not differ – Page 26 – Communicable Diseases Research

Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients

호흡기에서 SARS-CoV-2 배출의 역학은 COVID-19 환자의 질병 중증도에 따라 다릅니다

Article

Published on 2021-07-202022-09-11
Journal: The European Respiratory Journal [Category] Fulltext, SARS, 치료기술,

Prevalence and Predictors of Prolonged Cognitive and Psychological Symptoms Following COVID-19 in the United States

Neuroscience

Published on 2021-07-192022-10-31
Journal: Frontiers in Aging Neuroscience [Category] COVID-19,

[키워드] 95% CI activity adjusted age Analysis Anxiety average coded cognitive Community Community Dwellers conducted Contact covariate covariates COVID-19 COVID-19 negative COVID-19 positive subjects COVID-19 symptoms demographics Depression diagnosed Diagnosis disorder dysfunction eligible participant Factor fatigue female greater group Hispanic identify initial Laboratory testing logistic regression model Long-hauler male measure median Metrics multivariable logistic regression NIH no significant difference not differ occurred participant Participants past medical history platform positive Post-acute sequelae of SARS-CoV-2 infection predict Predictive predictor Prevalence Primary outcome Prolonged proportions psychological symptom Quantitative reported Research Result Sex significantly significantly higher stressors subjects subsequent Symptom the United State typical symptoms United State
[DOI] 10.3389/fnagi.2021.690383 PMC 바로가기 [Article Type] Neuroscience

Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS-CoV-2 Neutralizing Antibody, Etesevimab, in Chinese Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study

중국의 건강한 성인을 대상으로 한 새로운 SARS-CoV-2 중화 항체인 Etesevimab의 내약성, 안전성, 약동학 및 면역원성: 무작위, 이중 맹검, 위약 대조, 인간 최초의 1상 연구

Clinical Trial

Published on 2021-07-162022-09-12
Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 임상, 진단,

[키워드] acute respiratory syndrome administration Adults adverse event anti-SARS-CoV-2 Anti-spike anti-spike neutralizing antibodies Characteristics Chinese Cohort cohorts comparable coronavirus COVID-19 distribution dose double-blind elimination half-life enrolled etesevimab healthy healthy volunteer immunogenicity intravenous dose JS016 LY3832479 monoclonal antibody Neutralizing Neutralizing antibodies not differ novel participant pharmacokinetics Phase 1 phase 1 study Placebo placebo-controlled profile Randomized receive Registered Safety SARS-CoV-2 single dose Spread TEAE TEAEs the placebo group Tolerability Treatment
[DOI] 10.1128/AAC.00350-21 PMC 바로가기 [Article Type] Clinical Trial

Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome

Research

Published on 2021-07-152022-11-01
Journal: Critical Care [Category] COVID-19, SARS,

[키워드] acute respiratory distress acute respiratory distress syndrome age ARDS body mass index changes in classical clinical trial Compliance correlated COVID-19 COVID-19 patient COVID-19 patients Dead space described difference Evolution include initial longitudinal longitudinal change mechanical ventilation median Mortality Non-COVID-19 non-COVID-19 patient Non-COVID-19 patients not differ not different on mechanical ventilation Oxygenation PaO parameter Patient patients with COVID-19 PEEP physiological Positive end-expiratory pressure Respiratory failure Respiratory mechanics Respiratory system Result severity supplementary material syndrome two group Ventilated ventilatory were used
[DOI] 10.1186/s13054-021-03665-8 PMC 바로가기 [Article Type] Research

Effect of Physician-Delivered COVID-19 Public Health Messages and Messages Acknowledging Racial Inequity on Black and White Adults’ Knowledge, Beliefs, and Practices Related to COVID-19 A Randomized Clinical Trial

Randomized Controlled Trial

Published on 2021-07-142022-10-04
Journal: JAMA Network Open [Category] SARS, 임상,

[키워드] Adults affected age assigned black center clinical Community conducted Control control group control groups COVID-19 COVID-19 knowledge Critical described determine Effect effective Effectiveness eligible evaluate Final finding Gender greater groups Health Importance IMPROVE incidence rate individual information intervention group knowledge less Masks measure message not differ objective participant physician Placebo Point Practice prevention Protective Public randomization randomized clinical trial Randomly receive recorded Registration Relevance Result screened setting social distancing statistically significant Symptoms the disease treatment group Volunteer white women
[DOI] 10.1001/jamanetworkopen.2021.17115 PMC 바로가기 [Article Type] Randomized Controlled Trial

SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical Samples

Major Articles

Published on 2021-07-112022-10-29
Journal: Open Forum Infectious Diseases [Category] COVID-19,

[키워드] A549 acute respiratory syndrome analyzed Cell clinical clinical sample clinical samples clinically Cohort collected coronavirus coronavirus disease correlated COVID-19 cycle Decay kinetics detectable dimethylsulfoxide Favipiravir genomic RNA gRNA in vitro infected with SARS-CoV-2 infectiousness Kinetics Lambda longitudinal marker N-gene not differ Participants patients patients with COVID-19 persistence placebo-controlled polymerase chain potential molecular quantified Quantitative R 2 remained Remdesivir reported Result reverse transcription RNA Sample SARS-CoV-2 sgRNA sgRNAs significantly subgenomic RNA Support Swab symptom onset threshold treated Treatment Trial trials viability Viral RNA
[DOI] 10.1093/ofid/ofab310 PMC 바로가기 [Article Type] Major Articles

Pulmonary fibrosis and its related factors in discharged patients with new corona virus pneumonia: a cohort study

Research

Published on 2021-07-092022-10-28
Journal: Respiratory Research [Category] COVID-19, SARS,

[키워드] Accuracy affecting AUC average BMI chest CT scan cohort study condition conducted COVID-19 COVID-19 patient COVID-19 patients COVID-19 recovered patient develop discharge discharged discharged patient disease early diagnosis effective evaluate Factor feature Fever fibrosis follow-up study groups hospital Hospitalization identify laboratory-confirmed less Lung function not differ NPV Older age Patient patients with COVID-19 PCT persistence persistent Persistent consequences PPV predict Predictive Prevalence pulmonary pulmonary fibrosis Pulmonary function Regression regression analysis required Result reversed risk factor Shenzhen statistically significant the disease the patient traction bronchiectasis turn viral clearance virus
[DOI] 10.1186/s12931-021-01798-6 PMC 바로가기 [Article Type] Research

Early use of nitazoxanide in mild COVID-19 disease: randomised, placebo-controlled trial

Randomized Controlled Trial

Published on 2021-07-082022-10-05
Journal: The European Respiratory Journal [Category] Fulltext, SARS, 임상,

[키워드] 1:1 acute respiratory syndrome Adverse analysed antiviral activity ARMS collected Complete coronavirus coronavirus disease COVID-19 double-blind dry cough enrolled event Evidence fatigue Fever first dose hospitalisation in vitro Infection Inflammation interquartile range Laboratory tests Mild multicentre Nasopharyngeal swab nitazoxanide not differ not significantly different Other outcome Patient Placebo placebo group placebo-controlled trial presenting Primary outcome randomised receive reduced resolution of symptoms reverse transcriptase PCR Safe SARS-CoV-2 SARS-COV-2 infection screened secondary secondary outcome Serious Adverse Event serum biomarker significantly study drug study visit Symptom symptom onset symptom resolution therapy Viral load viral load reduction was reduced
[DOI] 10.1183/13993003.03725-2020 PMC 바로가기 [Article Type] Randomized Controlled Trial

Overcoming COVID-19 in China despite shortcomings of the public health system: what can we learn?

Research

Published on 2021-07-062022-10-31
Journal: Health Economics Review [Category] COVID-19,

Detection of pre-existing SARS-CoV-2-reactive T cells in unexposed renal transplant patients

노출되지 않은 신장 이식 환자에서 기존 SARS-CoV-2 반응성 T 세포 검출

Original Article

Published on 2021-07-062022-09-10
Journal: Journal of Nephrology [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Antigen-spcific T cells Antiviral Blood donors CD4 CD8 Cohort collected competent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines demonstrated detectable detection expression pattern flow cytometry Frequency healthy healthy blood donors healthy individuals immune Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppression magnitude majority Neutralization assay not differ nucleocapsid pandemic Patient patients positive controls pre-existing immunity pro-inflammatory cytokine pro-inflammatory cytokines produced Protective reactive reactivity recent renal Renal transplantation required respiratory Result SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 protein severe acute respiratory syndrome Coronavirus supplementary material T cell T cells Th1 cytokine the SARS-CoV-2 were used
[DOI] 10.1007/s40620-021-01092-0 PMC 바로가기 [Article Type] Original Article