholinergic System observation pathophysiology performed Potential Prevalence PROTECT raise receptor SARS-CoV-2 sequence smoking spike subunit System targeting the SARS-CoV-2 the Spike therapeutic toxin virus while [DOI] 10.3390/ijms21165807 PMC 바로가기 [Article Type] Article
Structure-Based Drug Design of an Inhibitor of the SARS-CoV-2 (COVID-19) Main Protease Using Free Software: A Tutorial for Students and Scientistspreprint Published on 2020-08-122022-10-31 Journal: ChemRxiv [Category] COVID-19, [키워드] AutoDock coronavirus COVID-19 disseminate drug drug candidate drug design experimental validation Free help homologous information inhibitor Interaction M pro modify molecular docking pandemic Pandemics peptide Peptide inhibitor protease provide SARS Coronavirus SARS-CoV SARS-CoV M SARS-CoV-2 scientist structure-based design structures student supplementary material the SARS-CoV-2 tutorial UCSF Chimera X-ray X-ray crystallographic structure [DOI] 10.26434/chemrxiv.12791954 PMC 바로가기 [Article Type] preprint
Endogenization and excision of human herpesvirus 6 in human genomes인간 게놈에서 인간 헤르페스바이러스 6의 내생성 및 절제Research Article Published on 2020-08-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affecting association childhood chromosome chromosome 22q chromosomes contribute described direct repeats Diseases DRs East Asians Evolution excision expected explain Genome genome sequence Genome sequences germline germlines HHV-6 HHV-6A HHV-6B homologous Human Human genome Human genomes human herpesvirus 6 humans in vivo infect Infectious virus integration Japan Japanese Japanese people leads life locus MOST MOV10L1 nuclear physically PIWI-interacting RNAs polymorphism Polymorphisms question raise Reactivation Recombination reported required risk RNA screened sequence sequences solo-DR subject subtelomere telomere telomeres transposons variant Viral viral genome viral reactivation virus WGS whole-genome sequencing [DOI] 10.1371/journal.pgen.1008915 PMC 바로가기 [Article Type] Research Article
Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19세파란틴: COVID-19에서 일본 승인 탈모증 약물의 항바이러스 가능성 검토Review Published on 2020-07-222022-09-10 Journal: Pharmacological Reports [Category] MERS, SARS, 신약개발, 치료제, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Against Anti-inflammatory Antioxidative antiparasitic Antiviral antiviral agent antiviral properties approved candidate caused Cepharanthine choice clinically combating coronavirus coronavirus inhibitor COVID-19 COVID-19 cases Cyclooxygenase cytokine cytokine production demonstrated drug drug of choice Evidence expression Hayata homologous immunomodulating Inflammatory response inhibit lipid peroxidation NF-κB nitric oxide nuclear Replication respiratory SARS-CoV-2 Stephania suppresse therapeutic therapeutic potential unique Viral viral entry viral replication virus viruses [DOI] 10.1007/s43440-020-00132-z PMC 바로가기 [Article Type] Review
Rapid Quantification of SARS-CoV-2-Neutralizing Antibodies Using Propagation-Defective Vesicular Stomatitis Virus PseudotypesArticle Published on 2020-07-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome analyzed antibodies antiviral therapy approved biosafety Biosafety Level 3 can be used caused classical coefficient convalescent COVID-19 patient convalescent COVID-19 patients coronavirus correlated detect determine displaying genus Betacoronavirus homologous Immune status morbidities MOST neutralization titer neutralized Neutralizing antibodies neutralizing antibody Neutralizing antibody titer pandemic virus passive immunization patient cohort Pearson correlation performed pseudotype virus pseudovirus quantification Rapid robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody sera serum Spike protein the SARS-CoV-2 therapeutic vaccinated individuals Vaccine Vaccines vesicular vesicular stomatitis virus VSV [DOI] 10.3390/vaccines8030386 PMC 바로가기 [Article Type] Article
Pathogenic characteristics of a QX-like infectious bronchitis virus strain SD in chickens exposed at different ages and protective efficacy of combining live homologous and heterologous vaccinationResearch Article Published on 2020-07-082022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] age Characteristics characterized chicken circulating clinical observations Combination demonstrated distribution Efficacy evaluated experiment Genotype help Heterologous homologous homology IBV Infection infections Infections bronchitis virus Infectious Bronchitis Virus Injury Isolation occurred ovarian oviduct pathogenic pathogenicity predominant Protective reproductive Strains tissue tracheal vaccination Vaccine Vaccines variant virus [DOI] 10.1186/s13567-020-00811-y PMC 바로가기 [Article Type] Research Article
Analysis of ACE2 Gene-Encoded Proteins Across Mammalian SpeciesVeterinary Science Published on 2020-07-032022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] ACE2 ACE2 gene acute respiratory syndrome Analysis analyzed angiotensin-converting enzyme 2 binding caused chronic disease close contact coded coronavirus coronavirus disease correlation COVID-19 Data analysis Felis homologous homology host cell Human human ACE2 receptor humans immunosuppressive Infection infection process mammalian mammals novel Novel coronavirus Pneumonia predicted Predictive Protein public health Rattus receptor required SARS-CoV-2 Specy spike-protein suggested susceptibility susceptible Transmission virus [DOI] 10.3389/fvets.2020.00457 PMC 바로가기 [Article Type] Veterinary Science