Small-molecule polymerase inhibitor protects non-human primates from measles and reduces sheddingArticle Published on 2021-09-022022-10-04 Journal: Nature Communications [Category] 치료제, [키워드] alleviate antivirals characteristic Clinical sign contagious cough disease effective exacerbate Fever human host Immunosuppression Infection inhibitor lymphocyte measles virus non-human primate occur outbreak outcome pathogen Pathogens pathology polymerase Preclinical research Prevent Prophylactic Prophylaxis PROTECT Rash reduce reduced respiratory route Result Support Therapeutic treatment Vaccine viral infection virus [DOI] 10.1038/s41467-021-25497-4 PMC 바로가기 [Article Type] Article
Surveillance and care for confirmed and suspected patients with COVID-19 in general practice (CovidCare): study protocol for an observational trialStudy Protocol Published on 2021-09-022022-10-04 Journal: BMC Family Practice [Category] SARS, 임상, [키워드] Admission Analysis Anxiety Asymptomatic can be used Care Care tool clinical clinics Consequences contagious Course COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patient Critical disease Data analysis Diagnosis Effect eligible expected general practitioner Health high risk hospital hospitalisation include Infection initial management mortality rate outcome Outpatient sector Palliative care pandemic patients Pneumonia Predictive Primary outcome questionnaire regression models risk factor Risk factors SARS-COV-2 infection secondary Sickness study participation Study protocol supplementary material Support Surveillance Surveillance tool suspected patient Symptom Symptom diary Symptoms the disease Trial with COVID-19 [DOI] 10.1186/s12875-021-01515-8 PMC 바로가기 [Article Type] Study Protocol
Implementation of a COVID-19 cohort area resulted in no surface or air contamination in surrounding areas in one academic emergency departmentCOVID-19 코호트 지역의 구현으로 하나의 학술 응급실에서 주변 지역의 표면 또는 대기 오염이 발생하지 않았습니다.Article Published on 2021-09-012022-09-11 Journal: The American journal of emergency medicine [Category] SARS, 치료기술, [키워드] analyzed changed Cohort collected contagious Contamination COVID-19 COVID-19 cohort COVID-19 pandemic Department determine dissemination doffing donning E gene Effectiveness eight Emergency emergency department evaluate exit Face shield germicidal HCW Health care health care workers implementation individual Infection infection control measure minimal air N-95 Nurse Nurses Patient Patient care patients Personal protective equipment physician PPE PPE donning protocol protocols RT-PCR Sample SARS-CoV-2 Shield Spread the disease Viral sampling. zone [DOI] 10.1016/j.ajem.2021.04.082 PMC 바로가기 [Article Type] Article
Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like proteaseFDA 승인 항바이러스제, 항생제, 구충제, 항산화제 및 SARS-CoV-2 파파인 유사 프로테아제에 대한 세포 보호제의 용도 변경Article Published on 2021-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 진단, 치료제, [키워드] 6-mercaptopurine ACE acting Analysis Antacid Antibiotics anticancer drugs antimicrobial antioxidant antioxidants Antiviral antivirals approved drug benzimidazole binding affinities binding affinity binding energy binding pattern binding patterns blocker bypassing candesartan Cell contagious coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient COVID-19 patients Critical demonstrated docking score doripenem drug Drug discovery Drug repurposing drugs expected Famotidine fatal disease FDA-approved drugs followed by Guidance highest inhibitor list losartan MD simulations mercaptopurine molecular molecular dynamics moroxydine NAD+ oxiglutatione Papain Papain-like protease pharmacokinetic Phenformin PLPro primer protease Protective provided quercetin quercitrin receptor repurposing Ritonavir Safe SARS CoV SARS-CoV-2 sulfaguanidine surface area systemically Toxicity treat Vaccine development valsartan was used zanamivir [DOI] 10.1080/07391102.2020.1784291 PMC 바로가기 [Article Type] Article
Genomic surveillance to combat COVID-19: challenges and opportunitiesCOVID-19 퇴치를 위한 게놈 감시: 도전과 기회Review Published on 2021-09-012022-09-11 Journal: The Lancet. Microbe [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] contagious Containment COVID-19 pandemic COVID-19 vaccine detect effective Effective strategies effective strategy effort Evidence facilitate Genomic surveillance greater increasingly mitigate morbidity morbidity and mortality Next-generation sequencing Novel viruses offer outbreak Phylogenetic provide Safe SARS-CoV-2 variant SARS-CoV-2 variants Spread Vaccine variant variants virulent whole genome widespread [DOI] 10.1016/S2666-5247(21)00121-X PMC 바로가기 [Article Type] Review
The structural basis of accelerated host cell entry by SARS-CoV-2†SARS-CoV-2에 의한 가속화된 숙주 세포 진입의 구조적 기초†Article Published on 2021-09-012022-09-11 Journal: The Febs Journal [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] accelerate accelerated ACE-2 ACE2-RBD acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme Antiviral strategies antiviral strategy base C-terminal domain causative agent cell entry cellular entry cleavage site conserved Contact contagious contribute coronavirus Coronavirus disease 2019 COVID-19 disease domain effective entry receptor enzyme epithelial epithelium exhibit explain faster Features flat furin furin protease HCoVs high-affinity binding host cell human coronavirus hypothese Interaction leads Mutation N-terminal domain notable NTD other proteases pandemic pandemic coronavirus Proteases Protein protein-protein interaction RBD receptor Receptor-binding domain respiratory respiratory epithelia S protein S1 subunit SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sialic acid sialic acid-binding domain. Spike protein subunit the receptor-binding domain the S protein the S1 subunit the spike protein Tight binding turn Viral viral RBD viral S viral spike [DOI] 10.1111/febs.15651 PMC 바로가기 [Article Type] Article
Rapid and highly sensitive one-tube colorimetric RT-LAMP assay for visual detection of SARS-CoV-2 RNASARS-CoV-2 RNA의 시각적 검출을 위한 신속하고 고감도의 1관 비색 RT-LAMP 분석Article Published on 2021-09-012022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplifying bypassing caused clinics Community Concordance contagious contagious disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated diagnostic diagnostic test disease gold gold standard hospitals imperative isothermal amplification LAMP less limit of detection magnetic bead One-tube outbreak performed platform point-of-care test Rapid RNA RNA extraction RNA molecule RT-LAMP RT-qPCR test sample collection SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus specificity specimen Visual Visual readout. Volume [DOI] 10.1016/j.bios.2021.113330 PMC 바로가기 [Article Type] Article
Recovery of a patient with severe COVID-19 by acupuncture and Chinese herbal medicine adjuvant to standard care침술 및 중국 약초 보조제에 의한 심각한 코비드 -19 환자의 회복 표준 치료Case Reports Published on 2021-09-012022-08-31 Journal: Journal of integrative medicine [Category] MERS, 치료제, [키워드] Absorption accelerate acupuncture addition adjuvant adjuvants breath breathing function C-reactive protein Case report Chest computed tomography Chinese Chinese herbal medicine Combination Computed tomography contagious coronavirus disease Coronavirus disease 2019 COVID-19 CRP decrease dosage effective therapy female heart rate herbal medicine Integrative therapy lesion life-threatening Lung infection lymphocyte MLR monocyte neutrophil NLR Older oxygen Patient peripheral oxygen saturation rescue seeking Severe case Severe case. severe cases severe COVID-19 Shortness of breath significantly standard care the patient therapy treated was increased Wuhan Wuhan, China [DOI] 10.1016/j.joim.2021.06.001 PMC 바로가기 [Article Type] Case Reports
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte eliminationSARS-CoV-2 스파이크 단백질은 합포체 매개 림프구 제거를 지시합니다Article Published on 2021-09-012022-09-11 Journal: Cell Death and Differentiation [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-viral drug Anti-viral drugs cause cells cellular cellular structure contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy death expression identify induce inhibit lung tissue lung tissues lymphocyte Lymphocytes lymphocytopenia mechanism membrane fusion molecular motif patients polybasic prevalent respiratory S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike glycoprotein Structure structures Surface glycoprotein Syncytia syncytium target the SARS-CoV-2 therapy unique virus viruses [DOI] 10.1038/s41418-021-00782-3 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection Rate in Patients With Cancer and Health Care Workers in a Chemoradiotherapy Unit During the Pandemic: A Prospective Cohort in Mexico팬데믹 기간 동안 화학방사선치료실에서 암 환자 및 의료 종사자의 SARS-CoV-2 감염률: 멕시코의 예상 코호트Article Published on 2021-09-012022-09-11 Journal: JCO Global Oncology [Category] SARS, 치료기술, [키워드] anti-SARS-CoV-2 antibody anti-SARS-CoV-2 immunoglobulin antibody Asymptomatic asymptomatic infections baseline Biweekly Cancer cancer treatment center Chain Reaction chemoradiotherapy clinical questionnaire contagious COVID-19 COVID-19 pandemic COVID-19-related symptom COVID-19-related symptoms cumulative death detect determine diagnostic events Follow-up HCW Health care Health care worker health care workers Hospitalization IgG Immunoglobulin Immunoglobulin G incidence infection rate Informed consent Interaction likelihood ratio median Mexico City Nasopharyngeal swab nasopharyngeal swabs outcomes Participants Patient patient safety Patients with cancer performed polymerase chain polymerase chain reaction positive Positive predictive value positive RT-PCR Predictive value Prevent Prospective provided Quantitative Rate receive reverse transcriptase Reverse transcriptase polymerase chain reaction RT-qPCR SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection sensitivity Seroconversion seroconversion rate solid tumor solid tumors study period transcriptase Transmission Treatment tumors unit was performed were measured were recorded worker [DOI] 10.1200/GO.21.00207 PMC 바로가기 [Article Type] Article