Developments in Treatment Methodologies Using Dendrimers for Infectious DiseasesReview Published on 2021-05-312022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] antibody Antimicrobial therapy Antiviral agents antiviral therapy Bacteria biochemical Compound contrast agent dendrimer dendrimers development diagnostic diagnostics Diseases drug delivery genetic material Infectious disease Infectious diseases macromolecules medium methodology MRI Nanoparticles parasites peptide polymers potential therapy structural property substrate therapeutic Transport Vaccine viruses [DOI] 10.3390/molecules26113304 PMC 바로가기 [Article Type] Review
Carbonized Lysine-Nanogels Protect against Infectious Bronchitis VirusCommunication Published on 2021-05-212022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] activity alleviate Amino acid Antiviral agents bovine carbonization Cell cell membrane Concentration effective Embryo embryos Fever IBV in vitro indicated Infectious Bronchitis Virus lysine lysine hydrochloride nanogels pathology penetration Prevent resulting Spread virus virus-neutralizing [DOI] 10.3390/ijms22115415 PMC 바로가기 [Article Type] Communication
Therapy with lopinavir/ritonavir and hydroxychloroquine is associated with acute kidney injury in COVID-19 patients로피나비르/리토나비르 및 하이드록시클로로퀸을 사용한 치료는 COVID-19 환자의 급성 신장 손상과 관련이 있습니다Research Article Published on 2021-05-112022-09-10 Journal: PLoS ONE [Category] SARS, 치료제, [키워드] Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect AKI Analysis analyzed Antiviral agents both groups Care control group controls coronavirus coronavirus disease correlation COVID-19 COVID-19 patient COVID-19 patients creatinine CYP3A4 cytochrome P450 enzyme Germany Hospitalized Hydroxychloroquine ICU ICU patient ICU Patients in both group in vitro activity incidence increase in independent risk factor Interaction Kidney function Kidney injury linear linear correlation Lopinavir Lopinavir/ritonavir mechanism Mortality National Early Warning Score NEWS non-ICU non-ICU patients P450 Patient patients R 2 receiving respiratory Result Ritonavir SARS-CoV-2 score serum creatinine severe acute respiratory syndrome Coronavirus severely ill COVID-19 patients severity severity of illness Standard therapy therapy treated Treatment treatment of COVID-19 university university hospital was performed with COVID-19 [DOI] 10.1371/journal.pone.0249760 PMC 바로가기 [Article Type] Research Article
Iminosugar Glucosidase Inhibitors Reduce Hepatic Inflammation in Hepatitis A Virus-Infected Ifnar1-/- MiceArticle Published on 2021-05-102023-05-31 Journal: Journal of Virology [Category] A형 간염, Fulltext, [키워드] Antiviral agents ganglioside hepatitis A virus host response iminosugar liver immunology Miglustat picornavirus [DOI] 10.1128/JVI.00058-21 PMC 바로가기
Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19COVID-19의 잠재적인 치료를 위한 SARS-CoV-2 단백질에 대한 두 가지 말 제형의 개발 및 특성화Article Published on 2021-05-102022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료법, 치료제, [키워드] alterations anti-RBD Anti-S1 anti-SARS-CoV-2 anti-viral antibody antibody Antibody therapy antivenom Antiviral agents Applied immunology bites and stings caprylic acid Clinical efficacy clinical trials convalescent plasma COVID-19 development ELISA equine evaluated exhibited Final horse Hyperimmune plasma immunization immunized Immunochemistry immunoreactivity Immunotherapy in vitro mixture N protein neutralizing capacity outbreak physicochemical polyclonal pool Potential treatment priming profile RBD reached Receptor binding domain recombinant proteins S1 protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SEM tested therapy therapy for COVID-19 treatment for COVID-19 two group two groups Viral [DOI] 10.1038/s41598-021-89242-z PMC 바로가기 [Article Type] Article
Re I Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine ProteaseSARS-CoV-2 주요 시스테인 프로테아제에 대한 배위 공유 억제제로서의 Re I 트리카보닐 복합체Article Published on 2021-05-032022-09-11 Journal: Angewandte Chemie (International ed. in English) [Category] SARS, 치료제, [키워드] 3CL pro Antiviral Antiviral agents attenuate bioinorganic chemistry chymotrypsin complexes Coordinate cysteine cysteine protease disease example impacted inhibitor inhibitors inorganic Inorganic chemistry investigated life majority medicinal inorganic chemistry Mortality outbreak pharmacological protease Protease inhibitor Proteases Quality of life SARS-CoV-2 selective selective inhibition Severe acute respiratory syndrome Spread targets the SARS-CoV-2 Treatment [DOI] 10.1002/anie.202016768 PMC 바로가기 [Article Type] Article
Screening possible drug molecules for Covid-19. The example of vanadium (III/IV/V) complex molecules with computational chemistry and molecular dockingResearch article Published on 2021-05-012022-10-05 Journal: Computational Toxicology [Category] 치료제, [키워드] antiviral activity Antiviral agents candidate complex complexes computational COVID-19 docking drug drug candidate Drug discovery Drug screening example Government infection control Laboratory measure molecular docking Molecular docking study pandemic Proteins Research Screening tested Vanadium [DOI] 10.1016/j.comtox.2021.100157 [Article Type] Research article
Hybrid physiologically-based pharmacokinetic model for remdesivir: Application to SARS-CoV-2렘데시비르에 대한 하이브리드 생리학적 기반 약동학 모델: SARS-CoV-2에 적용Article Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 치료제, [키워드] anti-SARS-CoV-2 Antiviral agents application can be used catastrophic caused Concentration condition conducted coronavirus disease Coronavirus disease 2019 COVID-19 determine effective Extracellular half-maximal effective concentration Health humans hybrid impacted imperative in vitro indicated lung Lungs metabolite mononuclear cell Multiple-dose Novel coronavirus pandemic parameter patients Peripheral blood Peripheral blood mononuclear cells pharmacokinetic prodrug profiles ranged RDV regimen regimens Remdesivir reported SARS-CoV-2 sensitivity analysis Severe acute respiratory syndrome target tissues Therapeutic treatment tissue [DOI] 10.1111/cts.12975 PMC 바로가기 [Article Type] Article
Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coliResearch Article Published on 2021-04-292022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Addgene Antiviral agents antiviral molecule Bacterial caused characterization complex composed Compound coronavirus 2 COVID-19 pandemic death E . coli enzyme Escherichia coli expected expressed expressing expression form functional in vitro insect cells Nsp12 Plasmid produced protocol protocols purification purified RdRP Replication replication of SARS-CoV-2 respiratory RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA Scientific community subunit Transcription variant Viral protein was measured [DOI] 10.1371/journal.pone.0250610 PMC 바로가기 [Article Type] Research Article
Impacts of the Percentage of Basal Core Promoter Mutation on the Progression of Liver Fibrosis After Hepatitis B e Antigen SeroconversionArticle Published on 2021-04-232023-06-13 Journal: The Journal of Infectious Diseases [Category] B형 간염, [키워드] Antiviral agents Hepatitis B virus Liver stiffness measurement transient elastography [DOI] 10.1093/infdis/jiaa545