Differences in the tissue tropism to chicken oviduct epithelial cells between avian coronavirus IBV strains QX and B1648 are not related to the sialic acid binding properties of their spike proteinsResearch Published on 2014-06-142022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] analysed Asia avian coronavirus binding Cell characteristic Complete Culture difference disorders Efficiency epithelial cell epithelial cells Europe Genotype IBV infect Infection Infectious Bronchitis Virus kidney Kidney disease Occurrence organs oviduct pathogen pathogenicity permanent cell problem question reason reproductive S1 protein serotypes sialic acid Spike protein strain Strains sugar susceptibility the disease tissue tropism vaccination viruses [DOI] 10.1186/1297-9716-45-67 PMC 바로가기 [Article Type] Research
In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infectionShort Report Published on 2013-12-232022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] acute renal failure Angiotensin-converting-enzyme-2 ARF benefit bronchial epithelial cell bronchial epithelial cells Case report cause Cell cell type cells cellular receptor Characteristics Comparative description Dipeptidyl-peptidase-4 epithelial epithelial cell epithelial cells experiment explain finding histological staining human coronavirus human kidney impairment individual Infected Infection infections infectious kidney kidney infection median time MERS MERS patient MERS-CoV Middle East Middle East respiratory syndrome occurred Patient peer-reviewed potential mechanism produced progeny renal Renal epithelial cells Replication respiratory reveal SARS patients SARS- and MERS-CoV SARS-CoV SD severe staining Symptom systematic review Transmission Treatment Urine [DOI] 10.1186/1743-422X-10-359 PMC 바로가기 [Article Type] Short Report
Infectious Bronchitis Virus Generates Spherules from Zippered Endoplasmic Reticulum MembranesResearch Article Published on 2013-10-222022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome alphaviruses Betacoronavirus candidate Cell cell line cell types cellular cellular membranes characterized cisternae CM complex coronavirus Coronaviruses Culture cultures cytoplasm electron Endoplasmic reticulum epithelial cell Ex vivo generate IBV IBV infection IBV-infected cell in viral induce infected cells Infection Infectious Bronchitis Virus interior invagination lack mammalian cell mean membrane mouse hepatitis virus organ outer membrane pathogen platform positive-sense positive-sense single-stranded RNA related replication complexes Reticulum RNA RNA synthesis RNA virus RNA viruses SARS-CoV sealed spherule spherules Structure thought tissue tomography tracheal Vesicle viral replication Viral RNA virus [DOI] 10.1128/mBio.00801-13 PMC 바로가기 [Article Type] Research Article
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory VirusesResearch Article Published on 2013-07-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] approach both virus component conserved Critical dataset disease pathology effort epithelial cell event Factor feature Gene Host host response human lung identify Infection influence Influenza virus integration Interaction Intervention involved lung epithelial Metrics network Pandemics pathogen pathogenicity predict predicted proteome public health threat Regression model regulator Regulatory related respiratory respiratory virus SARS-CoV severe therapeutic target transcriptome dataset utility viral pathogenesis virus [DOI] 10.1371/journal.pone.0069374 PMC 바로가기 [Article Type] Research Article
Isolation and genetic characterization of human coronavirus NL63 in primary human renal proximal tubular epithelial cells obtained from a commercial supplier, and confirmation of its replication in two different types of human primary kidney cellsResearch Published on 2013-06-272022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Cell Cell culture cell lines cells CMV coronavirus cytomegalovirus cytoplasmic detected Deterioration determine different DNA epithelial cell Genetic HCoV-NL63 herpesvirus HHV-6B Human human kidney immunofluorescence assay induce infectious agents initiated Isolation kidney Laboratory Microscopy NL63 observation PCR proximal renal replicate Replication Result RPTEC RT-PCR Sequencing simian virus SV40 virus [DOI] 10.1186/1743-422X-10-213 PMC 바로가기 [Article Type] Research
Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory virusesArticle Published on 2013-04-292022-11-01 Journal: Virus research [Category] Coronavirus, 신종인플루엔자, [키워드] activating alveolar cell alveolar epithelial cell alveolar epithelial cells ATII Cell cell type cells contribute coronavirus correlated Critical Culture cytokine cytokine expression cytokine response Cytokines determine determined different disease severity epithelial cell exhibited Express expression Factor H1N1 Host IAV identify IL-1β immune responses in vitro model in vivo increased expression Infected Infection influenza A influenza A virus lung Lungs maintain Mouse-adapted SARS-coronavirus mouse-adapted SARS-CoV mRNA murine murine coronavirus murine model Pathogenesis pathology phenotype quantified respiratory viral infection respiratory virus respiratory viruses response robust SARS-CoV severe spread to susceptibility susceptible target type I Type I pneumocyte Type II pneumocyte v2163 viral infection viral infections viral pathogenesis virus viruses while [DOI] 10.1016/j.virusres.2013.04.008 PMC 바로가기 [Article Type] Article
Pathogenetic mechanisms of severe acute respiratory syndromeArticle Published on 2007-09-072022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] acute respiratory disease acute respiratory syndrome affected angiotensin-converting enzyme 2 autopsy study Brain caused cell type cellular and molecular clinical manifestation contribute Diagnosis digestive tract Direct disease dysfunction enterocytes epithelial cell expressing hypoxia immune cells immune responses immune system implication include Infected Infection Injury kidneys liver lung mechanism morbidity and mortality neurons organ Other Pathogenesis pathological finding pathology pneumocyte primary target cell receptor renal SARS SARS-CoV severe target cell the disease therapy thyroid gland virus while [DOI] 10.1016/j.virusres.2007.01.022 PMC 바로가기 [Article Type] Article
SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epitheliumArticle Published on 2007-04-232022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] addition airway airway epithelial cells airway epithelium Antisera apical surface Atypical Calu-3 Calu-3 cell Cell cells cellular Characteristics ciliated ciliated cell consequence coronavirus coronavirus pathogenesis Coronavirus replication Culture cultures detected develop did not reduce dry cough efficient enzyme Epidemics epithelial epithelial cell epithelial cell line Experimental result feature Fever fluorescent Frame GFP hACE2 HAE Human human airway epithelia human airway epithelial Human airway epithelium human lung human pathogen in vitro in vitro model in vivo Infection inoculated insertion late stage log Lower respiratory tract lung lung epithelial mechanism Morphological new strain onset of symptoms ORF Pathogenesis pathology physiological Pneumonia Post-infection primary cell progeny virion Protein provide reached receptor reduced replicate replicated Replication reported reservoir respiratory virus resulting SARS Coronavirus SARS-CoV SARS-CoV GFP SARS-CoV infection Support susceptible target tight junction Trachea Vero E6 viral infection viral replication viral titer virus wild type zoonotic [DOI] 10.1016/j.virusres.2007.03.013 PMC 바로가기 [Article Type] Article