Instrument-free, CRISPR-based diagnostics of SARS-CoV-2 using self-contained microfluidic system자급식 미세유체 시스템을 사용하여 기기가 필요 없는 CRISPR 기반 SARS-CoV-2 진단Article Published on 2022-03-012022-09-11 Journal: Biosensors & bioelectronics [Category] MERS, SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 cleavage clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPR-Cas12a Critical detect Device diagnostics Diseases electricity hand Hand warmer Infectious diseases instrument Instrument-free molecular diagnostics isothermal amplification lateral flow molecular Nasopharyngeal swab operation other infectious diseases platform point-of-care Rapid reagent respiratory SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA Self-contained microfluidic chip. sensitivity severe acute respiratory syndrome Coronavirus specificity Treatment [DOI] 10.1016/j.bios.2021.113865 PMC 바로가기 [Article Type] Article
Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevitySirt1과 AMPK를 통한 페룰산과 베르베린은 건강한 장수의 세포 정화 촉진제로 작용할 수 있습니다Review Published on 2022-03-012022-09-11 Journal: Open Heart [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] activating Activation AMPK amplify amplifying anthocyanin Anti-inflammatory effects antioxidant Apoptosis appear autophagy bacterial metabolite benefit berberine biogenesis boost carotid carotid artery carotid artery diseases Cell cell survival cellular cellular senescence Chinese clinically complementary Concentration conjunction coronary angiography deficit detect DNA DNA repair echocardiography Effect endothelial ENhance enzyme expression ferulic acid function functions Health health benefits healthy independent Inflammation inhibiting mechanism mediator mitochondrial molecular basis mRNA NAD+ NF-kB nicotinamide Nrf2 nutraceutical Phase 2 promote promoter Protective protective effect protein level protein levels SARS-CoV-2 spike protein SIRT1 Spike protein survival synergistic the SARS-CoV-2 tissues Toxicity transcription factor turn [DOI] 10.1136/openhrt-2021-001801 PMC 바로가기 [Article Type] Review
The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 beta (B.1.351) and other variants of concern in preclinical studiesChAdOx1 벡터화 백신 AZD2816은 SARS-CoV-2 베타(B.1.351) 및 전임상 연구에서 우려되는 기타 변이체에 대해 강력한 면역원성을 유도합니다.Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, [키워드] addition animals antibodies AstraZeneca AZD1222 B.1.351 B.1.617.2 Beta binding booster booster dose Booster vaccine booster vaccines caused ChAdOx1 ChAdOx1-vectored vaccine clinical development clinically Course death Delta dose effort expresse funds Gamma hospitalisation Immunity immunogenic increase in induce MRC mutated Mutation nCoV Neutralising Antibodies neutralising antibody new SARS-CoV-2 omicron other variant over P.1 pandemic preclinical study Proteins reduced regimens Research SARS CoV2 SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 virus single dose Spike protein Support T cell T cell response T cells the spike protein Vaccine Vaccines variants variants of concern vectored vaccine virus isolate was measured [DOI] 10.1016/j.ebiom.2022.103902 PMC 바로가기 [Article Type] Article
Detection of COVID-19 in tears of ICU-admitted patients with SARS-CoV-2 infectionSARS-CoV-2 감염 중환자실 입원 환자의 눈물에서 COVID-19 검출Article Published on 2022-03-012022-09-11 Journal: International ophthalmology [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed association blood tests Chain Reaction clinically conjunctival conjunctival swabs coronavirus COVID-19 COVID-19 transmission detection Diagnosis eye eyes facilitate hospital Infection male manifestation Manifestations median age nasopharyngeal Nasopharyngeal RT-PCR Nasopharyngeal swab nasopharyngeal swabs Novel coronavirus ocular Ocular manifestation ocular symptoms outbreak pandemic Patient patients patients with SARS-CoV-2 positive positive rate positive result Prevent reverse transcriptase reverse transcriptase-polymerase chain reaction RT-PCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus specimens surpassed Symptom Tear Tear RT-PCR. the median Transmission [DOI] 10.1007/s10792-021-01938-3 PMC 바로가기 [Article Type] Article
Mortality Rates Among Hospitalized Patients With COVID-19 Infection Treated With Tocilizumab and Corticosteroids A Bayesian Reanalysis of a Previous Meta-analysis토실리주맙 및 코르티코스테로이드로 치료받은 COVID-19 감염 입원 환자의 사망률 이전 메타 분석의 베이지안 재분석Meta-Analysis Published on 2022-02-282022-09-12 Journal: JAMA Network Open [Category] MERS, 진단, [키워드] age all-cause mortality Analysis association Bayesian Bayesian methods benefit Can Care clinically concerning Corticosteroid Corticosteroids country COVID-19 credible interval CrI distributions evaluate evaluated finding Future greater Health Organization Hierarchical hospitalized patient hospitalized patients Importance IMV interval Invasive mechanical ventilation magnitude measure men Meta-analysis Mortality mortality risk NIV Noninvasive ventilation objective Odds ratio oxygen oxygen only participant Patient patients with COVID-19 Placebo Point posterior probability Probability randomization Randomized randomized clinical trial Rate receiving reduced Relevance Research Respiratory Support Result risk risk difference robustness setting subgroup subgroups survival the WHO Tocilizumab treated treatment with tocilizumab Trial usual care was performed WHO with COVID-19 World Health Organization [DOI] 10.1001/jamanetworkopen.2022.0548 PMC 바로가기 [Article Type] Meta-Analysis
Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein입원한 COVID-19 환자의 예후 마커: IP-10 및 C-반응성 단백질의 역할Observational Study Published on 2022-02-282022-09-10 Journal: Disease Markers [Category] MERS, 바이오마커, 임상, [키워드] Admission Analysis analyzed Asymptomatic AUC baseline baseline characteristics Biomarker C-reactive protein C-reactive protein (CRP characteristic chemokine clinical condition clinical conditions clinical decision clinically cohort study Concentration Course COVID-19 CRP cytokine death discharge disease disease onset disease severity driving enrolled Evolution expected growth factor heterogeneous Hospital stay Hospitalization Hospitalized hospitalized COVID-19 patients identify immunological independent predictor independent predictors intensive care intensive care unit IP-10 Italy Laboratory Laboratory tests majority Manifestations moderate moderate to severe Multivariate analysis outcome pandemic Patient performed predict prospective cohort study responsible Result ROC role SARS-CoV-2 SARS-CoV-2 positive patient sensitivity serum serum concentrations specificity Stratification trajectory worsening [DOI] 10.1155/2022/3528312 PMC 바로가기 [Article Type] Observational Study
The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial Research Published on 2022-02-282022-10-05 Journal: Nature Medicine [Category] 임상, 진단, [키워드] 95% confidence interval absence Acute heart failure assigned baseline benefit chronic heart failure city clinical clinical benefit Clinical outcome clinically de novo death defined diabetes Diagnosis double-blind trial Ejection fraction Empagliflozin event greater heart failure Hierarchical Hospital admission Hospitalization Hospitalized IMPROVE In-hospital inhibitor initiated median time Patient patients patients hospitalized patients treated Placebo Primary outcome randomization Randomized randomized trial Randomly receive reduce reported risk score Serious Adverse Event stratified the primary endpoint Total treated Treatment Trial ventricular [DOI] 10.1038/s41591-021-01659-1 [Article Type] Research
Biological, Psychological, and Physical Performance Variations in Football Players during the COVID-19 Lockdown: A Prospective Cohort StudyArticle Published on 2022-02-262022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] affected Biological BMI caused change clinically Concentration cortisol COVID-19 COVID-19 lockdown evaluate evaluated Fat mass ferritin Football hematocrit hematological parameters hemoglobin initial Italian lockdown maintain measurement performance performed physical physical performance physiological state plasma power level Prospective prospective cohort study Psychological Psychological stress red blood cells returned Serie A significantly Testosterone Variation Volume [DOI] 10.3390/ijerph19052739 PMC 바로가기 [Article Type] Article
Nonsteroidal anti‐inflammatory drugs in acute viral respiratory tract infections: An updated systematic reviewInvited Review Published on 2022-02-262022-10-29 Journal: Pharmacology Research & Perspectives [Category] Coronavirus, COVID19(2023년), SARS, [키워드] acute respiratory distress syndrome Acute respiratory tract infections Adults adverse event adverse events approach Aspirin children clinically Coronavirus disease 2019 cough database death decrease drug Efficacy and safety estimate Evidence Fever IMPROVE increase in infections management methodology Mortality MOST Nonsteroidal nonsteroidal anti‐inflammatory drugs NSAID NSAIDS Oxygenation Patient randomized clinical trial recommendation reduce reported respiratory tract infection Respiratory tract infections risk of bia robust Sample size searched significantly sore throat study outcome Support systematic review Ventilation viral respiratory Web of Science [DOI] 10.1002/prp2.925 PMC 바로가기 [Article Type] Invited Review
Evaluation of Swab-Seq as a scalable, sensitive assay for community surveillance of SARS-CoV-2 infectionArticle Published on 2022-02-232022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] addition asymptomatic individual clinically collected Community developmental diagnostic Effectiveness effort evaluated expand gold standard independent individual Intensive lab less Modification nasal swab nasopharyngeal Next-generation sequencing noninvasive NP swab polymerase chain protocol qRT-PCR qRT-PCR assay Quantitative repeated resource reverse transcription RNA RNA sequencing Saliva SARS-COV-2 infection SARS-CoV-2 pandemic Scientific community stability subsequent Surveillance Swab symptomatic and asymptomatic utility viral infection [DOI] 10.1038/s41598-022-06901-5 PMC 바로가기 [Article Type] Article