Bacillus subtilis and surfactin inhibit the transmissible gastroenteritis virus from entering the intestinal epithelial cellsResearch Articles Published on 2017-03-072022-10-28 Journal: Bioscience Reports [Category] Coronavirus, [키워드] addition aminopeptidase N Analysis Antiviral APN Apoptosis apoptotic cells B. subtilis Bacillus subtilis Bacillus subtilis OKB105 candidate Cell coronavirus declined develop dose-dependent manner EGFR ENhance Entry epidermal epithelial cell epithelial cell line experiment expression gastroenteritis growth factor host cell in vitro indicated Infection inhibit intestinal intestinal epithelial cell mechanisms Particle Pathogens performed Plaque assay Protein receptor receptors reduce reducing surfactin target TGEV Toll-like receptor up-regulating viral entry virus western blotting [DOI] 10.1042/BSR20170082 PMC 바로가기 [Article Type] Research Articles
Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profilesResearch Article Published on 2017-02-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Activation association bronchitis changes CMI downregulation early immune response epithelial cell expression expression profile Genotype IBV immune immune modulatory immune response Increased Infectious Bronchitis Virus Inflammatory isolate kidney lesion local immune response lower expression mechanism Morphological Pathogenesis pathological change pathway pro-inflammatory response profile renal replicate Replication response responses TLR7 tracheal upper respiratory tract Viral load viral replication virulence virus [DOI] 10.1371/journal.pone.0172275 PMC 바로가기 [Article Type] Research Article
Cellular entry of the porcine epidemic diarrhea virusArticle Published on 2016-06-152022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] Americas aminopeptidase N Asia binding binding activity carbohydrate Cell coronavirus Culture determine diarrhea domain East epidemic diarrhea epithelial cell Factor functional glycoprotein host cell in vitro in vivo Infection initial Interaction medium membrane fusion N-terminal observation outbreak PED PEDV Porcine epidemic diarrhea virus protease Protein proteolytic activation receptor receptor interaction replicate reported resulting S protein S proteins sialic acid Sialic acid binding small intestine spike subsequent target cell the S protein tissue tropism trimer villus virus virus entry virus infection virus tropism [DOI] 10.1016/j.virusres.2016.05.031 PMC 바로가기 [Article Type] Article
Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signalingReview Published on 2016-05-192022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] Antiviral antiviral cytokine Antiviral innate signaling appear coronavirus diarrhea enteric Enteric coronavirus epidemic diarrhea epithelial epithelial cell epithelial cells Evidence feature gastroenteritis Gut high mortality Host host innate immunity IFN IFN antagonist IFN-α/β IFN-λ immune evasion infect Infection innate immune Innate immunity interferon Interferon regulation intestinal intestinal epithelia intestinal epithelial cell maintain modulate modulation mucosal surface Neonatal nsp1 PEDV Porcine deltacoronavirus Porcine epidemic diarrhea virus Signaling small intestine TGEV These viruses turn Type Type III IFN type III interferon virus viruses watery [DOI] 10.1016/j.virusres.2016.05.015 PMC 바로가기 [Article Type] Review
SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathwayArticle Published on 2016-05-132022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] A549 cells Activation Analysis binding site dependent activation dose epithelial cell expression Genes human lung in vitro in vivo indicated induce inhibitor injection luciferase reporter assay lung lung tissues Macrophage infiltration MAPK mechanism Mouse models NF-κB nuclear translocation Papain-like protease pathway Plasmid PLPro pro-fibrotic promoter promoter region reduced response responsible ROS SARS Coronavirus SARS-CoV significantly siRNA STAT3 stimulated TGF-β1 transcription factor triggered triggering up-regulate up-regulating vimentin [DOI] 10.1038/srep25754 PMC 바로가기 [Article Type] Article
Mitophagy in TGEV infection counteracts oxidative stress and apoptosisResearch Paper Published on 2016-05-102022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] addition antioxidant Apoptosis autophagy caused Cell Complete coronavirus counteract diarrhea DJ-1 epithelial cell expressed homeostasis induce Infection inhibit Injury intestinal epithelia cells intestinal epithelial cell mitochondrial mitophagy morphology observé oxidative stress pathological change Perspective promote Quality control ROS suppress survival TGEV transmissible gastroenteritis virus Treatment upregulation viral infection viral nucleocapsid protein virus infection watery [DOI] 10.18632/oncotarget.8345 PMC 바로가기 [Article Type] Research Paper
A systems approach to understanding human rhinovirus and influenza virus infectionArticle Published on 2015-10-062023-06-23 Journal: Virology [Category] 신종인플루엔자, [키워드] Co-infection epithelial cell Gene expression time-course Influenza virus rhinovirus [DOI] 10.1016/j.virol.2015.08.014 PMC 바로가기 [Article Type] Article
Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathwayResearch Published on 2015-08-182022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Activation adapter African green monkey antiviral immune response blockade blocked cell line damaged demonstrated digestive disorders epidemic diarrhea epithelial cell expression Host identify IFN IFN-β immune cell population immune function in vitro in vivo induce Infection inhibit inhibited inhibitor of κB innate immune system Interaction interferon Intervention intestinal epithelia intestinal epithelial cell intestinal epithelial cells investigated kidney kinase-ε lack Limited mechanism molecular mechanism NF-κB nuclear offered Pathogenesis pathway PEDV promoter Regulatory Result RIG-I signaling pathway target cell transcription factors Type type I interferon upstream Vero Cell virus were used [DOI] 10.1186/s12985-015-0345-x PMC 바로가기 [Article Type] Research
Avian Influenza Virus Infection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pHArticle Published on 2015-04-242023-06-02 Journal: The Journal of Biological Chemistry [Category] 조류인플루엔자, [키워드] Avian influenza virus endosomal pH endosome epithelial cell hemagglutinin membrane fusion tropism Viral protein virus entry [DOI] 10.1074/jbc.M114.611327 PMC 바로가기
Reconstituted Human Polyclonal Plasma-derived Secretory-like IgM and IgA Maintain the Barrier Function of Epithelial Cells Infected with an Enteropathogen재구성된 인간 다클론 혈장 유래 분비형 IgM 및 IgA는 장병원체에 감염된 상피세포의 장벽 기능을 유지한다.journal-article Published on 2014-08-012024-07-30 Journal: Brain stimulation [Category] 세균성이질, [키워드] Cell invasion chemokine confocal microscopy cytokine induction epithelial cell host-pathogen interaction [DOI] 10.1074/jbc.M114.549139 [Article Type] journal-article