Lessons From the First Wave of COVID-19: Work-Related Consequences, Clinical Knowledge, Emotional Distress, and Safety-Conscious Behavior in Healthcare Workers in SwitzerlandPsychology Published on 2021-02-092022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] adherence assigned Asymptomatic case Behavior Better binding changed clinical Clinical knowledge coronavirus disease COVID-19 cross-sectional survey dimensions Disease progression distress drugs Effect Effectiveness emotional emotional distress equipment First wave Government Health Healthcare system healthcare worker Healthcare workers hygiene increase in Infectious disease information knowledge lack lesson life-threatening lowest Mental mental health MOST National overcome pandemic participant Patient patients physical physical contact prevalent prevention Protective Quantitative questionnaire Regulation reported risk Risk perception significantly lower significantly more Stress structures Switzerland Symptom the disease Transmission Wave work situation worker [DOI] 10.3389/fpsyg.2021.628033 PMC 바로가기 [Article Type] Psychology
Substance use and substance use disorder, in relation to COVID-19: protocol for a scoping reviewCOVID-19와 관련된 물질 사용 및 물질 사용 장애: 범위 검토를 위한 프로토콜Review Published on 2021-02-032022-08-31 Journal: Systematic Reviews [Category] MERS, 변종, 치료제, [키워드] Abstract affected aggravate alcohol Analysis articles Asian cannabis change CINAHL clinical clinical trial Collection conducted core coronavirus coronavirus disease COVID-19 COVID-19 pandemic creating Data analysis disaster disorder engage English language for inclusion frequencies global health Google Scholar greater Grey literature Health Organization healthcare help index Index Medicus international standard Joanna Briggs Institute literature manual middle mitigate monitoring number Nursing open Open Science Framework opioids original pandemic Population protocol PsycINFO Quantitative registry Research resulting review risk smoke social changes Standard structures substance Substance use Substance use disorder SUD supplementary material thematic analysis variant variants Web of Science WHO World Health Organization [DOI] 10.1186/s13643-021-01605-9 PMC 바로가기 [Article Type] Review
De novo design and bioactivity prediction of SARS-CoV-2 main protease inhibitors using recurrent neural network-based transfer learningResearch Article Published on 2021-02-022022-10-27 Journal: BMC Chemistry [Category] COVID-19, [키워드] absence accelerate active against acute respiratory syndrome addition Antiviral antivirals approved artificial intelligence baseline binding Bioactivity can be used caused Classifier Compound coronavirus coronavirus disease COVID-19 COVID-19 pandemic de novo de Novo drug design deep learning displaying drug candidates Drug discovery Generative model global pandemic Human identify in viral inhibitor inhibitors inhibitors of SARS-CoV-2 Interaction M pro methodology molecular docking nine offer overlap physicochemical property platform predicted protease Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro screened structures transfer transfer learning Treatment Ulmfit Vaccine [DOI] 10.1186/s13065-021-00737-2 PMC 바로가기 [Article Type] Research Article
The impact of COVID-19 on systemic anticancer treatment delivery in ScotlandBrief Communication Published on 2021-02-022022-10-04 Journal: British Journal of Cancer [Category] MERS, SARS, 치료법, [키워드] anticancer approach Breast cancer cancer centre cancer patient Cancer patients Care Chemotherapy clinician Colorectal cancer consequence COVID-19 COVID-19 pandemic decrease facilitated initial magnitude National NHS occurred oncology Patient reduction in reflected Regional regions SACT Scottish structures subsequent Support therapy Treatment understanding Variation [DOI] 10.1038/s41416-021-01262-8 PMC 바로가기 [Article Type] Brief Communication
A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2Spike RBD와 ACE2 간의 상호 작용 차단을 통한 항 SARS-CoV-2 약물의 새로운 스크리닝 전략Article Published on 2021-02-012022-08-31 Journal: Environment international [Category] MERS, SARS, 치료제, [키워드] ACE2 activity angiotensin angiotensin converting enzyme anti-SARS-CoV-2 Anti-SARS-CoV-2 drugs screening strategy binding binding energy blockade Blockade mechanism Compound compounds Corona drug drug design Drug screening druggability eight enzyme exhibited hACE2 hesperidin highest human angiotensin converting enzyme 2 information Interaction investigated mechanism overcome pandemic RBD Receptor binding domain required S RBD SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD screening strategy spike Spread Structure Structure-activity relationship structures therapy Virus Disease [DOI] 10.1016/j.envint.2020.106361 PMC 바로가기 [Article Type] Article
Estimating the time-varying reproduction number of COVID-19 with a state-space method상태 공간 방법으로 COVID-19의 시변 재생산 수 추정Research Article Published on 2021-01-292022-09-10 Journal: PLoS Computational Biology [Category] MERS, 변종, 치료기술, [키워드] adopted automatically average can be used capture caused change confirmed cases consequence country COVID-19 COVID-19 infections Critical dataset decrease defined dependent on despair detect disease distribution Effect event Hope Incubation period Infection information mathematical mathematical model measure Measures media MONITOR Novel coronavirus predict Reproduction number risk of infection Society Spread structures the times Transmission variant [DOI] 10.1371/journal.pcbi.1008679 PMC 바로가기 [Article Type] Research Article
The SARS-Coronavirus Infection Cycle: A Survey of Viral Membrane Proteins, Their Functional Interactions and PathogenesisReview Published on 2021-01-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] activity adaptive Analysis antiviral therapy approach Betacoronavirus cell death cellular complement Coronaviridae coronavirus coronavirus disease CoV COVID-19 Disease progression DNA vaccines envelope Epidemic function functions Genome growth Health Host immune immune response Immunity include Infection infection process Inflammation influences on information membrane membrane protein MERS-CoV Middle East Mortality multifunctional nonstructural protein offer Other overlap pandemic Pathogenesis Pathways Perspective Protein Proteins purified Region respiratory responsible resulting SARS-CoV-1 SARS-CoV-2 sequence similarity severe disease Stage structural proteins structures survey the Coronaviridae the SARS-CoV-2 genome transmembrane protein transmembrane proteins Vaccine development Vaccines viral replication virus viruses while [DOI] 10.3390/ijms22031308 PMC 바로가기 [Article Type] Review
Implementation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 (REMAP-COVID) trial in a US health system—lessons learned and recommendations미국 의료 시스템에서 COVID-19용 무작위 임베디드 다인자 적응형 플랫폼(REMAP-COVID) 시험 구현 - 교훈 및 권장 사항Methodology Published on 2021-01-282022-09-10 Journal: Trials [Category] 임상, 치료제, [키워드] Adaptive platform trial Adaptive trial adverse event aligning alignment approval central institutional review board clinical care Clinical research clinical trial Compliance coordination coronavirus COVID-19 Data collection Efficiency Electronic health record Embedment Enrollment export facilitated feasible Health health system Healthcare system hospitalized patient hospitalized patients implementation institutional review board integration leadership management Modification offer Platform trial promote recommendation Regulatory remote Research Result routine care SARS-CoV-2 structures Trial vision with COVID-19 [DOI] 10.1186/s13063-020-04997-6 PMC 바로가기 [Article Type] Methodology
In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh방글라데시에서 병원체의 근원과 다양성을 결정하기 위한 SARS-CoV-2의 in silico 비교 게놈Research Article Published on 2021-01-202022-08-13 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] affected Analysis caused China Clusters coding region Comparative analysis conducted country COVID19 D614G determine epidemiological France Genome genomic variation genomic variations indicated isolate isolates leads Missense Missense mutation Missense mutations Mutation NSP2 pandemic pathogen Phylogenetic analysis predict predicted prevalent Protein protein structures reported SARS-CoV-2 SARS-CoV-2 genomic sequences SARS-CoV-2 isolate SARS-CoV-2 sequence SARS-CoV-2 virus Saudi Arabia Spike protein strain Strains structures the spike protein transmission route United Kingdom virus viruses Whole-genome sequence whole-genome sequences [DOI] 10.1371/journal.pone.0245584 PMC 바로가기 [Article Type] Research Article
Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans인간 병원체 크립토코커스 네오포르만스와 크립토코커스 데네오포르만스 사이의 종 경계를 강화하는 요인Research Article Published on 2021-01-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Alternative pathway Aneuploidy Bacterial block component Cryptococcus Cryptococcus neoforman Cryptococcus neoformans deleting determine DNA DNA sequence DNA sequences eukaryote eukaryotes Factor fecundity Frequency fungal Genetic genetic recombination human pathogen hybrid hybridization identify increase in incubated instance interspecific interspecific hybrid interspecific hybrids isolate lack lead limit Loss maintain mechanism medium meiosis meiotic recombination Msh2 parent parental parents pathogenic pathway phenotype Previous studies previous study produced progeny Recombination Sequencing sexual reproduction strain Structure structures transgressive phenotype transgressive phenotypes unique Variation viability whole-genome whole-genome sequencing yeast [DOI] 10.1371/journal.pgen.1008871 PMC 바로가기 [Article Type] Research Article