Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2
Physiology
[키워드] ACE2
ACE2 expression
acute lung injury
acute respiratory syndrome
addition
aerosol
aerosol exposure
Aerosols
Alter
alteration
Altered
angiotensin-converting enzyme 2
BAL
C57BL/6
CD1
CD177
CD4
CD4 T cells
cell activation
change
changes in
chronic
component
concern
Conventional
coronavirus
coronavirus disease
COVID-19
Defense
demonstrated
E-cigarette
Epidemic
form
Gene Expression
Gene expression analysis
GSE
hierarchical clustering
higher risk
Host
host cells
host response
host susceptibility
IgA
immune
Immunoglobulin
immunomodulation
impairment
increase
infect
Infection
Inflammation
Inflammatory
inflammatory disorder
inflammatory pathways
inhalation
involved
Lipidomics
lung
lung disorders
Lung injury
Lungs
mice
moderate
monocyte
neutrophil
neutrophil activation
Neutrophils
occurred
pathogen
profile
receptor
reduced
reductions in
response
RNAseq
SARS-CoV-2
SARS-COV-2 infection
smoker
smoking
state
suggested
susceptibility
upregulation
vaping
[DOI] 10.3389/fphys.2021.649604 PMC 바로가기 [Article Type] Physiology
[DOI] 10.3389/fphys.2021.649604 PMC 바로가기 [Article Type] Physiology