Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replicationSARS-CoV-2에 대한 기도 상피 인터페론 반응은 리노바이러스보다 열등하고 이종 라이노바이러스 감염은 SARS-CoV-2 복제를 억제합니다Article Published on 2022-04-282022-09-11 Journal: Scientific Reports [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] addition AEC airway airway epithelial cell airway epithelial cells airway epithelium alphacoronavirus Betacoronavirus biosafety level Biosafety Level 3 bronchial BSL-3 cell lysate cell lysates children common Concentration correlated Culture cultures CXCL10 Delta delta variant Donor elicit epithelial epithelial cells evade Ex vivo experiment Gene Expression generate greater heterogeneity Heterologous highly pathogenic HRV IFN IFN response IFN-β IFN-λ IFNB1 induce Infection interferon interferon response less level 3 Older omicron Protein recombinant IFN recombinant IFN-β reduce reduced replicated response responses rhinovirus RNA robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication significantly subset supernatant suppresse Treatment type I variant variants viral replication was collected were infected [DOI] 10.1038/s41598-022-10763-2 PMC 바로가기 [Article Type] Article
Revisiting the Mongolian Gerbil Model for Hepatitis E Virus by Reverse GeneticsArticle Published on 2022-04-272023-06-11 Journal: Microbiology Spectrum [Category] E형 간염, Fulltext, [키워드] antivirals Hepatitis E virus (HEV) Innate immunity interferon Mongolian gerbil reverse genetics [DOI] 10.1128/spectrum.02193-21 PMC 바로가기
Cytokines from Bench to Bedside: A Retrospective Study Identifies a Definite Panel of Biomarkers to Early Assess the Risk of Negative Outcome in COVID-19 Patients벤치에서 병상까지 사이토카인: 코로나19 환자에서 음성 결과의 위험을 조기에 평가하기 위한 확실한 바이오마커 패널을 확인하는 후향적 연구Observational Study Published on 2022-04-272022-09-11 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 임상, [키워드] affected age anti-inflammatory response Bench best Biomarker Biomarkers C-reactive protein conducted correlations COVID-19 COVID-19 patient COVID-19 patients CRP cut-off cytokine Cytokines death Definite disease pathogenesis Endothelial dysfunction explain Extensive help Hospital admission Hospitalized identify IL-10 IL-1β IL-6 IL-8 immunoparalysis interferon interferon-γ interleukin interleukin 6 Intervention intubation IP10 majority marker mortality rate MR-proADM negative observational study orotracheal intubation outcome Panel Patient performed Predictive Predictive value proadrenomedullin Prognosis representing retrospective risk severe patients sIL2Rα. Stage statistical analysis synergy systemic inflammation tested TNFα variable worse prognosis [DOI] 10.3390/ijms23094830 PMC 바로가기 [Article Type] Observational Study
Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccinationSARS-CoV-2에 대한 백신 유도 체액 반응은 급격히 감소했지만 세포 면역은 BNT162b2 백신 접종 후 6개월까지 유지되었을 가능성이 있습니다.Article Published on 2022-04-262022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 50% neutralization titer 95% CI 95% confidence interval age alcohol alcohol consumption BNT162b2 Cell cell count Cell-mediated immunity cellular immunity completion coronavirus coronavirus disease coronavirus disease-2019 correlated declined dose elevated ELISPOT ELISpot assay evaluate evaluated Gender geometric mean geometric mean titer geometric mean titers healthy subject humoral IgG Immunoglobulin Immunoglobulin G interferon interferon-γ Interferon-γ releasing ELISpot assay median age neutralization neutralization titer neutralizing antibody of BNT162b2 parameter patients remained SARS-CoV-2 SARS-CoV-2 spike protein SFC Spike protein subjects vaccination vaccine-induced antibodies vaccine-induced antibody variant variant of concern [DOI] 10.1016/j.vaccine.2022.03.057 PMC 바로가기 [Article Type] Article
Viral and cellular translation during SARS‐CoV‐2 infectionReview Published on 2022-04-252023-06-16 Journal: FEBS Open Bio [Category] COVID19(2023년), MERS, SARS, [키워드] immune response interferon NSP1‐SL1 ribosome SARS‐CoV‐2 translation [DOI] 10.1002/2211-5463.13413 PMC 바로가기 [Article Type] Review
Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including OmicronArticle Published on 2022-04-212023-06-14 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, [키워드] Immunity interferon omicron Pathogenesis RNA sequencing SARS-CoV-2 therapy [DOI] 10.1016/j.celrep.2022.110799 PMC 바로가기 [Article Type] Article
Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별Article Published on 2022-04-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absolute neutrophil count Analysis Aritficial Intelligence biochemical biochemical markers Biochemical parameters Blood urea nitrogen C-reactive protein clinical Cohort control subject control subjects coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical curated cytokine Cytokines dataset differential expression disease severities Efficacy exploratory ferritin granzyme B highlight identify identifying IFN-γ IL-1 IL-10 IL-15 IL-1ra IL-6 immunological Increased Initially interferon Interferon-gamma interleukin investigated Lactate lactate dehydrogenase Liver injury machine machine learning methodology modeling multiplex Multiplex assay Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Necrosis neutrophil nitrogen outcome pandemic pathophysiology pathway Patient PD-L1 potential therapeutic targets predict Predictive predictive models Predictive value predictor radiological receptor RNA RNA seq ROC ROC analysis serum severe cases severity the disease transcriptomics tumor necrosis urea validation cohort variant [DOI] 10.3389/fimmu.2022.865845 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13기도 세포의 SARS-CoV-2 감염은 IL-13에 의해 영향을 받는 두 가지 확산 메커니즘인 강력한 바이러스 및 세포 방출을 유발합니다Article Published on 2022-04-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected airway airways Allergic asthma Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Asthma asthmatic cause caused Cell Cell culture cell cultures cell tropism cells ciliated cell ciliated cells coronavirus COVID-19 COVID-19 severity down-regulated gene down-regulated genes electron microscopy enzyme epithelial epithelial cells examined expression gene expression analyses Gene Expression Omnibus Genes glycoprotein HAE high risk host–virus interaction human airway human airway epithelial human airway epithelial cells IL-13 IL-13 cytokine immunohistochemistry In situ hybridization infected cells Infection interferon interleukin interleukin-13 Intracellular involved keratan sulfate Lung disease mechanism Messenger RNA Microscopy MUC5AC mucin Mucus number of infected primary human airway reduced removal Replication RNA RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shedding shielding significantly Spread sulfate susceptibility Transmission Transport TRAP treated up-regulated viral egress viral entry Viral load Viral reservoir viral spread viral titers virions viruses were infected [DOI] 10.1073/pnas.2119680119 PMC 바로가기 [Article Type] Article
Inflammation and Mortality in COVID-19 Hospitalized Patients With and Without Type 2 Diabetes제2형 당뇨병이 있거나 없는 COVID-19 입원 환자의 염증 및 사망률Article Published on 2022-04-192022-09-11 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] Coronavirus, COVID19(2023년), SARS, 바이오마커, [키워드] 95% CI adjusted odds ratio association benefit Case-control center chemokine chemokines Columbia University Columbia University Irving Medical Center components conducted COVID-19 COVID-19 mortality COVID-19 patient CXCL10 CXCL8 cytokine Cytokine storm Cytokines death determine diabete diabetes elevated hospitalized patient hospitalized patients Hypothesis IFN-γ IL-1β IL-6 IL-6 inhibitor IL-8 immunoassays Inflammation inflammatory chemokine inflammatory chemokines Inflammatory cytokine Inflammatory marker inflammatory markers innate immune pathway Innate immunity interferon interleukin Intervention IP10 log-transformed logistic regression models marker Mortality Necrosis patients with diabetes positive Principal component principal components Protein quantified Regression model SARS-CoV-2 serum Serum level Significant significantly similarities similarity stratified TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α Type type 2 diabete type 2 diabetes were used with COVID-19 [DOI] 10.1210/clinem/dgac003 PMC 바로가기 [Article Type] Article
Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor인터페론 자극 유전자에 대한 유도성 CRISPR 활성화 스크린은 OAS1을 SARS-CoV-2 제한 인자로 식별합니다Article Published on 2022-04-142022-09-11 Journal: PLoS Pathogens [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Activation activities Antiviral Antiviral effect approach catalytic activity cDNA cell line complementary confounding effect CRISPR described exhibited experiments expression Factors function Genetic identify interferon interferon-stimulated gene interferon-stimulated genes interferons ISG ISGs mechanism OAS1 platform required respond restrict restriction factor Result SARS-CoV-2 specificity subset [DOI] 10.1371/journal.ppat.1010464 PMC 바로가기 [Article Type] Article