Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipelineAnti-SARS-CoV-2 중화 단일클론항체: 임상 파이프라인Article Published on 2020-01-012022-09-11 Journal: mAbs [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, [키워드] anti-SARS-CoV-2 antibody bamlanivimab BGB-DXP593 candidate clinical trials Convalescent plasma therapy COVID-19 COVID-19 pandemic CT-P59 disease Ebolavirus Efficacy focus GSK4182136 LY-CoV016 LY-CoV555 mAb mAb cocktails mAbs mechanism mechanism of action monoclonal monoclonal antibody monoclonal antibody. Neutralizing ongoing trial ongoing trials phase Phase 2 Pneumonia REGN-CoV2 Research research and development respiratory syncytial virus SARS-CoV-2 therapy VIR-7831 Viral viral infections virus pneumonia while [DOI] 10.1080/19420862.2020.1854149 PMC 바로가기 [Article Type] Article
The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signalsCspC pseudoprotease는 여러 환경 신호에 대한 응답으로 Clostridioides difficile 포자의 발아를 조절합니다Research Article Published on 2019-07-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Alter Amino acid Bacteria bile acid bile acids calcium Clostridioide Clostridioides conserved Critical crystal structure detect dormant exhibited function germination Gut hypo induce Infection initiate involved lack mammalian mechanism mechanism of action Mutation nosocomial Organisms pathogen physically question raise receptor regulate residue sensitivity Signaling small molecule Small molecules spore thought transmembrane unique variant while [DOI] 10.1371/journal.pgen.1008224 PMC 바로가기 [Article Type] Research Article
Development of Small-Molecule MERS-CoV InhibitorsReview Published on 2018-12-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] development inhibitor mechanism of action MERS-CoV MERS-CoV infection Middle East Pandemics Prevent public health Research respiratory syndrome coronavirus small-molecule inhibitor Stage treat [DOI] 10.3390/v10120721 PMC 바로가기 [Article Type] Review
Host-directed therapies for bacterial and viral infectionsArticle Published on 2017-09-222023-08-30 Journal: Nature Reviews Drug Discovery [Category] E형 간염, [키워드] Diseases Drug development Drug discovery and development drug therapy Infectious diseases mechanism of action Tuberculosis Viral hepatitis viral infection [DOI] 10.1038/nrd.2017.162 PMC 바로가기 [Article Type] Article
Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor초파리의 기능성 남성 액세서리 땀샘과 생식력에는 새로운 엑디손 수용체가 필요합니다Research Article Published on 2017-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (Nuclear Receptors) analyzed Behavior Biodiversity carried cause cell death cells Critical Depletion dominant negative downstream Drosophila Drosophila melanogaster dying cells Ecdysone examined females Fertility forms Health hormone hormone receptor hormone receptors include independent insect Insects isoform male male fertility male reproductive system males management mechanism of action molecular Nuclear receptors pest control Physiology Protein protein synthesis Proteins receptor receptors regulated Regulation reproduction reproductive reproductive system secretory tissue Seminal fluid sterility tissue transcription factor transcription factors transfer [DOI] 10.1371/journal.pgen.1006788 PMC 바로가기 [Article Type] Research Article
Naturally derived anti-hepatitis B virus agents and their mechanism of actionReview Published on 2016-01-072023-06-18 Journal: World journal of gastroenterology [Category] B형 간염, [키워드] drug target Hepatitis B virus mechanism of action natural product structure. [DOI] 10.3748/wjg.v22.i1.188 PMC 바로가기 [Article Type] Review
Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replicationResearch Article Published on 2014-01-162022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Nigella sativa Rhodiola rosea Sambucus nigra Anti-viral drugs bronchitis Cell compounds Concentration coronavirus Cytopathic effect cytotoxicity derivative determined different Effect electron microscopy highest IBV infected cell Infection Infectious Bronchitis Virus inhibit magnitude mechanism of action membrane MOI multiplicity of infection Nigella Sativa non-infectious other coronavirus pathogenic plant Plaque assay Prevent protocol quantified reduced Replication Result Rhodiola Safe Sambucus solvent staining suggested supernatant tested tissue transmission electron microscopy treat treated Treatment trypan blue staining vaccination Vero Cell vesicles viral titer virion virus virus inhibition virus titer viruses [DOI] 10.1186/1746-6148-10-24 PMC 바로가기 [Article Type] Research Article
Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection작은 분자에 의한 숙주 면역 방어의 자극은 세균 감염으로부터 C. elegans를 보호합니다Research Article Published on 2012-06-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect analysis antibiotic Antibiotics ATF-7 Author Bacterial Bacterial infection Bacterial infections bacterial pathogen Bacterial pathogens Caenorhabditis elegan Caenorhabditis elegans cellular processe cellular processes Compound conserved effector molecule Efficacy elegan expression Gene Genes growth Host immune response host immunity identify immune immune regulators immunostimulatory Infection Interaction low molecular weight mechanism mechanism of action mode molecule molecules mutants nematode offer Pathogens pathway promote PROTECT Pseudomonas aeruginosa required small molecule Small molecules stimulate Stimulation tested therapy These data Transcription transcription factor Transcriptome Treatment variety [DOI] 10.1371/journal.pgen.1002733 PMC 바로가기 [Article Type] Research Article
A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E ProteinResearch Article Published on 2012-05-032022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activities adopted affected Antiviral strategies Author coronavirus correlated defined different disrupt disrupting domain E protein examined found function functions Golgi Host hydrophobic IBV identify Impact implicated in vitro independent infected cells Infection infectious Infectious Bronchitis Virus Infectious virus less mapped mechanism of action membrane membrane protein mutant occur Particle Particles predicted promote Protein reported required residue secretory pathway Substitution thought Topology transmembrane virion assembly virus virus [DOI] 10.1371/journal.ppat.1002674 PMC 바로가기 [Article Type] Research Article