Possible Link between Higher Transmissibility of Alpha, Kappa and Delta Variants of SARS-CoV-2 and Increased Structural Stability of Its Spike Protein and hACE2 AffinitySARS-CoV-2의 알파, 카파 및 델타 변이체의 더 높은 투과율과 스파이크 단백질 및 hACE2 친화도의 구조적 안정성 증가 사이의 가능한 연결Article Published on 2021-08-242022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] (Alpha) acute respiratory syndrome coronavirus affinity Alpha Alpha variant B.1.1.7 B.1.617.1 B.1.617.2 binding affinity binding energy caused complexes coronavirus coronavirus 2 COVID-19 Delta Delta variants E484Q false negativity global pandemic globe hACE2 hydrogen Immune escape increase in Increased Infection Interaction interactions L452R Lineage molecular molecular dynamic simulations molecular mechanism mutant mutants Mutation mutation rate N501Y N501Y mutation Neutralizing antibodies neutralizing antibody outbreak PCR tests performed Perspective provide rationale Receptor binding Receptor binding domain Reinfection respiratory RT-PCR tests SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increase spike Spike protein spike variants stability T478K T478K and L452R mutation the spike protein transmissivity variants virus wild-type SARS-CoV-2 wildtype [DOI] 10.3390/ijms22179131 PMC 바로가기 [Article Type] Article
The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452RArticle Published on 2021-08-232022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Alpha variant Critical Delta demonstrated disease spread effort Epsilon independent individual Infection L452R Lineage Local Mutation neutralization neutralization capacity outbreak Prevent pseudoviruses reduction in SARS-CoV-2 SARS-CoV-2 variant Sequencing sera shown Surveillance the Spike vaccination variant wild-type strain [DOI] 10.3390/vaccines9080937 PMC 바로가기 [Article Type] Article
Severe SARS-CoV-2 Breakthrough Reinfection With Delta Variant After Recovery From Breakthrough Infection by Alpha Variant in a Fully Vaccinated Health WorkerMedicine Published on 2021-08-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute phase reactants Alpha variant blood test breakthrough Breakthrough infection breakthrough infections breakthrough reinfection caused chest imaging clinical care clinical history Complete concern COVID-19 Delta delta variant Hospitalization hypoxia Immunity index case Infection Mild occurred Patient positive sample post vaccination Reinfection retrieved RT-PCR SARS-CoV-2 SARS-CoV-2 infections Sequencing Seroconversion serology Seven supported the patient vaccination VoC WGS whole genome Whole genome sequencing worker [DOI] 10.3389/fmed.2021.737007 PMC 바로가기 [Article Type] Medicine
The Alpha Variant (B.1.1.7) of SARS-CoV-2 in Children: First Experience from 3544 Nucleic Acid Amplification Tests in a Cohort of Children in Germany어린이의 SARS-COV-2의 알파 변이 (B.1.1.7) : 독일 어린이 코호트에서 3544 핵산 증폭 검사에서 첫 경험Article Published on 2021-08-122022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, [키워드] acid Alpha Alpha variant Analysis analyzed B.1.1.7 children Clinical course collected cough Course courses COVID-19 Ct value Ct-value disease Evidence experience Fever Germany Infection infectiousness information investigated less median nucleic acid nucleic acid amplification Pediatric patient Pediatric patients positive Questionnaires retrospective Retrospective analysis rhinitis SARS-CoV-2 SARS-COV-2 infection severe symptom Spread suffered Swab Symptom symptomatic Symptoms Test tested the SARS-CoV-2 wild type [DOI] 10.3390/v13081600 PMC 바로가기 [Article Type] Article
Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) VariantB.1.617.2(델타) 변종에 대한 Covid-19 백신의 효과Article Published on 2021-08-122022-09-11 Journal: The New England Journal of Medicine [Category] SARS, 변종, 치료기술, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant B.1.1.7 B.1.617.2 BNT162b2 BNT162b2 vaccine Case-control cause caused ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine circulating contributed coronavirus coronavirus disease Coronavirus disease 2019 Delta delta variant dose Effectiveness effort England first dose globe increase in India notable populations predominant proportion Public Public Health England receipt SARS-CoV-2 sequenced Sequencing severe acute respiratory syndrome Coronavirus Support symptomatic symptomatic disease the patient United Kingdom vaccination Vaccination Status Vaccine vaccine doses Vaccines variant variants virus were used [DOI] 10.1056/NEJMoa2108891 PMC 바로가기 [Article Type] Article
Molecular Epidemiology of SARS-CoV-2 in Diverse Environmental Samples GloballyArticle Published on 2021-08-102022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] A570D acute respiratory syndrome Alpha Alpha variant amino acid substitution Analysis analyzed B.1 B.1.1 B.1.1.7 China circulating Community Contamination coronavirus country COVID-19 COVID-19 case Czech Republic D614G detect Epidemiology Genetic genomic Germany GISAID highest Human Italy Lineage Mutation Netherlands Other Outbreaks P681H pandemic percentage Phylogenetic analysis prevalent lineage Prevent recorded reported S982A Sample SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 virus sequence sewage Slovenia Spike protein strain Surveillance Switzerland T716I Treatment variant virus genome wastewater [DOI] 10.3390/microorganisms9081696 PMC 바로가기 [Article Type] Article
Novel Nested-Seq Approach for SARS-CoV-2 Real-Time Epidemiology and In-Depth Mutational Profiling in WastewaterSARS-CoV-2 실시간 역학 및 폐수의 심층 돌연변이 프로파일링을 위한 새로운 Nested-Seq 접근 방식Article Published on 2021-08-072022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] (RdRp 2019-nCoV Alpha variant amplification Analysis applied approach caused clinical sample clinical samples Combination COVID-19 D614G DNA sequencing effective Epidemiology Frequency genomic variants indicated lack Modification Molecular assay National nested PCR novel P323L pandemic PCR assays platform predicted Prevalence Profiling quantification RdRP Real-time monitoring Region regions reverse transcription RNA stability SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 NGS SARS-CoV-2 RNA SARS-CoV-2 sequencing SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequencing data sewage significantly Spike protein Treatment variant variants wastewater Wastewater-based epidemiology with COVID-19 [DOI] 10.3390/ijms22168498 PMC 바로가기 [Article Type] Article
Hypothesis: Possible influence of antivector immunity and SARS‐CoV‐2 variants on efficacy of ChAdOx1 nCoV‐19 vaccine가설 : Chadox1 NCOV -19 백신의 효능에 대한 항 바이터 면역 및 SARS -COV -2 변이체의 영향Perspective Published on 2021-07-312022-09-10 Journal: British Journal of Pharmacology [Category] SARS, 변종, [키워드] adoption Alpha Alpha variant appear applied booster dose ChAdOx1 consequence Efficacy environmental conditions Evolution homologous Immunity Influenza virus interfere less Longitudinal studies longitudinal study maintain mass vaccination moment pandemic physical physical prevention preventive measures provide reduce repeated SARS‐CoV‐2 SARS‐CoV‐2 variants second severity of symptom suggested Transmissibility turn vaccinated individual vaccinated individuals vaccination Vaccination strategy Vaccine vaccine efficacy variant viral vectors [DOI] 10.1111/bph.15620 PMC 바로가기 [Article Type] Perspective
Infectivity Upsurge by COVID-19 Viral Variants in Japan: Evidence from Deep Learning Modeling일본의 COVID-19 바이러스 변종에 의한 감염성 증가: 딥 러닝 모델링의 증거Article Published on 2021-07-222022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, [키워드] (Alpha) adjust adopted Alpha Alpha variant analyzed average B.1.1.7 caused COVID-19 Data analysis deep deep learning demonstrated early stage early stages Effect effective Efficiency Factor Forecasting Health healthcare facility hospitals in some Infectivity Japan learning machine-learning modeling morbidity morbidity rates new strain new virus positive reported Reproduction number training data variant variants Viral viral variant Viral variants virus spread was used [DOI] 10.3390/ijerph18157799 PMC 바로가기 [Article Type] Article
Increased Transmissibility of the SARS-CoV-2 Alpha Variant in a Japanese Population일본 인구에서 SARS-CoV-2 알파 변이체의 전염성 증가Article Published on 2021-07-222022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, [키워드] 95% CI Alpha Alpha variant Analysis attack rate attack rates COVID-19 cross-sectional cross-sectional study determine diagnosed dominant Epidemic household contact household contacts Increased index case indicate Japan Japanese N501Y performed Poisson regression Population positive risk robust error variance SARS-CoV-2 secondary attack rate significantly higher the SARS-CoV-2 Transmissibility virus was determined [DOI] 10.3390/ijerph18157752 PMC 바로가기 [Article Type] Article