Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens임상 표본에서 SARS-COV-2 단백질을 탐지하는 도구로서 표적화 된 프로테오믹스Research Article Published on 2021-11-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] abundance applied COVID-19 COVID-19 outbreak COVID-19 patient Critical Ct values detect diagnostics infected Vero E6 cells intensity limit of detection mass spectrometry methodology nasopharyngeal swabs nucleocapsid protein PCR peptides Protein proteomics Research SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins sensitivity specimen specimens sputum swabs tryptic peptide tryptic peptides Vero E6 VERO E6 cells Viral Viral protein Viral proteins Viral RNA [DOI] 10.1371/journal.pone.0259165 PMC 바로가기 [Article Type] Research Article
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19초기 IFN-α 시그니처와 지속적인 기능 장애는 심각한 COVID-19에서 NK 세포의 구별되는 특징입니다Multicenter Study Published on 2021-11-092022-09-11 Journal: Immunity [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anti-SARS-CoV-2 Antiviral Cell Clinical course Cohort coronavirus coronavirus disease COVD-19 COVID-19 disease Diseases dysfunction elevated exhibited expression feature fibrosis functional IFN IFN-stimulated gene IFN-stimulated genes IFN-α Immunopathogenesis independent indicate induced genes innate immune system interferon involved ISGs longitudinal Longitudinal analyses lung Lung disease Lung fibrosis moderate Moderate COVID-19 natural killer Necrosis NK cell NK cells outcome Patient performed plasma Plasma levels proteomics respiratory scRNA-seq severe severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling single-cell Single-cell transcriptomics symptom onset TNF TNF response TNF responses transcriptomics Tumor tumor necrosis tumor necrosis factor type 1 IFN. upregulation [DOI] 10.1016/j.immuni.2021.09.002 PMC 바로가기 [Article Type] Multicenter Study
Urinary Protein and Peptide Markers in Chronic Kidney DiseaseReview Published on 2021-11-092023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] Biomarkers Chronic kidney disease proteomics Urine [DOI] 10.3390/ijms222212123 PMC 바로가기 [Article Type] Review
Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic체중 감량 다이어트 중재 중 대사 건강, 신체 구성 및 프로테옴 역학과 관련된 가용성 안지오텐신 전환 효소 2의 시간적 변화: COVID-19 대유행에 대한 의미가 있는 무작위 시험Randomized Controlled Trial Published on 2021-11-082022-09-11 Journal: The American journal of clinical nutrition [Category] SARS, 바이오마커, 임상, [키워드] ACE2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association average baseline biochemical biochemical markers BMI body composition cardiometabolic changes in cholesterol chronic inflammation COVID-19 pandemic COVID-19 pathology decrease diet E-selectin enzyme Examining Factor Fat mass Feature selection female function growth factor HDL Health healthy individual identify implication IMPROVE improvement Improvements Intervention Kidney injury LDL cholesterol Linear regression management marker Mer metabolic health metabolism microglobulin oxidative stress participant peptide placental precursor Protective Protein proteome proteomics pulmonary disease pulmonary diseases randomized trial receptor Registered remained renal renal function risk stratification sACE2 selectin Sex significantly higher soluble ACE2 Temporal thrombomodulin TNF Trial Triglyceride triglycerides tyrosine Vascular injury weight loss weight loss diet intervention. were measured [DOI] 10.1093/ajcn/nqab243 PMC 바로가기 [Article Type] Randomized Controlled Trial
Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis정량적 펩타이드 농축 LC-MS 분석을 사용한 신속하고 민감한 SARS-CoV-2 감염 검출Research Article Published on 2021-11-082022-09-10 Journal: eLife [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analytical method approach asymptomatic individual Asymptomatic individuals Chain Reaction clinical sample clinical samples collected complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cycle threshold detect diagnostics Human LC-MS limit of detection Liquid chromatography mass spectrometer mass spectrometry media molecular pandemic PBS peptide phosphate phosphate-buffered saline polymerase chain polymerase chain reaction positive proteomics Quantitative Rapid respiratory robust RT-PCR SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection sensitivity severe acute respiratory syndrome Coronavirus SISCAPA specificity Swab turnaround time Viral protein Viral proteins virus detection [DOI] 10.7554/eLife.70843 PMC 바로가기 [Article Type] Research Article
Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2병원성 RNA 바이러스에 걸친 바이러스 RNA-숙주 단백질 상호작용의 비교는 SARS-CoV-2에 대한 신속한 항바이러스 약물 발견을 알려줍니다Article Published on 2021-11-042022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 신약개발, 치료제, [키워드] Analysis antiviral drug B.1.351 B.1.351 variant bind broad-spectrum antiviral broad-spectrum antivirals Cell Cell Biology Cepharanthine Comparative Ebola effort engage examined Factor FDA-approved drug hACE2 Host host cell host cells host response IGF2BP1 Infection Interaction pathogen pathogenic Pathogens Perspective promote Protein protein interaction proteomics Research restrict RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 B.1.351 variant transgenic mice translation Trifluoperazine utility Viral viral infection Viral RNA viral RNAs viruses vRNA Zika [DOI] 10.1038/s41422-021-00581-y PMC 바로가기 [Article Type] Article
Expression profile of SARS‐CoV‐2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma정상 구강 점막 및 구강 편평 세포 암종에서 SARS-CoV-2 세포 진입 단백질의 발현 프로파일Short Communication Published on 2021-11-022022-09-11 Journal: Clinical and Experimental Dental Research [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Atla body tissues Cell cellular entry COVID‐19 dataset datasets enzyme Evidence examined except for expression expression level expression levels expression profile expression profiles expression profiling furin head cancer HPA Human independent lesion Microarray moderate mRNA neck cancer objective oral cancer oral mucosa organ organs profile protease Proteases Protein protein expression Proteins proteomics Public relative susceptibility Result risk Risk assessment SARS‐CoV‐2 SARS‐CoV‐2 infection Squamous cell Squamous cell carcinoma tissue tissues TMPRSS2 tongue transcriptomic were used [DOI] 10.1002/cre2.510 PMC 바로가기 [Article Type] Short Communication
NK cell receptor and ligand composition influences the clearance of SARS-CoV-2NK 세포 수용체 및 리간드 구성은 SARS-CoV-2의 제거에 영향을 미칩니다Article Published on 2021-11-012022-09-11 Journal: The Journal of Clinical Investigation [Category] Coronavirus, SARS, 바이오마커, [키워드] activity addition Admission CD155 Cell clearance clearance of SARS-CoV-2 Control correlated COVID-19 cytolytic Diversity expressing expression functional host-pathogen interaction host-pathogen interactions Immune cell immune cells immune response immune responses immune system immune systems infected cells Infection influence intensive care intensive care unit Interaction involved Ligand mechanical ventilation modulate natural killer nectin NK cell NK cells pathway Patient platform proteomics receptor receptors SARS-COV-2 infection single-cell subpopulation subset target cell TIGIT Viral viral clearance rate virus-infected cells [DOI] 10.1172/JCI146408 PMC 바로가기 [Article Type] Article
HDL proteome remodeling associates with COVID-19 severityHDL 프로테옴 리모델링은 COVID-19 중증도와 관련이 있습니다.Article Published on 2021-11-012022-09-11 Journal: Journal of clinical lipidology [Category] MERS, 유전자 메커니즘, 진단, [키워드] 95% confidence interval alteration Altered amyloid A APOF apoM approach clinical criteria coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 complication COVID-19 complications COVID-19 infection death diagnosed with COVID-19 Diseases displaying error rate HDL HDL-C heavy chain high-density High-density lipoprotein Hospitalization hospitalized patients Host immune response Hypothesis increase in Infection Infectious diseases Inflammatory inhibitor ITIH4 lipid metabolism metabolism Mild symptom mild symptoms Odds ratio Particle presenting Protein proteome proteomic proteomics Pulmonary Surfactant quantified Quantitative quantitative proteomics raise Saa1 SAA2 serum amyloid severe symptom severe symptoms severity severity of COVID-19 Sex SFTPB subject subjects the disease Triglyceride triglycerides two groups with COVID-19 [DOI] 10.1016/j.jacl.2021.10.005 PMC 바로가기 [Article Type] Article
Impacts of p97 on Proteome Changes in Human Cells during Coronaviral ReplicationArticle Published on 2021-10-292022-10-31 Journal: Cells [Category] Coronavirus, [키워드] Analysis antiviral activity ATPase Cell cell line cellular senescence change coronavirus cytopathic effects DNA repair early stage favor H1299 HCoV-229E HCoV-OC43 host cell host protein host response Human human cell human lung identify Impact infected cell infected cells Infection inhibit inhibition inhibitor knockdown p97 pathway PROTECT Protein proteome proteomics Quantitative Replication small molecule inhibitor Spread therapeutic target treat Viral RNA virus Virus life cycle virus replication [DOI] 10.3390/cells10112953 PMC 바로가기 [Article Type] Article