Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistanceAspergillus fumigatus 칼슘 반응성 전사 인자는 스트레스 내성, 독성 및 카스포펀진 내성을 촉진하는 세포벽 구조를 조절합니다Research Article Published on 2019-12-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activated macrophage activated macrophages Activation aspergillosis Aspergillus fumigatus calcineurin calcium calcium metabolism Calcium signaling cause caused Cell cell wall complexity Complicating disease contribute disease disease control drug drug-resistant drugs echinocandin expression functions fungal fungal cell wall fungal cell walls fungal disease gene networks Host host infection humans identify immune response immune responses increasingly Infection influence inhibit inhibitors invasive involved killing life-threatening Localization Lungs Macrophage macrophages mechanism metabolism mice modifications modulating morphology mutant Neutrophils nine osmotic Pathogenesis Pathogens pathway phosphatase polysaccharide pro-inflammatory pro-inflammatory cytokine pro-inflammatory response pro-inflammatory responses promoted reduction in regulate regulated Regulation response responses Screen signaling pathway strain Strains Stress stress response stress response mechanisms stress responses susceptible Tolerance transcription factor transcription factors transcriptomics Treatment turn unique virulence wild-type [DOI] 10.1371/journal.pgen.1008551 PMC 바로가기 [Article Type] Research Article
Ponatinib Protects Mice From Lethal Influenza Infection by Suppressing Cytokine StormOriginal Research Published on 2019-06-212023-06-08 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] Cytokine storm immunomodulator influenza A virus Ponatinib pro-inflammatory cytokine [DOI] 10.3389/fimmu.2019.01393 PMC 바로가기 [Article Type] Original Research
Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-κB activationResearch Paper Published on 2018-10-292022-10-28 Journal: Virulence [Category] Coronavirus, [키워드] activated activating acute enteritis Affect Amino acid amino acid residue bovine cause caused Cell contribute Critical Culture demonstrated domain down-regulation Eagle epithelial cell line exhibited expression fetal gastroenteritis indicated individual Infection infections Inflammation Inflammatory response inhibitor intestinal intestinal inflammation involved IκB monoclonal Necrosis NF-κB NF-κB NF-κB activation nitric oxide NSP2 nuclear p65 Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines Protein Regulation Replication reporter reverse transcription significantly suggested TGEV These data tissue transcription factor transmissible gastroenteritis virus Viral protein virus [DOI] 10.1080/21505594.2018.1536632 PMC 바로가기 [Article Type] Research Paper
In vitro immunomodulatory activity of celastrol against influenza A virus infectionArticle Published on 2018-06-012023-06-23 Journal: Immunopharmacology and immunotoxicology [Category] 신종인플루엔자, [키워드] celastrol immunomodulation Inflammation influenza A virus pro-inflammatory cytokine [DOI] 10.1080/08923973.2018.1440591
Inhibition of neddylation pathway represses influenza virus replication and pro-inflammatory responsesArticle Published on 2018-01-152023-06-23 Journal: Virology [Category] 신종인플루엔자, [키워드] influenza A virus MLN4924 Neddylation pro-inflammatory cytokine [DOI] 10.1016/j.virol.2017.11.004
Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathwaysResearch Article Published on 2017-08-302022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] aa deletion absence activate affected Analysis Apoptosis arginine cellular Characteristics Comparative conserved E protein eight envelope protein epidemic diarrhea ER stress expression Frame functional protein Genes genomic variation glycine GRP78 homologous host cell identification IL-6 IL-8 independent induce Infection membrane fusion morphology Mutation pathway PEDV potential mechanism pro-inflammatory cytokine proliferate proliferation protease Protein Receptor binding Replication responsible S2′ cleavage screened single mutation strain supplementary material transmembrane domain trypsin Variation Vero cells virion virus virus titer whole genome sequence α-coronavirus [DOI] 10.1186/s13567-017-0449-y PMC 바로가기 [Article Type] Research Article
Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive catsResearch Article Published on 2017-04-072022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] addition cause CCL8 Cell clinical sample clinically coronavirus CrFK CXCL10 cytokine definitive diagnosis examined expected expression expression profile fatal disease Feline coronavirus GM-CSF IFNγ IL1β IL6 IL8 immune Immune-mediators immunoassay increase in kidney MCP1 multiplex MX1 PBMC performed plasma pro-inflammatory cytokine profile provide RANTES Real-time PCR responsible Result secretion serum supernatant TNFα Viral load virus [DOI] 10.1186/s12917-017-1019-2 PMC 바로가기 [Article Type] Research Article
Pathogenic Mouse Hepatitis Virus or Poly(I:C) Induce IL-33 in Hepatocytes in Murine Models of HepatitisResearch Article Published on 2013-09-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Acute liver injury addition administration alarmin association cellular controls cytokine down-regulated expressed expressing expression Hepatitis hepatocyte IL-33 in viral Infection involved led to liver Liver injury mice microenvironment Model mouse mouse hepatitis virus murine NK cell NK cells NKT NKT cells over-expressed pathogenic Pathologies Patient poly(I:C post infection pro-inflammatory cytokine receptor Regulation remained sera sinusoidal endothelial cell TLR3 treated up-regulated Vascular vascular endothelial cell Viral hepatitis [DOI] 10.1371/journal.pone.0074278 PMC 바로가기 [Article Type] Research Article