Fluoxetine hydrochloride loaded lipid polymer hybrid nanoparticles showed possible efficiency against SARS-CoV-2 infectionFluoxetine hydrochloride가 탑재된 지질 고분자 하이브리드 나노 입자는 SARS-CoV-2 감염에 대해 가능한 효율성을 보여주었습니다Article Published on 2021-09-252022-09-11 Journal: International journal of pharmaceutics [Category] SARS, 신약개발, [키워드] acute respiratory syndrome coronavirus Affect Anti-inflammatory anticoagulant effects antidepressant Antiviral approach approved drug binding energy cells cellular coronavirus COVID 19 COVID-19 COVID-19 pandemic disease drug Drug repurposing drugs Economy Efficiency encapsulation ENhance fibroblast Fluoxetine Fluoxetine hydrochloride global health Health Human hydrogen Hydrogen bond Interaction Lipid Lipid polymer hybrid lung management molecular docking molecular docking studies Molecular docking study optimization Paroxetine performed Polymer predict protease repurposing respiratory SARS-COV-2 infection SARS-CoV-2 main protease selective Serotonin serotonin reuptake inhibitor severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SSRIs. suggested therapeutic activity Treatment zeta potential [DOI] 10.1016/j.ijpharm.2021.121023 PMC 바로가기 [Article Type] Article
Repurposing nonnucleoside antivirals against SARS-CoV2 NSP12 (RNA dependent RNA polymerase): In silico-molecular insightSARS-CoV2 NSP12(RNA 의존성 RNA 폴리머라제)에 대한 비뉴클레오사이드 항바이러스제의 용도 변경: 인 실리코 분자 통찰력Article Published on 2021-09-242022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral target binding drug Drug discovery Drug repurposing effort enzyme FDA approved drug function functions inhibit inhibition Measures molecular molecular dynamic simulations new virus Nsp12 nucleoside pandemic Protein RdRP RdRp inhibitor Replication repurposing Research retained RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 screened Viral RNA Virtual screening virus while [DOI] 10.1016/j.bbrc.2021.07.050 PMC 바로가기 [Article Type] Article
A Drug Repurposing Approach for Antimalarials Interfering with SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD) and Human Angiotensin-Converting Enzyme 2 (ACE2)Article Published on 2021-09-232022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome antimalarial Antimalarial drugs artemisone bind binding binding affinity bio-layer interferometry Cell complex Compound coronavirus docking study drug Drug repurposing Human human Angiotensin-converting enzyme in silico in vitro indicated inhibit Interaction interaction pattern interfere Invasion Ligand molecular dynamics Molecular dynamics simulation predicted pyronaridine RBD RBD-ACE2 repurposing SARS-CoV-2 small molecule spike Spike protein stability the RBD the receptor-binding domain viral spike protein [DOI] 10.3390/ph14100954 PMC 바로가기 [Article Type] Article
Therapeutic Significance of microRNA-Mediated Regulation of PARP-1 in SARS-CoV-2 InfectionPerspective Published on 2021-09-222022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] 2019-nCoV Cancer caused Cell cellular processes Central nervous system CNS country COVID-19 COVID-19 pandemic disorder DNA damage Drug repurposing Evidence Factor global healthcare homeostasis Hospitalization Host human disease increasingly indicate Infection microRNA miRNA mutant Neuropathology non-coding RNA novel coronavirus SARS-CoV-2 PARP-1 pathogenic pathological outcomes Pathologies pathology Perspective recent finding Regulation RNA viruses SARS-CoV-2 SARS-CoV-2 life cycle Significance significant increase survival therapeutic potential Therapeutics urgency virus [DOI] 10.3390/ncrna7040060 PMC 바로가기 [Article Type] Perspective
Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapiesResearch Published on 2021-09-202022-10-30 Journal: Molecular Biomedicine [Category] COVID-19, [키워드] anticancer antiviral drugs Antiviral effect applied approach AutoDock vina binding energy calculate Compound COVID-19 drug drug candidate Drug repurposing identify in vitro in vivo infected patients inhibitor molecular docking molecular dynamics Molecular dynamics simulation other coronaviruses potential therapy proportion RdRP receptor reported Repurposed drug repurposing RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp shown starting point supplementary material tested the SARS-CoV-2 therapy treating COVID-19 Trial tyrosine utility Virtual screening [DOI] 10.1186/s43556-021-00050-3 PMC 바로가기 [Article Type] Research
Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting VirusesReview Published on 2021-09-162022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] anticancer Antiviral antiviral action Antiviral compounds approach approved Cancer cancer treatment cardiac cardiac steroids clinical trial condition coronavirus COVID-19 digitoxin digoxin drug Drug evaluation Drug repurposing evaluate example failure glycoside heart heart failure host cell interfere lanatoside C mechanism Na+/K+-ATPase ouabain reported repurposing Research SARS-CoV-2 pandemic significantly tested Topic viral life cycle virus entry [DOI] 10.3390/molecules26185627 PMC 바로가기 [Article Type] Review
Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics ApproachesMinireview Published on 2021-09-142022-10-29 Journal: mSystems [Category] COVID-19, [키워드] AIDS antiviral activity antiviral therapy application Compound coronavirus disease COVID-19 current Drug repurposing drug-resistant Epidemics flu Health help Host-directed therapies host-pathogen interaction host-pathogen interactions identify knowledge less limitation pandemic Pathogens powerful tool proteomics Spread Systems biology target tested therapeutic vaccination Viral diseases viral replication viral strains while [DOI] 10.1128/mSystems.00388-21 PMC 바로가기 [Article Type] Minireview
Drug repositioning against COVID-19: a first line treatmentResearch Article Published on 2021-09-142023-07-02 Journal: Journal of biomolecular structure & dynamics [Category] SARS, [키워드] COVID-19 Drug repurposing Molecular dynamics simulation SARS-CoV-2 Virtual screening [DOI] 10.1080/07391102.2021.1977698 PMC 바로가기 [Article Type] Research Article
Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studiesResearch article Published on 2021-09-092022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] acting activity acute respiratory syndrome Analysis Anti-HCV Antiviral approach approval approved drug binding free energy bypasse cathepsin L Cell culture coronavirus Direct docked drug Drug repurposing drugs Evidence hACE2 HCV hepatitis C virus human Angiotensin-converting enzyme IC50 in silico in vitro in vitro study indications Molecular dynamics simulation MPro Pandemics protease Protease inhibitor receptor SARS-CoV-2 SARS-CoV-2 replication shown supported target targets telaprevir therapeutic virus [DOI] 10.1016/j.heliyon.2021.e07962 [Article Type] Research article
Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells인간 세포에서 SARS-CoV-2 복제를 늦추는 용도 변경 약물의 발견Research Article Published on 2021-09-092022-09-10 Journal: PLoS Pathogens [Category] SARS, 바이오마커, 신약개발, [키워드] addition amodiaquine atovaquone Author bedaquiline candidate cell types COVID COVID-19 COVID-19 vaccine COVID-19 vaccines drug Drug repurposing ebastine effective evaluated FDA-approved drugs help hepatocyte hepatocytes human cell human cells Immunity infected cells Infection kidney Liver damage luciferase LY2835219 manidipine measure nLuc panobinostat patients with COVID-19 performed Protein Proteinuria proximal tubule proximal tubule cell proximal tubule cells reduced replication Replication reported Repurposed drug Repurposed drugs required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Screen Spike protein Support the disease the Spike Therapeutics treat treated Treatment utility Vero Cell Vero cells Viral Viral load virus virus replication Vitamin D3 [DOI] 10.1371/journal.ppat.1009840 PMC 바로가기 [Article Type] Research Article