3-Indoleacetonitrile Is Highly Effective in Treating Influenza A Virus Infection In Vitro and In VivoArticle Published on 2021-07-232023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] 3-indoleacetonitrile Antiviral indole derivatives indole-3-carboxaldehyde influenza A virus [DOI] 10.3390/v13081433 PMC 바로가기 [Article Type] Article
High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitroArticle Published on 2021-07-222022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] absence ACE2 air–liquid interface airway airway epithelial cell animal models Antiviral antiviral agent biomedical engineering Camostat mesylate can be used Combination coronavirus Coronavirus infections Coronaviruses COVID-19 Culture Donor effective Efficacy evaluate expression HCoV-NL63 host cell Human human primary cells immortalized cell line in vitro Infection Influenza influenza A virus inhibitor National other respiratory virus Pandemics platform Population Predictive priming protease TMPRSS2 public health robust SARS-CoV-2 small molecule Spike protein strain therapeutic efficacy tissue viral infection [DOI] 10.1038/s41598-021-94095-7 PMC 바로가기 [Article Type] Article
Critical role of microRNAs in host and influenza A (H1N1) virus interactionsReview Published on 2021-07-152023-06-23 Journal: Life sciences [Category] 신종인플루엔자, [키워드] H1N1 virus influenza A virus microRNA non-coding RNA [DOI] 10.1016/j.lfs.2021.119484 [Article Type] Review
Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity선천 면역 자극을 통한 시험관 내 SARS-CoV-2 복제에 대한 인플루엔자 A 바이러스 결함 간섭 입자의 항바이러스 활성Communication Published on 2021-07-112022-09-11 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] abrogation activity acute respiratory syndrome acute respiratory syndrome coronavirus Administered Antiviral antiviral activity antiviral agent Antiviral treatment applicability approved Cell Cell culture Co-infection Complete conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 defective interfering particles dependent on DI244 DIP disease effective Efficacy experiment human lung cells IAV Immune escape in vitro Influenza influenza A influenza A virus inhibitory effect Innate Innate immunity interferon JAK/STAT janus Janus kinase leads OP7 pandemic Particle Replication respiratory Respiratory virus infections SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT Stimulation Transcription Treatment treatment of COVID-19 Vaccine vaccine availability variant variants of SARS-CoV-2 virus virus infections [DOI] 10.3390/cells10071756 PMC 바로가기 [Article Type] Communication
Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus InfectionSARS-COV-2 및 인플루엔자 -A 바이러스 감염에 대한 기본 아미노산 및 이들의 유도체의 영향Article Published on 2021-07-042022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] acid amino acids antiviral therapy arginine basic boost both virus both viruses broad-spectrum antivirals caused Compound COVID-19 derivative Disease prevention Effect Endosomal acidification ester Food Intake implicated in vitro Infection Influenza influenza A influenza A virus lysine mechanism of action paradigm Prophylactic reduction regimen Replication SARS-CoV-2 therapeutic these viruses virus virus infection viruses [DOI] 10.3390/v13071301 PMC 바로가기 [Article Type] Article
Multiplex Real-Time Reverse Transcription PCR for Influenza A Virus, Influenza B Virus, and Severe Acute Respiratory Syndrome Coronavirus 2인플루엔자 A 바이러스, 인플루엔자 B 바이러스 및 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 다중 실시간 역전사 PCRResearch Published on 2021-07-012022-09-10 Journal: Emerging Infectious Diseases [Category] 유전자 메커니즘, 치료기술, [키워드] 2019 novel coronavirus disease acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus cause caused coronavirus coronavirus 2 coronavirus disease Coronaviruses COVID-19 Culture detect diagnostic differentiation drug Emergency use authorization Flu SC2 Multiplex food identify in vitro increase infectious dose Influenza influenza A influenza A virus influenza B influenza B virus Influenza virus influenza viruses multiplex Multiplex assay outbreak pandemic pathogen Pathogens PCR reaction real-time RT-PCR resources respiratory respiratory infections respiratory virus RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Surveillance Symptom tissue tissue culture US Food and Drug Administration virus viruses zoonoses [DOI] 10.3201/eid2707.210462 PMC 바로가기 [Article Type] Research
Serological Evidence for Influenza A Viruses Among Domestic Dogs and Cats in Kyiv, UkraineReview Article Published on 2021-07-012023-06-23 Journal: Vector Borne and Zoonotic Diseases [Category] 신종인플루엔자, [키워드] antibodies cat dog ELISA influenza A virus Ukraine [DOI] 10.1089/vbz.2020.2746 PMC 바로가기 [Article Type] Review Article
Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural ModelsResearch Article Published on 2021-06-232022-10-30 Journal: mSphere [Category] COVID-19, MERS, SARS, [키워드] accumulating ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 associated immune response Brain cell tropism cell type cells Central nervous system cerebrospinal fluid CNS contribute coronavirus COVID-19 COVID-19 patients Culture cultures disease Evidence expression H5N1 H5N1 influenza A H5N1 virus highly pathogenic hiPSC neurons Human Hypothesis IL-8 induced infect Infection influenza A virus Influenza virus interferon Invasion investigated Kinetics local immune response Model Neural Neurological complication Neurological complications Neuron neurons neurotropic neurotropism NPR1 olfactory Pathogenesis pluripotent stem cell protease replicated replication kinetics response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication serine 2 Spread STEM subsequent Support TMPRSS2 transmembrane triggered triggering tropism type III interferon variety virus virus replication virus spread [DOI] 10.1128/mSphere.00270-21 PMC 바로가기 [Article Type] Research Article
Genome Features and In Vitro Activity against Influenza A and SARS-CoV-2 Viruses of Six Probiotic StrainsResearch Article Published on 2021-06-182022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, Fulltext, MERS, SARS, 신종인플루엔자, [키워드] activity Antibiotic resistance Antibiotics antiviral activity Bacterial Bifidobacterium Bifidobacterium longum biochemical caused cells Complete demonstrated determinant determine disease explained Genome H1N1 Human Illumina Inc infect influenza A influenza A virus Influenza virus intestine lactobacillus MDCK cells MiSeq molecular nonpathogenic plasmids platform Probiotic probiotic bacteria resistance respiratory virus Result Safe SARS-CoV-2 SARS-CoV-2 virus strain SARS-CoV-2 viruses strain Strains the SARS-CoV-2 virus was performed were used Whole genome sequencing [DOI] 10.1155/2021/6662027 PMC 바로가기 [Article Type] Research Article
Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity바이러스 유사 입자 백신에 cGAMP를 포함하면 면역원성이 향상됩니다.Article Published on 2021-06-182022-09-12 Journal: EMBO Reports [Category] MERS, SARS, 진단, [키워드] accompanied activate Administered Antibody titre antibody titres Antigen antigens CD4 CD8 T‐cell Cell cells cGAMP cyclic doses ENhance follicular Gag glycoprotein G Haemagglutinin immunology immunostimulatory Inclusion increase induce influenza A virus Methods & Resources mice Microbiology, Virology & Host Pathogen Interaction neutralising antibody Particle Particles platform produced Protein reduced responses SARS‐CoV‐2 spike SARS‐CoV‐2 titre type I interferon vaccination Vaccine vector vesicular stomatitis virus viral vaccine vector virus Virus neutralisation virus particle VLP VLPs [DOI] 10.15252/embr.202152447 PMC 바로가기 [Article Type] Article