intranasal

[키워드] absence Activation acute respiratory syndrome Adaptive immune response animal models ARDS Bacterial cascade chemokine chemokines complement contributed controls coronavirus Coronavirus infection Critical cytokine Defense disease distress dysfunction effective exhibited fungal infections high-titer virus Host human infection identify immune Immune cell infiltration Infection Inflammatory cytokine inflammatory monocyte inhibiting intranasal investigated less lung Lung pathology mice mouse-adapted SARS-CoV neutrophil observation outbreak outcome outcomes Pathogenesis pathologic pathology pattern recognition receptor Proinflammatory response Protective reduced regulate relative Replication respiratory Respiratory disease respiratory viruses SARS-CoV SARS-CoV infection sera Severe case Signaling significantly stimulate subsequent syndrome systemic inflammation therapeutic These data Treatment Viral load weight loss
[DOI] 10.1128/mBio.01753-18 PMC 바로가기 [Article Type] Research Article