Multicenter Evaluation of the BioFire Respiratory Panel 2.1 (RP2.1) for Detection of SARS-CoV-2 in Nasopharyngeal Swab Samples비인두 면봉 샘플에서 SARS-CoV-2 검출을 위한 BioFire Respiratory Panel 2.1(RP2.1)의 다기관 평가Multicenter Study Published on 2022-05-182022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adenovirus age Analysis assays BioFire cause Characteristics Concentration coronavirus detection enterovirus exhibited exhibiting expansion groups Hemisphere Human Human rhinovirus imperative incidence include limit of detection multicenter multiplex nasopharyngeal nasopharyngeal swabs overlap Panel pathogen Pathogens positive predominant respiratory respiratory infection respiratory infections respiratory panel 2.1 Respiratory pathogens rhinovirus RP2 Sample SARS-CoV-2 severe acute respiratory syndrome Coronavirus specimen specimens subject target tested [DOI] 10.1128/jcm.00066-22 PMC 바로가기 [Article Type] Multicenter Study
Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor팔미토일에탄올아미드(PEA)는 S 단백질 및 ACE-2 수용체와 상호작용하여 SARS-CoV-2 진입을 억제합니다Article Published on 2022-05-172022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 activate activated adjuvant therapy Antiviral antiviral agent antiviral drug antiviral drugs antiviral potency binding bioactive lipids cascade cause cellular clinical test Clinical tests clinical trial connection Coronaviruses counteract Course COVID-19 COVID-19 pandemic Degradation derangement Disruption drop droplets energy entry receptor event Evidence fatty Fatty acid generate glycoprotein Glycoproteins highlight Huh-7 cells humans in viral Infection Inflammation inflammatory stimuli lack life cycle Lipid lipid droplets lipid metabolism lipids mechanism of action mechanisms membrane metabolism nutraceutical palmitoylethanolamide Pathways PEA Prevent protective effect Protective effects recent replicate Replication Research RNA virus S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein second significantly Spike protein the SARS-CoV-2 therapy Toxicity transcription factor Treatment Usage viral infection viral life cycle virus viruses VSV [DOI] 10.3390/v14051080 PMC 바로가기 [Article Type] Article
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine stormFamotidine은 미주 신경 염증 반사를 활성화하여 사이토카인 폭풍을 약화시킵니다.Article Published on 2022-05-162022-09-11 Journal: Molecular Medicine [Category] 유전자 메커니즘, [키워드] Acetylcholine acetylcholine receptor activate Administered Alpha antagonist Anti-inflammatory anti-inflammatory activity anti-inflammatory effect Anti-inflammatory effects antiviral activity attenuate Blood brain barrier Brain cause Central nervous system characterized cholinergic Cholinergic anti-inflammatory pathway Cimetidine Clinical course Clinical studies clinical study Clinical use concentrations COVID-19 Cytokine storm disease dosage dosages Effect Evidence Famotidine Gastroesophageal reflux gastroesophageal reflux disease Genetic Histamine Histamine receptors ICV IL-6 Inflammatory inhibits inflammation knock-out lipopolysaccharide mast cell Mast cells mechanism mechanism of action mice morbidity and mortality Necrosis observation penetrate Prevent pro-inflammatory cytokine pro-inflammatory cytokine release Ranitidine recent receptor reduced released replicated serum severe COVID-19 Signal transduction Signaling significantly significantly more stimulated survival syndrome TNF treat Tumor tumor necrosis tumor necrosis factor vagus nerve Vagus nerve signaling. were assessed while α7nAChR [DOI] 10.1186/s10020-022-00483-8 PMC 바로가기 [Article Type] Article
Shared genomic architectures of COVID-19 and antisocial behaviorCOVID-19의 공유 게놈 구조와 반사회적 행동Article Published on 2022-05-102022-09-11 Journal: Translational Psychiatry [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggression antisocial antisocial behavior average average income baby calculate cause chronic obstructive chronic obstructive pulmonary disease coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 Diseases estimate exposure to false-discovery rate Genetic genetics Genome-wide association studies Genome-wide association study genomic Health higher risk Linkage disequilibrium matrix measure mind obstructive pulmonary disease omicron overlap pandemic pulmonary disease SARS-CoV-2 severe acute respiratory syndrome Coronavirus text traits Vaccine variant verbal with COVID-19 [DOI] 10.1038/s41398-022-01948-4 PMC 바로가기 [Article Type] Article
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 Research Published on 2022-05-092022-10-05 Journal: Nature metabolism [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accompanied antiviral activity bind Blood cause cellular entry Comorbidity contribute COVID-19 COVID-19 pathogenesis diabete Diabetes Mellitus Diabetic diabetic patient disease severity effective healthy individual identify inhibit mechanism membrane fusion metabolite mice Mortality much higher patients patients with diabete patients with diabetes reduce respiratory tissue S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication serum severe COVID-19 severity significantly lower Spike protein susceptibility the SARS-CoV-2 undergo viral infection Viral load wild-type [DOI] 10.1038/s42255-022-00567-z [Article Type] Research
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamstersArticle Published on 2022-05-092022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome amplified benefit cascade cause circulating pro-inflammatory cytokine Complication complications of COVID-19 coronavirus COVID-19 COVID-19 patients COVID19 Cytokine dysregulation Effect evaluated Extrapulmonary hamster hamsters increasingly induce Infection Inflammatory inflammatory disease information less Long-term follow-up metabolism organ system pathogenesis of SARS-CoV-2 Patient pro-inflammatory Prophylactic respiratory tract SARS-CoV-2 SARS-COV-2 infection skeletal therapeutic intervention tissue tissues vertebrae viral infection [DOI] 10.1038/s41467-022-30195-w PMC 바로가기 [Article Type] Article
Effectiveness of a COVID-19 Additional Primary or Booster Vaccine Dose in Preventing SARS-CoV-2 Infection Among Nursing Home Residents During Widespread Circulation of the Omicron Variant – United States, February 14-March 27, 20222022년 2월 14일-3월 27일, 미국, 2022년 2월 14일-3월 27일, 미국, 2022년 2월 14일-3월 27일Article Published on 2022-05-062022-09-11 Journal: Morbidity and Mortality Weekly Report [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI accounted Ad26 analyzed B.1.1.529 BNT162b2 booster dose booster doses Booster vaccine cause CDC conjunction Coverage COVID-19 COVID-19 vaccination COVID-19 vaccine Decline defined dose Effectiveness eligible greater home Immunocompromised include Infection infection with SARS-CoV-2 isolates Johnson & Johnson morbidity and mortality mRNA mRNA vaccine mRNA-1273 network NHSN Nursing nursing home omicron Omicron variant Pfizer-BioNTech Preventing primary dose PROTECT receipt receive reported resident Safety SARS-CoV-2 sequenced Surveillance United States vaccination Vaccine Vaccine-induced immunity Variability variant variants virus Weekly [DOI] 10.15585/mmwr.mm7118a4 PMC 바로가기 [Article Type] Article
The Current Landscape of mRNA Vaccines Against Viruses and Cancer-A Mini Review바이러스 및 암에 대한 mRNA 백신의 현재 상황-A 미니 리뷰Review Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Against Cancer cancer vaccination cancers cause clinical development clinical trial clinical trials clinical trials of mRNA vaccines COVID-19 pandemic current death example flexible landscape limitation MINI molecular mechanisms mRNA mRNA modifications mRNA vaccine mRNA vaccine delivery mRNA vaccine developers mRNA vaccine mechanism mRNA vaccines mRNA-based multiple antigen multiple antigens Patient Personalized medicine platform Research review therapy Treatment vaccination vaccine platform viral disease viral infection viral infections viral vaccination. viruses [DOI] 10.3389/fimmu.2022.885371 PMC 바로가기 [Article Type] Review
Multisensory mental representation in covid-19 patients and the possibility of long-lasting gustatory and olfactory dysfunction in the CNS코로나19 환자의 다감각적 정신 표현과 CNS에서 오래 지속되는 미각 및 후각 기능 장애의 가능성Article Published on 2022-05-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] activate Alter Brain cause chemosensory CNS COVID-19 COVID-19 adult patient COVID-19 infection COVID-19 negative COVID-19 patient COVID-19 patients dysfunction dysgeusia Gustatory Hyposmia Italian long-lasting Mental mental image neurological manifestation odor olfactory olfactory dysfunction Patient Psychological reduced reported responsible significantly significantly lower status [DOI] 10.1038/s41598-022-11119-6 PMC 바로가기 [Article Type] Article
Rapidly progressive dementias — aetiologies, diagnosis and management Reviews Published on 2022-05-042022-10-05 Journal: Nature reviews. Neurology [Category] 바이오마커, 변종, 진단, 치료제, [키워드] addition aetiology antibody Biomarker cause clinically clinician cognitive condition contribute Dementia diagnosed Diagnosis diagnostic differential diagnoses disease Diseases disorder Encephalopathy epidemiological Factor help heterogeneous High-dose Immune-mediated include management morbidity and mortality neurodegenerative Potential treatment prion protocol reducing review RPD syndrome therapy treatable Treatment utility [DOI] 10.1038/s41582-022-00659-0 [Article Type] Reviews