Federated deep learning for detecting COVID-19 lung abnormalities in CT: a privacy-preserving multinational validation studyArticle Published on 2021-03-292022-10-04 Journal: NPJ Digital Medicine [Category] 치료기술, [키워드] abnormality aggregation Algorithm automated Chest CT China clinically Computed tomography conducted country COVID-19 COVID-19 pandemic database datasets deep learning develop Diagnosis Diagnostic markers distribution effective external validation feasibility Generalizability Germany heterogeneity Hong Kong hospital hospitalized COVID-19 patients independent dataset lung abnormality mainland management mechanism Pandemics Patient patient data recruited robust Seven the disease validation study [DOI] 10.1038/s41746-021-00431-6 PMC 바로가기 [Article Type] Article
Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection보완 과잉 활성화 및 소비는 SARS-CoV-2 감염의 병원 내 사망률을 예측합니다Clinical Trial Published on 2021-03-252022-08-13 Journal: Frontiers in Immunology [Category] SARS, 임상, [키워드] 95% CI accompanied Activation advanced disease analyzed anaphylatoxin anaphylatoxin C3a C-reactive protein C3a/C3 caused characteristic classical pathways clinical complement Complement activation complement activation and consumption complement inhibitory drug complement inhibitory drugs complement profile complement system Consumption coronavirus coronavirus disease coronavirus disease (COVID-19) covariate COVID-19 COVID-19 related mortality COVID-19 severity Cox model decrease enzyme-immunoassays Evidence Factors ferritin hemolytic hemolytic titration hospital Hospital stay Hospitalized hospitalized COVID-19 patients implicated In-hospital in-hospital mortality Increased Inflammation interleukin interleukin-6 marker Mortality objective Ordinal Scale outcome Outpatient overactivation Pathogenesis patients died PCR-confirmed COVID-19 predictor Primary outcome prospective cohort study Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus secondary outcome severity severity of COVID-19 significantly Support the disease the WHO Thromboinflammation Treatment treatment of COVID-19 turbidimetry uncontrolled were measured WHO ordinal scale [DOI] 10.3389/fimmu.2021.663187 PMC 바로가기 [Article Type] Clinical Trial
Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 PatientsArticle Published on 2021-03-242022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Affect Bacterial Cell COVID COVID-19 COVID-19 patient COVID-19 testing Duration estimates evaluated Evidence explain greater hazard help Hospital admission hospitalized COVID-19 patients immune response Increasing Infection intervals involved Kaplan–Meier Level male male serum testosterone men modeling multivariable Cox regression negativity Oxygen administration pandemic positive COVID-19 Predictive preliminary finding randomized trials Ratio reduced risk factor serum subsequent susceptibility Testing Testosterone the log-rank test total testosterone viral clearance viral infections viral positivity duration [DOI] 10.3390/diagnostics11040581 PMC 바로가기 [Article Type] Article
Characteristics and comparative clinical outcomes of prisoner versus non-prisoner populations hospitalized with COVID-19Article Published on 2021-03-222022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] 30-Day mortality 95% CI 95% confidence interval adjusted age clinical Clinical outcome Cohort confirmed case COVID-19 COVID-19 case Diseases elevated Fever hazard ratio Henry Ford hospital Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients Hypoxemia ICU ICU admissions In-hospital death in-hospital mortality incarcerated individuals inflammatory markers intensive care Intubated intubation Intubation rates Logistic regression males Medical research Mortality Odds ratio outcome patients patients hospitalized paucity of data Population Primary outcome Primary outcomes prison Prisoner required Risk factors System tachypnea the United State Vasopressor were used with COVID-19 [DOI] 10.1038/s41598-021-85916-w PMC 바로가기 [Article Type] Article
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trialCOVID-19에 대한 이트라코나졸: 전임상 연구 및 개념 증명 무작위 임상 시험Randomized Controlled Trial Published on 2021-03-192022-08-13 Journal: EBioMedicine [Category] MERS, SARS, 비임상, 신약개발, 임상, 진단, 치료제, [키워드] 7-point ordinal scale 95% CI absence acute infection acute SARS-CoV-2 infection adequate plasma antifungal drug itraconazole antivirals assigned breath Caco-2 clinical status Clinical studies clinical study clinical trial COVID-19 cumulative score did not reduce drug concentrations Drug repurposing effective evaluated finding foundation funding geometric Geometric means Health Organization Horizon hospitalized COVID-19 patient hospitalized COVID-19 patients human Caco-2 cells ileum in vitro activity initial interim analysis itraconazole Leuven lung Lungs Melinda Gate Melinda Gates not effective Open-label Ordinal Scale outcome Preclinical preclinical studies preclinical study premature termination Prevent prevention of COVID-19 Primary outcome proof-of-concept clinical study randomized clinical trial Randomly required SARS-CoV-2 SARS-COV-2 infection showed no signal single-center study Standard of care Stool stools Transmission Transmission model Treatment Vero Viral Viral load viral load in lungs Viral transmission World Health Organization [DOI] 10.1016/j.ebiom.2021.103288 PMC 바로가기 [Article Type] Randomized Controlled Trial
Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patients hospitalized for COVID-19Observational Study Published on 2021-03-182022-10-04 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] 25-hydroxyvitamin D Admission association baseline Clinical improvement clinical outcomes Comorbidities conducted correlated correlation COVID-19 D-dimer disease severity dose ferritin Hospitalized hospitalized COVID-19 patients ICU admission immunomodulatory effect Infectious diseases Inflammatory marker inflammatory markers LDH median Mild Mortality not significantly different oral cholecalciferol outcome outcomes oxygen Oxygen requirement parathormone Patient patients patients hospitalized proportion PTH recruited serum Severe case severe cases severe disease significantly significantly higher the WHO treated VDD viral infection vitamin D deficiency with COVID-19 [DOI] 10.1038/s41598-021-85809-y PMC 바로가기 [Article Type] Observational Study
COVID-19 Evidence Accelerator: A parallel analysis to describe the use of Hydroxychloroquine with or without Azithromycin among hospitalized COVID-19 patientsCOVID-19 Evidence Accelerator: 입원한 COVID-19 환자에서 아지트로마이신을 포함하거나 포함하지 않은 하이드록시클로로퀸의 사용을 설명하기 위한 병렬 분석Research Article Published on 2021-03-172022-09-10 Journal: PLoS ONE [Category] SARS, 치료제, [키워드] Accelerator adjust adverse event adverse events Analysis Azithromycin best collaboration Combination COVID-19 COVID-19 pandemic Cox proportional hazard Cox proportional hazards models Data science data set data sets Effectiveness EHR Electronic health record elevated Epidemiology Evidence examined FDA foundation frequencies Friend friends health record health system hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Hydroxychloroquine Mortality no effect Patient pharmaceutical intervention Pharmaceutical interventions proportional hazards models Regulatory Research Result risk Seven significantly treat treated Treatment treatment group treatment groups treatment of COVID-19 use of hydroxychloroquine were used [DOI] 10.1371/journal.pone.0248128 PMC 바로가기 [Article Type] Research Article
The in-vitro effect of famotidine on sars-cov-2 proteases and virus replicationArticle Published on 2021-03-082022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] 3CL pro Administered analyzed antiviral activity antiviral drug approved assays bind cell lines clinical study Concentration coronavirus cough COVID-19 COVID-19 pandemic direct-acting Drug discovery function High dose hospitalized COVID-19 patients human cell improvement in silico In-vitro inhibit inhibitor intubation lack Lungs Medicine Mild moderate molecular mechanism Molecular medicine Mortality potential molecular protease Proteases reduced retrospective SARS-CoV-2 SARS-CoV-2 replication Shortness of breath Symptom target tested Treatment virus replication while [DOI] 10.1038/s41598-021-84782-w PMC 바로가기 [Article Type] Article
Folate Levels in Patients Hospitalized with Coronavirus Disease 2019Article Published on 2021-03-022022-10-30 Journal: Nutrients [Category] COVID-19, [키워드] Acute kidney injury association cell metabolism center clinical outcomes consecutive patient consequence COVID-19 COVID-19 patients diagnosed with COVID-19 electronic medical record Epidemic evaluate folate folate deficiency Folic acid folic acid deficiency Follow-up Hospital stay Hospitalized hospitalized COVID-19 patients hospitalized patient Hypoxemia incidence Infection invasive ventilation Level Mortality outcome pathologic Patient patients hospitalized Prevalence prognostic quartile required retrospective cohort study SARS CoV-2 serum significant difference study population with COVID-19 [DOI] 10.3390/nu13030812 PMC 바로가기 [Article Type] Article
Clinical features and risk factors of COVID-19-associated liver injury and function: A retrospective analysis of 830 cases코로나19 관련 간 손상의 임상적 특징과 위험인자 및 기능: 830건의 후향적 분석Article Published on 2021-03-012022-09-11 Journal: Annals of hepatology [Category] MERS, SARS, 바이오마커, [키워드] 95% confidence interval abnormality Admission aims Alanine Alanine transaminase ALT Analysis aspartate Aspartate transaminase AST AST/ALT Betacoronavirus Biochemistry C-reactive protein C-reactive protein (CRP Causality change clinical Clinical features Cohort comparison Computed tomography COVID-19 patients CRP level CRP levels demographic determine Diagnostic Criteria drug Drug induced liver injury elevated exhibited Factor feature groups hepatic Hepatic insufficiency hospitalized COVID-19 patient hospitalized COVID-19 patients incidence information Laboratory testing liver Liver injury lymphocyte multivariable logistic regression Multivariable regression Odds ratio on admission outcome parameter Patient performed Pneumonia potential risk proportion ranged Retrospective analysis risk factor Risk factors tomography Triglyceride was used were used X-ray [DOI] 10.1016/j.aohep.2020.09.011 PMC 바로가기 [Article Type] Article