Could a Lower Toll-like Receptor (TLR) and NF-κB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron?스파이크 단백질의 전하 분포 변화로 인한 낮은 TLR(Toll-like Receptor) 및 NF-κB 활성화가 오미크론의 낮은 병원성 원인이 될 수 있습니까?Review Published on 2022-05-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] Activation airway B.1.1.529 cellular changed charge cleavage clinics COVID-19 cytokine Cytokine storm Deletion deletions delta variant distribution Efficacy favor furin furin cleavage site FURIN expression Hypothesis immune immune cells immunization Innate immune cells Lower Lungs monoclonal antibody Multiple Mutation N-terminal domain Neutralizing antibodies neutralizing antibody NF-kappaB NF-κB NF-κB activation NTD omicron Omicron variant organs other variants pathogenicity predicted RBD reason for receptor Receptor binding domain replacing Replication resulting S1/S2 S1/S2 furin cleavage site SARS-CoV-2 significantly lower Spike protein Substitution syncytium formation the Spike the spike protein therapeutic TLR TLRs TMPRSS2 Toll-like receptor Toll-like receptor (TLR) Toll-like receptors upper airway variant viral replication wild-type virus [DOI] 10.3390/ijms23115966 PMC 바로가기 [Article Type] Review
Well-being app to support young people during the COVID-19 pandemic: randomised controlled trialRandomized Controlled Trial Published on 2022-05-192022-10-05 Journal: BMJ Open [Category] 임상, [키워드] Adolescent analysed Anxiety application baseline Care changes in clinical clinically Compassion controls coping skills COVID-19 COVID-19 pandemic Depression Developed effective Efficacy emotional Endpoint engage evaluate evaluated form group Health help index indicated individual Interaction intervention group linear mixed model media Mental mental health mHealth Mobile mobile apps New outcome outcomes pandemic participant Perceived Stress Scale physical Prospective Psychological Quality randomised controlled trial recruited registry remained Resilience scale secondary self self-compassion Seven significantly higher significantly lower Sleep statistically significant statistically significant difference Stress Support the WHO Usability Well-being young adult [DOI] 10.1136/bmjopen-2021-058144 PMC 바로가기 [Article Type] Randomized Controlled Trial
N6-Acetyl-L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese PatientsN6-아세틸-L-라이신 및 p-크레졸이 비만 환자에서 코로나19 발병의 주요 대사산물로 작용Article Published on 2022-05-192022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetyl acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting anti-inflammatory function Antiviral cardiovascular disease caused changes in clinical outcomes complications coronavirus COVID-19 COVID-19 cohort COVID-19 negative COVID-19 obese patient COVID-19 obese patients cresol Data analysis exhibiting explain Glucose Health help highlight identify improve clinical outcomes in viral indicated marker mass spectrometry metabolic pathway metabolic pathways Metabolic regulation metabolic syndrome metabolite metabolites metabolomics obese obese patients obesity p-cresol patients plasma metabolome positive Regulation risk factor SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe complications signature significantly significantly higher significantly lower steroid susceptibility syndrome UHPLC ultra-high-performance liquid chromatography-mass spectrometry. viral entry viral infection with COVID-19 [DOI] 10.3389/fimmu.2022.827603 PMC 바로가기 [Article Type] Article
Outbreak investigation of airborne transmission of Omicron (B.1.1.529) – SARS-CoV-2 variant of concern in a restaurant: Implication for enhancement of indoor air dilution오미크론(B.1.1.529) 공중전파 발생 조사 - 식당에서 우려되는 SARS-CoV-2 변종: 실내 공기 희석도 향상에 대한 시사점Article Published on 2022-05-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 변종, [키워드] Air purifier Airborne transmission attack rate B.1.1.529 COVID-19 COVID-19 outbreak demonstrated Dilution distribution enhancement epidemiological explain exposure time increasingly index index case Indoor air dilution investigated mandatory median occurred omicron Omicron variant outbreak Outbreak investigation phylogenetic analyses phylogenetically restaurant risk SARS-CoV-2 transmission SARS-CoV-2 variant secondary attack rate secondary case secondary cases significantly lower smoke Transmission transmission of SARS-CoV-2 variant Ventilation [DOI] 10.1016/j.jhazmat.2022.128504 PMC 바로가기 [Article Type] Article
Omicron SARS-CoV-2 variant of concern: A review on its transmissibility, immune evasion, reinfection, and severity우려되는 Omicron SARS-CoV-2 변종: 전염성, 면역 회피, 재감염 및 중증도에 대한 검토Review Published on 2022-05-132022-09-11 Journal: Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Admission article booster caused country COVID-19 infections Delta dominant effective evade faster Fatality rate global healthcare Google Scholar Hospital stay Hospitalization immune immune evasion Immunity incidence Infection infections intensive care intensive care unit admission less mechanical ventilator median omicron other variant other variants Reinfection reported SARS-CoV-2 variant severe COVID-19 infections severity significantly significantly lower Spread Transmissibility vaccination Vaccine variant variants was performed [DOI] 10.1097/MD.0000000000029165 PMC 바로가기 [Article Type] Review
Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients’ Outcomes-A Single-Center Experience and a Brief Review of the LiteratureCOVID-19 환자의 낮은 혈청 비타민 D는 염증 마커 및 환자의 결과와 관련이 없습니다-단일 센터 경험 및 문헌에 대한 간략한 검토Review Published on 2022-05-102022-09-11 Journal: Nutrients [Category] MERS, 바이오마커, [키워드] Admission age association C reactive protein Comorbidities Comorbidity correlation COVID-19 CRP disease disease severity evaluate except for experience ferritin fibrinogen form forms groups highest hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patients Inflammation Inflammatory Inflammatory biomarker inflammatory biomarkers IQR Laboratory laboratory procedures leukocytes literature median Mild Mild disease moderate Patient Peripheral blood peripheral blood leukocytes Prospective Study review Serum level serum levels severe COVID-19 significantly significantly higher significantly lower stratified subject Vitamin D vitamin D level vitamin D levels vitamin D serum Vitamin D status was collected was performed were assessed [DOI] 10.3390/nu14101998 PMC 바로가기 [Article Type] Review
Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity장기 allo-HSCT 생존자에서 백신 접종 후 SARS-CoV-2 T-세포 반응의 결핍은 체액성 면역 감소로 해석됩니다Article Published on 2022-05-102022-09-11 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Amino acid analyzed anti-RBD BNT162b2 Control coronavirus COVID-19 COVID-19 vaccines death deficiency detectable determine disease Ex vivo Fisher Fisher's exact test healthy control hematological Hematopoietic stem cell HSCT Humoral immunity humoral responses IgG immunogenicity Immunoglobulin Immunoglobulin G interferon interferon-γ lack median mRNA mRNA-1273 Odds ratio of BNT162b2 overlap Patient peptide peptides rate of seroconversion RBD reactivity Receptor binding domain recipient recipients reflected respiratory risk S1 IgG SARS-CoV-2 second vaccination Seroconversion seronegative serum severe acute respiratory syndrome Coronavirus severe disease significantly lower stem cell Stem cell transplantation stimulated substandard survivor T-cell T-cell immunity T-cell Response T-cell responses translate transplantation vaccination Vaccinations vaccine dose Whole blood [DOI] 10.1182/bloodadvances.2021006937 PMC 바로가기 [Article Type] Article
Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy Research Published on 2022-05-102022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI Admission adverse outcome affecting appear Cohort COVID-19 COVID-19 mRNA Vaccination COVID-19 vaccination COVID-19 vaccine death Effectiveness evaluated Evidence gestation higher risk intensive care Meta-analysis mRNA vaccination mRNA vaccines Neonatal outcome placental Pregnancy pregnant reduction in risk RT-PCR Safe Safety SARS-COV-2 infection second dose significantly lower Stillbirth vaccination Z-score [DOI] 10.1038/s41467-022-30052-w [Article Type] Research
RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19RAGE는 삽관되지 않은 COVID-19 입원 환자에서 잠재적인 병리학적 및 예후적 가치가 있습니다.Clinical Trial Published on 2022-05-092022-09-11 Journal: JCI Insight [Category] MERS, 바이오마커, 임상, 진단, 치료법, [키워드] adjusted age Antibody Response Antigen association bamlanivimab baseline Biomarker Biomarkers BMI clinical Clinical outcome clinical outcomes Clinical practice clinical trial Concentration correlated correlation Corticosteroid corticosteroid treatment COVID-19 Cox regression CRP Cytokines diabetes Diabetes Mellitus enrolled Factor highest Hospitalized hospitalized patient hospitalized patients IL-6 Illness severity Indicator likelihood mechanically ventilated nucleocapsid antigen oxygen participant Participants patients with COVID-19 plasma positive Prognostic value Pulmonology quartile RAGE rate ratio receptor renal impairment risk of death Sex significantly lower Spearman supplemental oxygen sustained systemic inflammation tested Trial Viral viral burden Viral load was measured was used were used with COVID-19 [DOI] 10.1172/jci.insight.157499 PMC 바로가기 [Article Type] Clinical Trial
Real-world clinical outcomes of treatment with casirivimab-imdevimab among patients with mild-to-moderate coronavirus disease 2019 during the Delta variant pandemic델타 변이형 대유행 기간 동안 경증에서 중등도의 코로나바이러스 질환 환자를 대상으로 한 카시리비맙-임데비맙 치료의 실제 임상 결과Article Published on 2022-05-092022-09-11 Journal: International Journal of Medical Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission body temperature Casirivimab casirivimab-imdevimab cigarette smoking clinical Clinical deterioration Clinical outcome contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Delta delta variant demonstrated Deterioration dyslipidemia Effectiveness Efficacy enrolled evaluated Fukushima greater hospital Hospitalization hypertension Imdevimab independent Japan Logistic regression analysis Mild-to-moderate monoclonal antibody monoclonal antibody therapy multivariate multivariate logistic regression analysis Neutralizing obesity Odds ratio Older pandemic Patient Propensity score real-world effectiveness. receiving reduce respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus significantly lower smoking therapy Treatment [DOI] 10.7150/ijms.71132 PMC 바로가기 [Article Type] Article