Stress – Page 246 – Communicable Diseases Research

The Drosophila MAPK p38c Regulates Oxidative Stress and Lipid Homeostasis in the Intestine

Drosophila MAPK p38c는 장의 산화 스트레스와 지질 항상성을 조절합니다

Research Article

Published on 2014-09-252022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

PRO40 Is a Scaffold Protein of the Cell Wall Integrity Pathway, Linking the MAP Kinase Module to the Upstream Activator Protein Kinase C

PRO40은 MAP 키나제 모듈을 업스트림 활성제 단백질 키나제 C에 연결하는 세포벽 무결성 경로의 스캐폴드 단백질입니다.

Research Article

Published on 2014-09-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activator adapter adapters Affinity purification Alzheimer's disease approach ascomycete asexual development bind Cancer Cell cell differentiation Cell fusion cell wall characterized combating conserved Control deletion mutant deletion mutants determinant developmental developmental processe developmental processes disease domain ENCODE environmental cue environmental cues eukaryote eukaryotes eukaryotic Evidence experiment Extensive filamentous fungi fruiting bodies fungal fungi fungus Genetic growth homolog implicated integrity Interaction interaction partner involved kinase MAPK mass spectrometry mitogen mitogen-activated protein kinase module molecular MOST mutant mutated N-terminal Pathogenesis pathogenicity pathway Pathways Phosphorylation polar Protein protein kinase protein kinase C Regulation required scaffold protein Signal transduction Signaling Sordaria macrospora Stress stress response symbiosis the cell upstream vegetative growth wall yeast
[DOI] 10.1371/journal.pgen.1004582 PMC 바로가기 [Article Type] Research Article

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

Article

Published on 2014-08-022022-11-01
Journal: Virus research [Category] Coronavirus,

[키워드] activated activated T cell activating Activation acute respiratory distress Adaptive immune response addressed Affect animal model antagonist Apoptosis ARDS attenuate B cell binding cause cellular cellular pathway coronavirus CoV CoV genome CoV infection CoV protein cytokine death deleted deletion mutant described disease disease severity domain driver E protein edema elicit elicited envelope gene envelope protein exacerbated Host Host immune response humans IFN immune response immunopathological induce Infection inflammasome activation Inflammation Inflammatory response influence inhibiting innate immune responses innate immune system Innate immunity Interaction interferon interferon regulatory factor involved lung parenchyma manuscript MERS-CoV MHV mice Modification motif NF-κB NF-κB pathway nuclear Pathogenesis pathogenic pathogenicity pathway patients priming proinflammatory Proinflammatory cytokine promote proportion Protein Regulation Replication responses responsible SARS-CoV SARS-CoV E sequence shown Signaling signaling pathway Stress subgenomic mRNA synthesis syndrome TGEV transcription factor transmembrane transmembrane domain triggered vaccine candidates viral infections Viral protein virulence virulence gene virus virus infection
[DOI] 10.1016/j.virusres.2014.07.024 PMC 바로가기 [Article Type] Article

An Essential Nonredundant Role for Mycobacterial DnaK in Native Protein Folding

천연 단백질 폴딩에서 마이코박테리아 DnaK의 필수 비중복 역할

Research Article

Published on 2014-07-242022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a minor absence accompanied accumulation aggregate antibiotic Bacterial pathogens bacterium Cell cell growth cells cellular chaperone chaperones characterized daughter cells Degradation denaturation Disruption domain E. coli Essential examined expand expression Factor foci genus growth heat Host Hsp70 identify include insoluble lack less life Loss membrane minor mycobacteria mycobacterial Mycobacterium Native organism paradigm Pathogens peptide peptides Prevent Protein protein folding Protein misfolding Proteins redundancy required role solubility stationary stationary phase Stress susceptibility synthases translation Trigger unique viability
[DOI] 10.1371/journal.pgen.1004516 PMC 바로가기 [Article Type] Research Article

Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation

Cryptococcus neoformans var.의 게놈 및 전사체 분석 grubii, 복잡한 RNA 발현 및 독성 약화로 이어지는 소진화를 밝혀냄

Research Article

Published on 2014-04-172022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a major addition alternative polyadenylation Analysis analyzed annotation attenuation automated C. neoforman CDS chromosomal coding coding DNA sequence coding DNA sequences Comparative analysis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans death Efficiency examination expressed gene expressed genes feature fungi Gene Expression Genes Genetic genetics Genome genome sequence genomic studies genomic study human pathogen identify Immunocompromised Immunocompromised patients in vitro culturing indicate intron introns involved isolate isolates Laboratory leading manual curation meningoencephalitis microevolution microevolutionary miscRNA miscRNAs molecular motif Mutation Non-coding RNAs occur opportunistic pathogen pathogen pathogenic performed phenotypic phenotypic and genome re-sequencing analysis polyadenylation site polyadenylation sites provide Region Regulation Replication representing responses responsible resulting RNA RNA-Seq-based analysis sequence sequenced sequences Sequencing serotype Spectrum strain Stress stress responses Transcription Transcriptome untranslated regions UTRs VAR variant variety virulence yeast
[DOI] 10.1371/journal.pgen.1004261 PMC 바로가기 [Article Type] Research Article

Nucleic Acid Aptamers Stabilize Proteins Against Different Types of Stress Conditions

핵산 압타머는 다양한 유형의 스트레스 조건에 대해 단백질을 안정화시킵니다.

journal-article

Published on 2014-01-012024-07-30
Journal: Pathogens [Category] 파상풍,

[키워드] adjuvant alumina aptamer Formulation oligonucleotides Proteins stability Stress tetanus toxoid
[DOI] 10.1002/jps.23785 [Article Type] journal-article

Integrative “Omics”-Approach Discovers Dynamic and Regulatory Features of Bacterial Stress Responses

통합 "Omics" 접근 방식으로 세균 스트레스 반응의 동적 및 조절 기능 발견

Research Article

Published on 2013-06-202022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] (transcriptome adaptation adaptive mechanism adaptive mechanisms addition alternative approach assigned Author Bacteria cellular stress responses change choice complex conditions determine different dynamic Effect elevated temperature event events example exhibited expression expression level expression pattern expressome Factor Factors feature found fraction Frequency Gene Genes Genome help in addition to include initiated integration maintain mass spectrometry Microarrays mRNA mRNA level mRNA levels mRNAs Occurrence open reading frames operon organism oxygen phototrophic polar polysome Population post-transcriptional level Protein Proteins proteome provided quantification quorum regulated Regulation Regulatory reported required response RNA-Seq RpoE singlet oxygen Stress stress condition stress conditions stress response stress responses survival transcriptional activation transcriptional level transcriptional regulator transcriptional regulators Transcriptome translation translational was used
[DOI] 10.1371/journal.pgen.1003576 PMC 바로가기 [Article Type] Research Article

RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio cholerae

RpoS는 Vibrio cholerae에서 치명적이지 않은 아미노글리코사이드 농도에 의한 SOS 유도에서 중심 역할을 합니다

Research Article

Published on 2013-04-112022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addressed Aminoglycoside Antibiotic resistance Antibiotics Author Bacteria Bacterial caused cellular mechanism cellular mechanisms CENTRAL Concentration connection conserved corollary different DNA DNA damage DNA damaging E. coli Escherichia coli flow cytometry found Frequency fusion gene transfer Genetic Genome genomic plasticity gram growth guanine horizontal gene Horizontal gene transfer increase in induce induction inhibit inhibitory concentration Klebsiella pneumoniae leads low dose Mutation mutations Other over-expression oxidative oxidative stress oxidative stress response oxidized oxygen paradigm pathogen Pathogens pathway Pathways physiological effect physiological effects physiological response pneumoniae Prevent promoter Protein reactive oxygen specy regulated related role RpoS shown SOS SOS response Stress stress conditions stress response Testing tobramycin transfer V. cholerae Vibrio cholerae
[DOI] 10.1371/journal.pgen.1003421 PMC 바로가기 [Article Type] Research Article

Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression

Research

Published on 2013-01-192022-10-28
Journal: Virology Journal [Category] Coronavirus,

Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin

기아는 SOS 반응과 함께 Fluoroquinolone Ofloxacin에 대한 높은 생물막 특정 내성을 매개합니다

Research Article

Published on 2013-01-032022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a minor age Amino acid amino acids antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial biofilm carbon carbon source Community Concentration Critical demonstrated dependent on Escherichia coli exhibited functional greater growth hallmark heterogeneity heterogeneous Hypothesis identify infections influence lead leucine Medical devices microenvironment minor molecular mechanism molecular mechanisms multicellular Mutagenesis mutant mutants ofloxacin organism physiological physiological state planktonic random response significantly SOS SOS response starvation Stress stress response subpopulation subpopulations Support systemic infections Tolerance transposon
[DOI] 10.1371/journal.pgen.1003144 PMC 바로가기 [Article Type] Research Article