A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNAArticle Published on 2020-03-112022-10-29 Journal: Scientific Reports [Category] Coronavirus, SARS, [키워드] acute respiratory syndrome ATP Biochemistry Characteristics complexes Concentration concentrations coronavirus decrease DNA ENhance exhibited Helicase in viral Microbiology Protein Replication RNA SARS Coronavirus single-stranded translocation [DOI] 10.1038/s41598-020-61432-1 PMC 바로가기 [Article Type] Article
Do Intracerebral Cytokine Responses Explain the Harmful Effects of Dexamethasone in Human Immunodeficiency Virus–associated Cryptococcal Meningitis?뇌내 사이토카인 반응이 인간 면역결핍 바이러스 관련 크립토코커스 수막염에서 덱사메타손의 유해한 영향을 설명합니까?Articles and Commentaries Published on 2019-05-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 95% confidence interval analyzed association baseline Better caused cerebrospinal fluid clearance clinical impact Clinical outcome colony-stimulating factor Concentration concentrations correlation Corticosteroids Cox regression models cryptococcal cryptococcal meningitis CSF cytokine Cytokines Decline Dexamethasone Effect faster following fungal Genotype granulocyte granulocyte-macrophage colony-stimulating factor had no Human Human immunodeficiency virus immunodeficiency Impact inflammatory protein Interaction interferon interferon γ interleukin interleukin 6 investigated leukotriene leukotriene A4 hydrolase LTA4H Macrophage macrophage inflammatory protein 1α mechanism Meningitis monocyte Necrosis outcome participant polymorphism Proinflammatory cytokine promoter region reduced response Result single-nucleotide single-nucleotide polymorphism statistically significant therapy TNF TNF-α Treatment Trial tuberculous tuberculous meningitis Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α Uganda [DOI] 10.1093/cid/ciy725 PMC 바로가기 [Article Type] Articles and Commentaries
Synthetic surfactin analogues have improved anti-PEDV propertiesResearch Article Published on 2019-04-112022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities analogue antiviral activity antiviral drug Antiviral effect Concentration concentrations Critical cytotoxicity derivative determine develop effective evaluated greater groups inhibiting Like linear PEDV Safe surfactin synthetic utility viral membrane virus [DOI] 10.1371/journal.pone.0215227 PMC 바로가기 [Article Type] Research Article
Phylogeographic investigation of 2014 porcine epidemic diarrhea virus (PEDV) transmission in TaiwanResearch Article Published on 2019-03-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] absence affecting clinical sample Cluster Clustering collected concentrations correlation database defined dissemination Epidemic epidemic diarrhea Factor GenBank independent Infection outbreak PEDV Phylogenetic S gene sequence sequence information Spread Strains Taiwan Transmission triggered viral strain virus were used [DOI] 10.1371/journal.pone.0213153 PMC 바로가기 [Article Type] Research Article
Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection키메라 낙타/인간 중쇄 항체는 MERS-CoV 감염으로부터 보호합니다Research Article Published on 2018-08-082022-09-14 Journal: Science Advances [Category] 비임상, 진단, [키워드] Affinity maturation antibodies antibody Antibody Response binding blocked Bone marrow caused chimeric complementarity-determining region concentrations develop domain Dromedary epitope event expression heavy chain high affinity Human humans Intervention MERS coronavirus MERS-CoV MERS-CoV infection mice Middle East mild infection nanobodies outbreak Pathogens PROTECT Receptor binding domain recognize repeated respiratory syndrome coronavirus responses selected serum unique viral spike protein virus virus entry virus-neutralizing antibody [DOI] 10.1126/sciadv.aas9667 PMC 바로가기 [Article Type] Research Article
Effect of selected gastrointestinal parasites and viral agents on fecal S100A12 concentrations in puppies as a potential comparative modelResearch Published on 2018-04-172022-10-28 Journal: Parasites & Vectors [Category] Coronavirus, [키워드] age Alter Analysis animal model assigned association Biomarker Calgranulin C canine CCV clinical utility Cohort collected Comparisons Concentration concentrations coronavirus Correlation analysis diarrhea Effect Enteropathogen evaluate expression fecal Fecal sample French Giardia Infection Inflammation Inflammatory bowel disease intestinal lack not affect parasite pathogen Patient performed Preliminary data radioimmunoassay ranged Result rodents S100A12 selected spot tested Toxocara canis unlikely variables viral infection virus were measured [DOI] 10.1186/s13071-018-2841-5 PMC 바로가기 [Article Type] Research
Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide TypeArticle Published on 2016-11-282022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] 229E acid Activation activities Alter amide amide bond anticancer Antioxidative antioxidative activity Antiviral antiviral activity binding Biological CAD Cell cell line chloride cinnamic acid derivative Compound compounds Concentration concentrations conjugate Conjugates coronavirus cytostatic activity derivative DPPH evaluated Evidence functional group Hela highest inhibitor inhibitory activity LOX MCF-7 morphology motif novel performed primaquine reducing reported selective spacer synthesis Type [DOI] 10.3390/molecules21121629 PMC 바로가기 [Article Type] Article
A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virusClinical Trial Published on 2010-05-112022-10-06 Journal: Proceedings of the National Academy of Sciences of [Category] 진단, [키워드] acquisition Administered Adult Adults Analysis antibody antiviral activity Antiviral effect assays clinical evidence concentrations decrease different double-blind Effectiveness enrolled exhibiting Factors healthy subject Human increase in independent Infected infected children Infection intranasal mechanism mRNA multiple logistic regression murine model nasal nasal washe nucleocapsid number of infected PCR Placebo placebo-controlled study placebo-controlled trial Proinflammatory cytokine proportion Protein protein expression Randomized recipient recipients representing respiratory syncytial virus RNA RSV RSV infection safety profile saline placebo significantly lower siRNA subjects tested therapeutic Therapeutic approach therapy treat uninfected unique viral culture was measured wild-type [DOI] 10.1073/pnas.0912186107 PMC 바로가기 [Article Type] Clinical Trial
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike proteinArticle Published on 2006-04-172022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] affected Anti-viral antiviral activity Asia Atypical cell cytotoxicity Class I viral fusion protein Concentration concentrations coronavirus CoV domain dose-dependent Effect Europe fusion peptide fusion protein glycoprotein heptad repeat hydrophobicity IC50 identify inhibited inhibition inhibitor membrane membrane fusion MHV murine hepatitis virus N-terminus North America peptide Peptide inhibitor Pneumonia provide recent Receptor binding Region regions responsible S2 subunit SARS-CoV severe Severe acute respiratory syndrome-associated coronavirus six-helix bundle tested the S protein viral infectivity viral spike viral spike protein was used white [DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article
Chloroquine is a potent inhibitor of SARS coronavirus infection and spreadResearch Published on 2005-08-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] abrogate acute respiratory syndrome addition angiotensin-converting enzyme 2 Antiviral compounds Antiviral effect appear binding caused Cell Cell culture cellular receptor Chloroquine clinically concentrations coronavirus described effective Elevation endosomal pH function immunofluorescence assay Infection inhibition inhibitor inhibitory effect interfere NO primate cells Prophylactic Result resulting SARS Coronavirus SARS CoV SARS-CoV SARS-CoV infection severe severe acute respiratory syndrome Coronavirus Spread terminal glycosylation therapeutic therapy treated virus virus spread [DOI] 10.1186/1743-422X-2-69 PMC 바로가기 [Article Type] Research