Safety, efficacy, and pharmacokinetics of pradefovir for the treatment of chronic hepatitis B infectionClinical Trial Published on 2020-02-012023-06-13 Journal: Antiviral Research [Category] B형 간염, [키워드] clinical trial pharmacokinetics prodrug Safety Viral hepatitis [DOI] 10.1016/j.antiviral.2019.104693 [Article Type] Clinical Trial
Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trialUpdate Published on 2020-01-032022-10-29 Journal: Trials [Category] Coronavirus, MERS, [키워드] Antiviral clinical trial Combination combination therapy coronavirus double-blind Efficacy hospitalized patient intention-to-treat principle Interferon-β1b laboratory-confirmed Lopinavir/ritonavir MERS MERS-CoV Middle East Mortality multicenter Placebo placebo-controlled primary analysis Primary outcome protocol provided Randomized controlled trial standard supportive care Statistical analysis plan syndrome Treatment Trial [DOI] 10.1186/s13063-019-3846-x PMC 바로가기 [Article Type] Update
Effective Anti-SARS-CoV-2 RNA Dependent RNA Polymerase Drugs Based on Docking Methods: The Case of Milbemycin, Ivermectin, and Baloxavir MarboxilShort Communication Published on 2020-01-012022-10-28 Journal: Avicenna Journal of Medical Biotechnology [Category] COVID-19, [키워드] Antiviral agents baloxavir baloxavir marboxil binding activity clinical trial COVID-19 Dependent docking drug drugs effective global pandemic high affinity highest binding affinity inhibitor Ivermectin Laboratory Milbemycin new virus RdRP respiratory RNA SARS-CoV-2 Tadalafil the disease the SARS-CoV-2 Treatment Vaccine Viral RNA PMC 바로가기 [Article Type] Short Communication
Dementia Care in the Time of COVID-19 PandemicComment Published on 2020-01-012023-07-05 Journal: Journal of Alzheimer's disease : JAD [Category] SARS, [키워드] access Alzheimer’s disease Caregivers clinical trial coronavirus COVID-19 Dementia Health care pandemic telehealth Telemedicine [DOI] 10.3233/JAD-200461 [Article Type] Comment
Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19중등도의 COVID-19가 있는 고령 환자에서 인간화 항-CD6 단클론항체(이톨리주맙)의 사용Clinical Trial Published on 2020-01-012022-09-12 Journal: Gerontology [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome age antibody Antiviral baseline caused circulating Clinical outcome clinical trial clinically Combination Comorbidities Complication Concentration control group control subject coronavirus coronavirus disease Course COVID-19 COVID-19 disease COVID-19 patient Cuba Cytokine release syndrome discharged dose elderly first dose humanized IL-6 ill patient immunomodulatory drugs immunomodulatory therapy individual intensive care itolizumab Local Medical conditions monoclonal antibody Mortality multiple comorbidity outbreak Pathologies Patient patients with COVID-19 polymerase chain positive receive reduce reduced remained reported reverse transcription risk of death SARS-CoV-2 SARS-COV-2 infection severity susceptibility susceptible tested the disease therapeutic took place Transmission treated Treatment Villa was selected worsening [DOI] 10.1159/000512210 PMC 바로가기 [Article Type] Clinical Trial
Insights into current clinical research on the immunogenicity of live attenuated influenza vaccinesReview Published on 2020-01-012023-06-23 Journal: Expert review of vaccines [Category] 신종인플루엔자, [키워드] antibody immune response cell-mediated immune response clinical trial Correlate of protection immunogenicity live attenuated influenza vaccine [DOI] 10.1080/14760584.2020.1711056 [Article Type] Review
Approaches for the Treatment of SARS-CoV-2 Infection: A Pharmacologic View and Literature ReviewReview Article Published on 2020-01-012022-10-30 Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome (ARDS) approach ARDS caused China clinical manifestations clinical trial coronavirus coronavirus 2 Coronavirus disease 2019 COVID-19 COVID-19 disease disease drugs targeting effective effective drug effort elements host cell identify knowledge literature medication Mild moderate new virus offered outcomes pandemic Pharmacologic potential therapy public health Quickly respiratory review SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severity Spread Stage suggested syndrome the disease therapy Treatment View virus [DOI] 10.22037/ijpr.2020.113821.14506 PMC 바로가기 [Article Type] Review Article
COVID-19-associated ARDS treated with DEXamethasone (CoDEX): study design and rationale for a randomized trialDEXamethasone(CoDEX)으로 치료된 COVID-19 관련 ARDS: 무작위 시험에 대한 연구 설계 및 근거Original Article Published on 2020-01-012022-08-13 Journal: Revista Brasileira de Terapia Intensiva [Category] 임상, [키워드] 350 patient 350 patients 48 hour 48 hours 6-level ordinal scale acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Adrenal cortex hormones Adult patients all-cause mortality rate all-cause mortality rates assessment Berlin criteria caused clinical status clinical trial Control control group Controlled trial coronavirus coronavirus disease Coronavirus disease 2019 coronavirus disease 2019 - COVID-19 Corticosteroid Corticosteroides Corticosteroids COVID-19 COVID-19-associated ARDS Cuidados críticos days alive defined develop Dexametasona Dexamethasone dexamethasone 10mg IV dexamethasone 20mg intravenous early-onset Effectiveness Eligible patients evaluate evaluated failure followed by group hospitalized patient hospitalized patients Infection intensive care intervention group intravenous Invasive mechanical ventilation less mechanical ventilation mechanical ventilation duration moderate mortality rates multicenter Non-COVID-19 non-COVID-19 acute respiratory distress syndrome objective occur once daily Open-label Ordinal Scale outcome pandemic Patient patients with moderate Pneumonia Pragmatic Primary outcome randomization Randomized randomized trial Randomly receive respiratory respiratory compromise respiratory distress Respiratory distress syndrome Respiratory distress syndrome, adult Síndrome do desconforto respiratório do adulto SARS-CoV-2 SARS-COV-2 infection score secondary Secondary outcomes severe acute respiratory syndrome Coronavirus Spread standard treatment stratified Study design syndrome treated Trial unit discharge ventilator-free day Ventilator-free days Viral Viral pneumonia [DOI] 10.5935/0103-507X.20200063 PMC 바로가기 [Article Type] Original Article
Use of Intravenous Immunoglobulin (Prevagen or Octagam) for the Treatment of COVID-19: Retrospective Case SeriesCOVID-19 치료를 위한 정맥 면역글로불린(Prevagen 또는 Octagam)의 사용: 후향적 사례 시리즈Observational Study Published on 2020-01-012022-09-11 Journal: Respiration [Category] MERS, 임상, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome administration Admission ARDS attenuate caused chronic Clinical course clinical courses clinical trial Comorbidity coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 infection COVID-19 patient D-dimer demonstrated disease distress dose dose administration doses elevated evaluated hospital discharge Hospital stay ICU Illness severity Immunoglobulin immunomodulators IMPROVE Inflammatory response Inflammatory responses Intravenous immunoglobulin IVIG Mann-Whitney U test mechanical ventilation median median age median time men moderate moderate to severe occurred Patient patients with moderate Physiology ranged reduce reduce mortality regimen resources respiratory distress Respiratory distress syndrome score Sery Severe COVID-19 Infection significantly shorter Stage survived syndrome thrombotic thrombotic event Thrombotic events Treatment utilization Ventilation women [DOI] 10.1159/000511376 PMC 바로가기 [Article Type] Observational Study
Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in humanarticle Published on 2019-12-312024-09-01 Journal: Human vaccines & immunotherapeutics [Category] 세균성이질, [키워드] Bioconjugate carbohydrate antigen clinical trial glycan glycoconjugate lipopolysaccharide O-acetylation oligosaccharide Shigella Vaccine [Article Type] article