dosage – Page 25 – Communicable Diseases Research

Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study

Research Article

Published on 2020-06-302022-10-29
Journal: World Journal of Emergency Surgery : WJES [Category] COVID-19, SARS,

Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol

Letter

Published on 2020-06-262022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 24 hour Administered airway allocation concealment Alpha ambient analysed aneurysms Anticoagulant treatment anticoagulation antiplatelet Arm arterial assigned Atrial fibrillation bleeding bleeding event block size Blood BMI Body Breastfeeding breath calculated Cancer clinical clinically Coagulopathy Concomitant conjunctival Continuous contributed Control control group Controlled trial corpus COVID-19 COVID19 criteria Critical D-dimer D-dimer level Day death defined detect diagnostic discharged disease severity dissemination dosage dose effective Efficacy and safety element enoxaparin Epistaxis EudraCT event events expected fibrinogen level gingival bleeding group Haemoglobin haemoptysis health-care hematemesis hematoma hemodynamic heparin High dose high risk history hospital discharge Hospital stay hospitalized patient hypersensitivity Hypothesis IL-6 Impaired impairing improvement IMV In-hospital indication initiated Inpatient INR internal Intervention intervention group Intra-articular intramuscular invasive Invasive mechanical ventilation involved Italian Italy laboratory parameter LMWH low dose low-molecular weight heparin macroscopic Major major bleeding management Mechanical mechanical ventilation medical intervention Medicine Modena NIV Non-invasive number objective occur Occurrence open label ophthalmic oral anticoagulant outcome oxygen paO2/fiO2 parallel group participant pathology Patient performed Pharyngeal swab plasma Platelet Pneumonia positive pregnancy test Presence pressure Primary outcome prophylactic dose prosthetic protocol random randomisation randomised randomised controlled randomised controlled trial randomization Rate receiving recorded recruited Rectal Bleeding reduce reduction in Registered renal function reported required respiratory risk risk of death Sample size SARS-CoV-2 secondary secure Severe COVID-19 pneumonia severe disease significantly Spontaneous standard oxygen therapy Stata status stratified stroke study drug Study protocol subcutaneously surgical susceptible symptomatic syndrome therapeutic dose therapy thrombocytopenia time transfusion Treatment unfractionated heparin unit Vascular venipuncture Venous Thromboembolism web-based system website weight Withdrawal worsening
[DOI] 10.1186/s13063-020-04475-z PMC 바로가기 [Article Type] Letter

Triiodothyronine for the treatment of critically ill patients with COVID-19 infection: A structured summary of a study protocol for a randomised controlled trial

COVID-19 감염이 있는 중환자 치료를 위한 Triiodothyronine: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2020-06-262022-08-13
Journal: Trials [Category] SARS, 임상,

[키워드] (therapeutic dose) 1:1 48 hour 48 hours Acute myocardial infarction addition Administered administration adopted allocation sequence Alpha Analysis blinded Blinding Caregivers clinical evidence collected comparator conserved copy Corticosteroid COVID-19 COVID-19 infected patient COVID-19 infection CRF criterion Critical Critical illness Critically ill Critically ill patient critically ill patients database defined detect Device diagnosed dissemination dosage dose double-blind drug Drug administration ECMO effective Efficacy and safety element enrolled Estimated EudraCT excluded extubation favorable effect female patient Final final analysis Follow-up followed by Germany Greece group hypoxia hypoxic condition hypoxic conditions ICU Identifier Ill illness immune system include increased mortality indicate information infusion initiation of treatment injection intensive care unit interim analysis investigator IWRS less Life expectancy maintenance dose MAPK mechanical respiratory mechanical ventilation multi-organ dysfunction number objective outcome participant Patient performed pharmacological treatment Placebo placebo controlled trial Pregnancy Primary outcome protocol Pulmonary infection randomisation randomised randomised controlled trial randomization Randomized recruited recruitment reveal Sample size Sepsis severe systemic disease signaling pathways solution Sponsor status study groups Study protocol subject Support systemic disease therapeutic therapeutic dose Thyroid thyroid hormone tissue trauma Treatment treatment allocation Trial Trial registration triiodothyronine unblinding university university hospital ventilatory support Version Viral viral infection Viral load website with COVID-19
[DOI] 10.1186/s13063-020-04474-0 PMC 바로가기 [Article Type] Letter

Letter to the editor: efficacy of different methods of combination regimen administrations including dexamethasone, intravenous immunoglobulin, and interferon-beta to treat critically ill COVID-19 patients: a structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-06-192022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 24 hours acute respiratory distress administration Admission age age and sex allergy ARDS Arm blinded Blood oxygen saturation can be used checked clinical coded Combination combination regimen Computed tomography conducted Contact Control control arm Corticosteroid Corticosteroids COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients Cytokine storm develop Dexamethasone dissemination dosage dose drug early administration education Efficacy element eligible excessive inflammatory response experimental group Frequency generate group help hepatitis B HIV positive hospital Hospitalization hospitalized patient Hypothesis Immunoglobulin IMPROVE increase in Inflammation information Interferon-beta Intervention intervention group Intravenous immunoglobulin intubation investigator Iran laboratory technician less lung lung damage management mortality rate MOST number Nurses objective outcome Parallel Arm participant Patient patients Patients management percentage positive RT-PCR Pregnancy protocol random random number generator randomised randomised controlled trial randomization Randomized controlled trial Randomly RCT receive reduce Registration reported researcher respiratory rate Sample size severe COVID-19 Side effects Standard standard treatment statistical statistician study drug study group Study protocol subject supportive care syndrome the cytokine storm the WHO treat Treatment Trial website WHO guideline
[DOI] 10.1186/s13063-020-04499-5 PMC 바로가기 [Article Type] Letter

From COVID-19 research to vaccine application: why might it take 17 months not 17 years and what are the wider lessons?

Commentary

Published on 2020-06-082022-10-31
Journal: Health Research Policy and Systems [Category] COVID-19, SARS,

Adding Colchicine to the Antiretroviral Medication – Lopinavir/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled Trial

Letter

Published on 2020-06-052022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 added Adding anti-inflammatory effect Antibiotics anticipated antioxidant antioxidants antiretroviral blinded both group CDC center change Clinical course Clinical improvement Colchicine component Consensus Controlled COVID-19 COVID-19 infection COVID-19 patients digoxin dissemination dosage double blind double-blind study element enrolled equation estimate Final GFR glomerular filtration rate group help Hospital stay hospitalized COVID-19 patients hypersensitivity hypoxic in both group infected with COVID-19 Inflammation inflammatory disorders Inpatient interleukin-8 intubation invasive Iran Kaletra kidney transplant recipients Lopinavir/ritonavir lung Lung CT MDA mechanism Minerals Nasopharyngeal swab National number objective outcome oxidative stress Oxygenation pandemic parallel group participant pathologic pathway Patient patients percentage Pneumonia positive Prospective protocol QTc randomised randomised controlled trial randomization Randomized Rate Ratio receive recruited recruitment reducing reduction Registered RT -PCR Sample size serum creatinine status Tehran time tomography Trace element treat treated Treatment two group two groups Vitamin website WHO guideline with COVID-19
[DOI] 10.1186/s13063-020-04455-3 PMC 바로가기 [Article Type] Letter

Effect of hydroxychloroquine on prevention of COVID-19 virus infection among healthcare professionals: a structured summary of a study protocol for a randomised controlled trial

Letter

Published on 2020-06-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 1:1 allocation analyzed anticipated approval blinded clinical symptom clinical trial Complete conducted Confirmed Contact Control control group COVID COVID-19 COVID-19 virus criteria dissemination dosage dose double-blind drug Dyspnea Effect element enzyme deficiency Epidemic Fever G6PD healthcare Healthcare professional healthcare professionals history hospital Hydroxychloroquine hypersensitivity independent Infection intervention group Iran Medical Sciences myalgia nausea number objective outcome participant Patient PCR pharmaceutical Pharmacy Placebo placebo-controlled trial polymerase chain reaction Prevent prevention prevention of COVID-19 Primary outcome protocol random randomised randomised controlled trial randomization randomization list Randomized recruitment researcher Sample size statistical status Study protocol Tablet Tehran treatment allocation treatment group Trial Trial registration underlying disease university virus virus infection website
[DOI] 10.1186/s13063-020-04439-3 PMC 바로가기 [Article Type] Letter

Chloroquine Dosing Recommendations for Pediatric COVID‐19 Supported by Modeling and Simulation

Brief Report

Published on 2020-05-212022-10-31
Journal: Clinical Pharmacology and Therapeutics [Category] COVID-19, MERS,

Model based approach for estimating the dosage regimen of indomethacin a potential antiviral treatment of patients infected with SARS CoV-2

SARS CoV-2에 감염된 환자의 잠재적인 항바이러스 치료 인도메타신의 투여 요법을 추정하기 위한 모델 기반 접근 방식

Original Paper

Published on 2020-05-202022-09-10
Journal: Journal of Pharmacokinetics and Pharmacodynamics [Category] MERS, SARS, 비임상,

Drug repurposing against COVID-19: focus on anticancer agents

Review

Published on 2020-05-122022-10-29
Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, MERS, SARS,