Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individualsBNT162b2-mRNA 백신 접종 개인에서 우려되는 SARS-CoV-2 변이체의 돌파율 증가에 대한 증거Article Published on 2021-06-142022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 변종, [키워드] apprehension B.1.1.7 B.1.351 B.1.351 variant BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine BNT162b2 mRNA vaccine caused cohort study Complete controls COVID-19 vaccine distribution dose effective Effectiveness evade Evidence evidence of first dose genomic sequencing individual Infection laboratory assays mRNA nasopharyngeal swabs neutralization of BNT162b2 performed phylogenetics positive Prevent proportion reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant second dose sera service single dose Spread tested vaccination Vaccine vaccinee vaccinees variants variants of concern Viral viral genome sequence viral infection Viral variants VoC VOCs [DOI] 10.1038/s41591-021-01413-7 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 using qRT-PCR in saliva obtained from asymptomatic or mild COVID-19 patients, comparative analysis with matched nasopharyngeal samples무증상 또는 가벼운 COVID-19 환자로부터 얻은 타액에서 QRT-PCR을 사용하여 SARS-COV-2의 검출, 일치하는 비 인두 샘플과의 비교 분석Comparative Study Published on 2021-06-102022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis Asymptomatic asymptomatic or mild patients coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak Cruise ship detection Diagnosis include Infection interval intervals Japan late phase mild COVID-19 patients mild patient Nagasaki nasopharyngeal sample Nasopharyngeal swab nasopharyngeal swabs objective occurred positive rate qRT-PCR quantified Quantitative Quantitative RT-PCR respiratory Result RT-PCR Saliva saliva specimen saliva specimens sampling SARS-CoV-2 SARS-CoV-2 detection SEM Severe acute respiratory syndrome Viral Viral load [DOI] 10.1371/journal.pone.0252964 PMC 바로가기 [Article Type] Comparative Study
A Comprehensive Molecular Epidemiological Analysis of SARS-CoV-2 Infection in Cyprus from April 2020 to January 2021: Evidence of a Highly Polyphyletic and Evolving Epidemic2020 년 4 월부터 2021 년 1 월까지 키프로스에서 SARS-COV-2 감염에 대한 포괄적 인 분자 역학 분석 : 고도로 다발성 및 진화 전염병의 증거Article Published on 2021-06-092022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] A222V A570D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted affected analyses Analysis antibody Asia B.1 B.1.1.7 B.1.177 Brazil characterized clinical sample clinical samples Comprehensive concern coronavirus COVID-19 Cyprus Czech Republic D1118H D614G Denmark diagnostic diagnostic testing Epidemic epidemiological Europe European evidence of Genetic genetic analysis Germany global public health Health crisis hospitalized patients immune evasion indicated Infection initial island Italy L18F limit Lineage lineages lockdown majority measure molecular Molecular epidemiology Mutation N439K N501Y nasopharyngeal swabs outbreak P681H performed phylodynamic Phylogenetic phylogenetic analyses Phylogenetic analysis phylogeographic analysis prevalent lineage respiratory resulting retrospective S protein S982A SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 isolates severe acute respiratory syndrome Coronavirus Slovenia Spread study period Switzerland the S protein the SARS-CoV-2 Transmissibility transmissibility of SARS-CoV-2 United Kingdom USA variant virus VoC [DOI] 10.3390/v13061098 PMC 바로가기 [Article Type] Article
Assessment of the Diagnostic Ability of Four Detection Methods Using Three Sample Types of COVID-19 Patients3가지 샘플 유형의 COVID-19 환자를 사용한 4가지 탐지 방법의 진단 능력 평가Comparative Study Published on 2021-06-072022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] Ability Accuracy addition amplification assessment best caused coronavirus disease Coronavirus disease 2019 cough COVID-19 COVID-19 patient COVID-19 patients dd-RT-PCR detection Diagnosis evaluate evaluated exhibited followed by gold gold standard highest hospitalized COVID-19 patients IMPROVE IQR Laboratory lead Misdiagnosis Nasopharyngeal swab nasopharyngeal swabs NPs nucleic acid Nucleic acid detection ORF1 ORF1ab oropharyngeal swab pandemic Patient polymerase chain reaction polymerase chain reactions positive Prevention and control reached Result reverse transcription RT-PCR RT-RAA Saliva Sample sample type SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 nucleic acid significantly lower tested Type Viral Viral load [DOI] 10.3389/fcimb.2021.685640 PMC 바로가기 [Article Type] Comparative Study
Clinical Differences between COVID-19 and a COVID-Like SyndromeBrief Report Published on 2021-06-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] affected Atypical atypical COVID-19 clinical presentation Characteristics characterized clinical Clinical management clinical presentation cohort of patient COVID-19 COVID-19 disease COVID-like syndrome described detectable difference General population greater hospital Hospitalized Infection lung failure nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs NPs pandemic Patient physician Pneumonia positive repeated reported risk of infection SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 viral RNA serological Swab test Symptom syndrome tested virus [DOI] 10.3390/jcm10112519 PMC 바로가기 [Article Type] Brief Report
SARS-CoV-2 complete genome sequencing from the Italian Campania region using a highly automated next generation sequencing system고도로 자동화된 차세대 시퀀싱 시스템을 사용하여 이탈리아 캄파니아 지역에서 SARS-CoV-2 완전한 게놈 시퀀싱Research Published on 2021-06-052022-09-10 Journal: Journal of Translational Medicine [Category] MERS, SARS, 변종, [키워드] analysed automated B.1 B.1.1 Campania Campania region Complete contagiousness copy number coronavirus coronavirus genomes COVID-19 facilitate faster Genome genome sequence Genome sequencing genomic GISAID database greater Ion Ion AmpliSeq SARS-CoV-2 Research Panel IQ-TREE Italian lineages N genes Nasopharyngeal swab nasopharyngeal swabs next generation sequencing Non-synonymous non-synonymous variant nucleotide ORF1 ORF1ab ORF3a pandemic Panel positive protocol Rapid reconstruction reference strain Region reported Result RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 sequencing sequenced Sequencing Standardization submitted substitutions supplementary material Surveillance synonymous tested the SARS-CoV-2 genome untranslated regions UTRs Vaccines variant variants Viral viral genome Viral load viral RNA quantification viral titer virus was performed Wuhan-Hu-1 [DOI] 10.1186/s12967-021-02912-4 PMC 바로가기 [Article Type] Research
Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19Research Published on 2021-05-252022-10-29 Journal: JAMA Network Open [Category] COVID-19, SARS, [키워드] 95% CI Admission age association C-reactive protein CD14 CD16 cellular signaling pathways circulating classical clinical trial cohort study collected Concentration concentrations conducted consecutive patient contribute COVID-19 COVID-19 illness diagnosed disease disease severity enrichment analysis estradiol exposure finding growth factor hepatocyte growth factor hormone hormone concentration Hospitalization Hospitalized Hypothesis IGF-1 Importance Inflammation Inflammatory cytokine intensive care interferon male measure median men monocyte mononuclear cell nasopharyngeal swabs objective outcome participant pathophysiologic Patient patients with COVID-19 Point predisposition prospective cohort study Protein receptor regulated Relevance remained required Result risk factor RNA sequencing serum serum sample setting severe COVID-19 severe COVID-19 illness severity Sex sex hormone Signaling signaling pathway single-center Testosterone the patient Treatment upregulated upregulation was performed were measured with COVID-19 women [DOI] 10.1001/jamanetworkopen.2021.11398 PMC 바로가기 [Article Type] Research
The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age사이토카인과 호중구 유전자 네트워크 사이의 관계는 SARS-CoV-2 감염 환자를 성별과 연령으로 구분합니다Research Article Published on 2021-05-242022-09-10 Journal: JCI Insight [Category] SARS, 유전자 메커니즘, [키워드] age approach association chemokine chemokines correlated COVID-19 CXCL8 CXCR1 CXCR2 cytokine Cytokine storm Cytokines data set data sets DBNL DEGs differentially expressed gene Differentially expressed genes downregulated Elderly patient elderly patients exhibited Fatality rate female female patient Female patients gene network Genes IL-1 IL-1 β immune modulation increasingly infected with SARS-CoV-2 Inflammation Inflammatory ITGAM leukocytes male modulation Molecular genetics Nasopharyngeal swab nasopharyngeal swabs neutrophil neutrophil activation Neutrophils outcome pathological role pathway Patient patients patients with SARS-CoV-2 Peripheral blood peripheral blood leukocyte peripheral blood leukocytes Protective provide receptor reduced S100A9 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2–infected patient Sex subjects transcriptional transcriptional level upregulated [DOI] 10.1172/jci.insight.147535 PMC 바로가기 [Article Type] Research Article
Comparative evaluation of six nucleic acid amplification kits for SARS-CoV-2 RNA detectionSARS-CoV-2 RNA 검출을 위한 6가지 핵산 증폭 키트의 비교 평가Comparative Study Published on 2021-05-222022-09-01 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] SARS, 진단, 치료기술, [키워드] Accuracy applied automated Chain Reaction clinical laboratories clinical manifestation clinical sample clinical samples clinically coefficient coefficients Comparative coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak COVID-19 pandemic COVID-19 patients Cross-priming isothermal amplification (CPA) diagnose diagnostic difference drug evaluate evaluated FIVE Health crisis isothermal isothermal amplification less molecular nasal swab nasal swabs Nasopharyngeal swab nasopharyngeal swabs nucleic acid nucleic acid amplification Nucleic acid detection operator outbreak performed point-of-care polymerase chain reaction Predictive predictive values public health crisis Real-time reverse transcriptase PCR (RT-qPCR) reference standard reproducibility Result reverse transcriptase RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity specificity specimen sputum statistically significant testing protocol testing protocols the SARS-CoV-2 throat swab throat swabs Vaccine Variation virus detection was determined were assessed were used [DOI] 10.1186/s12941-021-00443-w PMC 바로가기 [Article Type] Comparative Study
One-Year Update on Salivary Diagnostic of COVID-19COVID-19의 타액 진단에 대한 1년 업데이트Review Published on 2021-05-212022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, [키워드] Biomarker clinical trial close contact contact with Contamination coronavirus disease Coronavirus disease 2019 COVID-19 Critical detect Diagnosis diagnostic diagnostic test False negative false negative results frontline healthcare workers gold gold standard Health health problem healthcare Healthcare professional healthcare professionals implementation infected patient infected patients invasive limitation nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Non-invasive Patient platform professional PROTECT risk Safe Saliva salivary salivary diagnostic SARS-CoV-2 SARS-CoV-2 RNA specimen Support tested [DOI] 10.3389/fpubh.2021.589564 PMC 바로가기 [Article Type] Review