Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2COVID-19 환자의 비인두 샘플 전사체 및 다른 SARS-CoV-2 감염 모델과의 비교 분석은 SARS-CoV-2에 대한 이질적인 숙주 반응을 보여줍니다Comparative Study Published on 2021-01-072022-09-10 Journal: Journal of Translational Medicine [Category] 변종, 유전자 메커니즘, [키워드] ACE2 Analysis Antigen presentation Apoptosis Atf3 CCL2 CCL4 CCR1 COVID-19 COVID-19 patient CXCL2 cytokine cytokine signaling disparate DPP4 effective enrichment analysis exhibited expressed expression feature Functional enrichment analyses GATA6 Genome variations genomic HDAC2 Host host response Host transcriptional response host transcriptome hypoxia IFN IL1A IL6 immune immune response immune system incorporation induction of apoptosis Innate immunity integrin Integrins interferon Invasion isolates ITGA2B ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAE ITGAV ITGB3 ITGB7 lung Lung injury Lungs Missense mutation nasopharyngeal cells nasopharyngeal sample Nasopharyngeal samples NFAT non-structural protein overexpression Pathogenesis patients progression protease reported response Result SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection TCF12 transcription factor transcription factors Transcriptome upregulation Viral viral pathogenesis Viral protein Viral proteins virus [DOI] 10.1186/s12967-020-02695-0 PMC 바로가기 [Article Type] Comparative Study
Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthmaResearch Published on 2021-01-072022-10-28 Journal: Respiratory Research [Category] COVID-19, [키워드] ACE2 angiotensin Asthma biopsies biopsy Blood body mass index clinical parameter Clusters Cohort Corticosteroid COVID-19 disease enzyme European examined expressed expression expression level functions furin FURIN gene Gender Gene Expression greater host cells inflammasome activation Inflammation inflammatory cells Invasion Level lung male Microarray molecular molecular phenotype morbidity and mortality mRNA expression multivariate analyses neutrophil neutrophilic Neutrophils outcome oxidative phosphorylation Phenotypes protease Proteases Result risk SARS-COV-2 infection serine 2 Severe asthma severity significantly significantly higher significantly increased sputum TMPRSS2 TMPRSS2 level transmembrane Type [DOI] 10.1186/s12931-020-01605-8 PMC 바로가기 [Article Type] Research
DCs-based therapies: potential strategies in severe SARS-CoV-2 infectionDC 기반 치료법: 심각한 SARS-CoV-2 감염에 대한 잠재적 전략Review Published on 2021-01-012022-09-10 Journal: International Journal of Medical Sciences [Category] MERS, 임상, [키워드] acute respiratory syndrome coronavirus Basis caused Cell Characteristics Combination coronavirus coronavirus 2 Coronavirus infection Coronavirus infections defend dendritic cell dendritic cells dendritic cells (DCs) vaccine described effort focus function Host immune system immune system response Immunotherapy Infection Invasion mechanism Pneumonia respiratory SARS-CoV-2 SARS-COV-2 infection sentinel severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection severe SARS severe SARS-CoV-2 Therapeutic approach therapeutic vaccine therapy Treatment Vaccine virus virus infection [DOI] 10.7150/ijms.47706 PMC 바로가기 [Article Type] Review
Is the oral cavity a reservoir for prolonged SARS-CoV-2 shedding?구강은 장기간 SARS-CoV-2 배출을 위한 저장소입니까?Case Reports Published on 2021-01-012022-09-11 Journal: Medical Hypotheses [Category] MERS, SARS, 진단, 치료기술, [키워드] Analysis Antiviral effect antiviral effects Asymptomatic COVID-19 can not Care Case fatality rate cells clinically Contagiosity COVID-19 Critical dentistry detect Efficacy effort Fatality rate Health Health care Hypothesis immune system activity innate immune Invasion knowledge limitation Limited mechanism modulate molecular myriad observation oral oral cavity oral tissues pathogenic viruses pathologic Patient patients persistence positive provide Research risk SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 RNA SARS-CoV-2 transmission specimen throat swab tissue to define Transmission virus [DOI] 10.1016/j.mehy.2020.110419 PMC 바로가기 [Article Type] Case Reports
Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 CRISPR-Cas13a의 신속한 설계 및 개발Research Paper Published on 2021-01-012022-09-10 Journal: Theranostics [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 Antiviral approach AT2 bioinformatics candidate caused cells cleavage coronavirus Coronaviruses COVID-19 CRISPR CRISPR-Cas13a disease effective Efficiency Epidemic HepG2 Host identify in-silico Invasion molecular docking offer provide Rapid respiratory Respiratory Coronavirus Result RNA RNA-editing robust SARS-CoV-2 SARS-CoV-2 spike protein selected sequence Sequence alignment Spike protein Structure tested the spike protein therapeutic therapeutic target Viral protein Viral proteins [DOI] 10.7150/thno.51479 PMC 바로가기 [Article Type] Research Paper
Road Map to Understanding SARS-CoV-2 Clinico-Immunopathology and COVID-19 Disease SeverityReview Published on 2020-12-232022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] adaptive affecting Arm biochemical clinical-immunological features clinician COVID-19 Disease progression disease severity early diagnosis Elderly patient feature Health host immunity host’s immune system immunological infected patient infected with SARS-CoV-2 Inflammation Invasion major organ management Map Mild molecular Novel coronavirus pandemic patients road SARS-CoV-2 Spread the cytokine storm the disease the patient those with comorbidities turn understanding undetectable upper respiratory tract virus WHO World Health Organization Wuhan, China [DOI] 10.3390/pathogens10010005 PMC 바로가기 [Article Type] Review
Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and InfectionCell and Developmental Biology Published on 2020-12-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Activation activity administration alarm arteriogenesis Bacteria Blood cells bypasses cardiovascular disease circulating cofactor condition Contact COVID-19 DAMP DAMPs danger-associated molecular patterns defense process demonstrated dissemination docking edema effective endothelial endothelial cells Endothelium ENhance Extracellular extracellular nucleic acids growth help histone host cell immune defense implicated in vitro in vivo include Inflammation Inflammatory inflammatory macrophages inflammatory vascular diseases influence initiate innate immune response Interaction intracellular material Invasion investigated Ischemia leukocyte limit microbial microbial infection microRNA molecular Non-coding RNAs non-toxic nucleic acid pro-thrombotic promote provide provoke Reactions recruitment regimen RNA RNase1 Safe signal subsequent therapeutic thrombosis tissue damage Vascular Vascular injury VEGF vessel vessel wall viral infection viral particle virus virus infection while wound healing [DOI] 10.3389/fcell.2020.619221 PMC 바로가기 [Article Type] Cell and Developmental Biology
High-throughput genotyping assays for identification of glycophorin B deletion variants in population studies인구 연구에서 글리코포린 B 결실 변이를 식별하기 위한 고처리량 유전자형 분석법Article Published on 2020-12-162024-08-26 Journal: Experimental Biology and Medicine [Category] 말라리아, [키워드] Glycophorins GYPB deletion Invasion malaria Plasmodium red blood cell [DOI] 10.1177/1535370220968545 PMC 바로가기
Contributory role of SARS-CoV-2 genomic variations and life expectancy in COVID-19 transmission and low fatality rate in AfricaResearch Published on 2020-12-092022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] accumulation Africa African age Analysis analyzed average Characteristics claimed contributed coronavirus country COVID-19 COVID-19 transmission D614G database death drug resistance economic devastation Epidemiology Factor Factors fatality Fatality rate Genomic variability genomic variation GISAID Health health care systems highest Host incidence infected patient initiative Invasion lockdown Low fatality Mutation mutational hotspot mutations novel coronavirus disease nucleocapsid Older outbreak pandemic predicted Prevalence prevalence of COVID-19 public health recurrent mutation Region Regulatory Result RNA-dependent RNA polymerase SARS-CoV-2 selective sequence Sequencing spike glycoprotein Strains the disease the SARS-CoV-2 Transmissibility viral sequence virulent virus [DOI] 10.1186/s43042-020-00116-x PMC 바로가기 [Article Type] Research
Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortalityCOVID-19 환자의 심각한 급성 신장 손상은 병원 내 사망률과 관련이 있습니다.Research Article Published on 2020-12-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval Acute kidney injury administration affected age AKI Analysis complications of COVID-19 COVID-19 COVID-19 patient creatinine creatinine kinase criteria cumulative cumulative survival rate defined elevated evaluate Final Follow-up hazard hazard ratio hospital Hospitalized ICU identify Improving In-hospital death in-hospital mortality incidence independent risk factor independent risk factors intensive care intensive care unit Invasion Kaplan-Meier curve Kaplan-Meier curves KDIGO Kidney disease kidneys lowest lung Lungs lymphocyte mechanical ventilator multivariable analysis Neutrophil-to-lymphocyte ratio old age other organs outcomes Patient patients patients with AKI patients with COVID-19 patients without AKI rates of admission renal Retrospective study serum creatinine significantly higher stage 2 survival rate target the patient [DOI] 10.1371/journal.pone.0243528 PMC 바로가기 [Article Type] Research Article