interferon – Page 26 – Communicable Diseases Research

Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals

코로나바이러스 질병 2019 메신저 RNA 백신 면역억제된 개인의 면역원성

Article

Published on 2022-04-012022-09-11
Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] 19 vaccine 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody Antibody Response Antibody responses binding CD4 CD8 T-cell coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 mRNA Vaccination cross-reactivity function Immunocompromised immunocompromised individuals immunogenicity immunosuppressive increased mortality individual individuals Infection interferon interferon-γ lead messenger Messenger RNA mRNA mRNA vaccination mRNA vaccine Neutralizing reduce reduced regimen respiratory response RNA SARS SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus T cells therapy These data vaccine immunogenicity Viral viral clearance Viral variants
[DOI] 10.1093/infdis/jiab569 PMC 바로가기 [Article Type] Article

Tracing the SARS-CoV-2 infection on the ocular surface: Overview and preliminary corneoscleral transcriptome sequencing

안구 표면의 SARS-CoV-2 감염 추적: 개요 및 예비 각막 공막 전사체 시퀀싱

Article

Published on 2022-04-012022-09-11
Journal: Experimental eye research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] absence ADAMTS4 Analysis AQP5 associable caused Cluster Clusters component Cornea Corneal Corneoscleral ring COVID-19 CTRL Cytokines DEGs differentially expressed gene Differentially expressed genes Donor down-regulated gene down-regulated genes enrichment analysis Eye bank gene expression profile Gene ontology Genes genomic genomic RNA GO analysis GO term IL6 Illumina inactive indicated infected individual infected individuals Infection interferon interferon pathway ISG ISG15 ISGs Local Manifestations MMP1 modulation molecular mechanism molecular mechanisms ocular Ocular surface pathway PCA PCA analysis performed Perturbation positive Post-mortem principal Principal component principal component analysis proinflammatory cytokines Protective qRT-PCR RNA RNA-sequencing RSAD2 SARS-CoV-2 SARS-CoV-2 RNA several gene several genes Support tears the interferon the SARS-CoV-2 tissue tracing transcriptional Transcriptome transcriptome analysis transcriptome sequencing virus was performed
[DOI] 10.1016/j.exer.2022.108975 PMC 바로가기 [Article Type] Article

Immunogenicity and safety after the third dose of BNT162b2 anti-SARS-CoV-2 vaccine in patients with solid tumors on active treatment: a prospective cohort study

활성 치료 중인 고형 종양 환자에서 BNT162b2 항-SARS-CoV-2 백신 3차 접종 후 면역원성과 안전성: 전향적 코호트 연구

Article

Published on 2022-04-012022-09-11
Journal: ESMO open [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] active treatment acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration anti-SARS-CoV-2 antibody baseline BNT162b2 BNT162b2 anti-SARS-CoV-2 vaccine booster booster dose Cancer cancer patient Cancer patients cell-mediated immune cell-mediated immune response Concentration consecutive patient coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 infection Delta dose effective Efficacy enrolled evaluated Gamma humoral IgG IgG antibody immunogenicity Immunoglobulin Immunoglobulin G interferon interferon gamma interferon-γ interquartile range IQR median Messenger RNA naïve naïve subject naïve subjects neutralization Neutralizing neutralizing antibody of BNT162b2 omicron Patient patients Preliminary data primary endpoint prospective cohort study quantified reached recruited Release respiratory SARS-CoV-2 SARS-CoV-2 vaccine serum severe acute respiratory syndrome Coronavirus significantly higher solid cancer solid tumor subject subjects the median the SARS-CoV-2 third dose Treatment Trigger Vaccine variant variants variants of concern VOCs were used whole blood sample wild-type strain
[DOI] 10.1016/j.esmoop.2022.100458 PMC 바로가기 [Article Type] Article

Bacterial/fungal infection in hospitalized patients with COVID-19 in a tertiary hospital in the Community of Castilla y León, Spain

스페인 카스티야 이 레온 지역 3차 병원에 입원한 COVID-19 환자의 박테리아/진균 감염

Observational Study

Published on 2022-04-012022-09-11
Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] COVID19(2023년), SARS, 임상, 치료기술,

[키워드] Acinetobacter Acinetobacter baumannii Acinetobacter baumanniia Admission analyses Bacteremia Brote Coinfección Coinfection Comorbidities contribute contributed COVID-19 COVID-19 patients demographic determine diagnosed elevated English Factor hospital hospitalized patient hospitalized patients ICU ICU patient ICU Patients incidence increase Increases Infection intensive care unit interferon IQR Leukocytosis majority male median age men Mortality MOST multidrug-resistant multivariate logistic regression observational study outbreak pacientes hospitalizado pathogen Pathogens Patient patients Predictive predictor profile profiles pulmonary aspergillosis respiratory infections SARS-CoV-2 SARS-CoV-2 pneumonia Sobreinfección Spain Spanish Staphylococcus aureus Streptococcus pneumoniae superinfection Superinfections Tocilizumab urinary viral respiratory infection viral respiratory infections with COVID-19
[DOI] 10.1016/j.eimce.2022.02.002 PMC 바로가기 [Article Type] Observational Study

Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients

조합 분석은 경증 COVID-19 환자에서 나중에 항바이러스 면역을 예측하는 고도로 조정된 초기 단계 면역 반응을 보여줍니다

Article

Published on 2022-03-292022-09-11
Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료제,

[키워드] Analysis antibody antibody levels Antibody Response antibody-secreting cell antibody-secreting cells antiviral immunity Arm Asymptomatic CD4 CD8 T cells cellular Cohort combinatorial analysis controls COVID-19 CXCL10 cytokine cytokine response dendritic cell Diagnosis dominant early-stage response expression feature Frequency functional hospitalized patient hospitalized patients immune immune cells immune reaction immune response immune responses immunology immunopathology Inclusion innate immune cell Innate immune cells interferon IP10 marker Mild mild COVID-19 patient mild COVID-19 patients mild patient mild patients non-hospitalized observé Patient PCR predict predict antibody levels Predictive remained response reveal SARS-CoV-2 severe COVID-19 systematic analysis systems immunology T cell T cells trajectory transient cytokine response. while
[DOI] 10.1016/j.xcrm.2022.100600 PMC 바로가기 [Article Type] Article

Translational Control of COVID-19 and Its Therapeutic Implication

Review

Published on 2022-03-292023-06-15
Journal: Frontiers in Immunology [Category] MERS, SARS,

[키워드] COVID-19 inhibitor interferon SARS-CoV-2 translation
[DOI] 10.3389/fimmu.2022.857490 PMC 바로가기 [Article Type] Review

A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity

Article

Published on 2022-03-282023-06-14
Journal: Emerging Microbes & Infections [Category] Fulltext, 신종인플루엔자,

[키워드] alveolar macrophage Influenza interferon Prophylactic respiratory syncytial virus
[DOI] 10.1080/22221751.2022.2050951 PMC 바로가기

Obesity and Leptin Resistance in the Regulation of the Type I Interferon Early Response and the Increased Risk for Severe COVID-19

Review

Published on 2022-03-262023-06-15
Journal: Nutrients [Category] MERS, SARS,

[키워드] COVID-19 interferon Leptin metaflammation obesity SARS-CoV-2 SOCS
[DOI] 10.3390/nu14071388 PMC 바로가기 [Article Type] Review

STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

STING 효능제 diABZI, PANoptosis 및 DNA 매개 급성 호흡 곤란 증후군(ARDS) 유도

Article

Published on 2022-03-252022-09-11
Journal: Cell Death & Disease [Category] SARS, 치료법,

[키워드] Activation acute lung inflammation acute respiratory distress AIM2 airway amplification amplifying Apoptosis apoptosis induction ARDS CASP8 caspase-3 cell death cGAS cleavage complex contribute Cytokines cytoplasm DDX41 dinucleotide Disruption DNA DNase I double-stranded dsDNA ENhance epithelial extracellular DNA followed by gasdermin D IFN IFN-I IFNAR1 IL-1β IL-6 immune response immune responses induce Infection inflammasomes Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response interferon IRF3 low dose lung Lung inflammation mice MLKL necroptosis NET NETosis neutrophilic neutrophilic response NF-kB NF-kB pathway NLRP3 NLRP3 inflammasome nucleotide pathway Phosphorylation priming pro-inflammatory cytokine pro-inflammatory cytokines pyroptosis receptor RIPK3 SARS-COV-2 infection severe ARDS signaling pathway silica smoke stimulator STING subsequent suggested syndrome TBK1 therapeutic strategy TLR9 TNFR1 TNFα Treatment triggered Tumor tumors Type I IFN type I IFN response type I interferon upregulation viral infection ZBP1
[DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article

Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus

Article

Published on 2022-03-232023-06-14
Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자,

[키워드] Influenza virus interferon plasmacyotid DCs secretome and transcriptome analysis single cell RNA seq.
[DOI] 10.3389/fimmu.2022.814627 PMC 바로가기