Reverse Transcription Recombinase-Aided Amplification Assay With Lateral Flow Dipstick Assay for Rapid Detection of 2019 Novel Coronavirus2019년 신종 코로나바이러스의 신속한 검출을 위한 측면 흐름 딥스틱 분석을 사용한 역전사 재조합효소 보조 증폭 분석Cellular and Infection Microbiology Published on 2021-02-012022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] amplification clinical assessment clinical sample clinical samples conducted coronavirus coronavirus disease coronavirus disease-2019 COVID-19 detection Diagnosis Dipstick Endemic Flow hepatitis B Hepatitis B virus human coronavirus human coronaviruses Influenza influenza A influenza A virus influenza B Laboratory Lateral lateral flow lateral flow dipstick limit of detection novel nucleocapsid offered Pathogens platform POCT Point point of care test positive Primers probe provide pseudovirus public health Quantitative Rapid reaction recombinant plasmid respiratory Respiratory pathogens respiratory syncytial virus Result reverse transcription reverse transcription PCR reverse-transcription recombinase-aided amplification RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA sensitivity severe acute respiratory syndrome coronavirus 2 specificity suspected patient suspected patients targeting Test tested viruses was tested [DOI] 10.3389/fcimb.2021.613304 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
COVID-19 and Infant Hospitalizations for Seasonal Respiratory Virus Infections, New Zealand, 2020Research Letter Published on 2021-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, SARS, [키워드] 2019 novel coronavirus disease age benefit coronavirus disease COVID-19 Hospitalization hospitalizations Infant Infants Infection Influenza Influenza virus introduced Lower respiratory tract lower respiratory tract infection National New New Zealand respiratory respiratory infections respiratory syncytial virus SARS-CoV-2 seasonal severe acute respiratory syndrome coronavirus 2 South Auckland viruses zoonoses [DOI] 10.3201/eid2702.204041 PMC 바로가기 [Article Type] Research Letter
Network theoretic analysis of JAK/STAT pathway and extrapolation to drugs and viruses including COVID-19Article Published on 2021-01-282022-10-04 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] algebraic Analysis Baricitinib Cellular signalling networks Clinical efficacy combinations coronavirus Coronavirus infection correlation COVID-19 Data mining databases drug drugs Effect evade explain Good immunology immunosuppressive agent JAK/STAT JAK/STAT pathway Japanese KEGG Kyoto mathematical measles methotrexate network Nipah virus phenotype Prednisolone R 2 reduction in respiratory syncytial virus rheumatoid arthritis rheumatology tested Tocilizumab Tofacitinib Treatment viral infection viral infections viral system virus West Nile Virus yellow [DOI] 10.1038/s41598-021-82139-x PMC 바로가기 [Article Type] Article
Evaluation of Seasonal Respiratory Virus Activity Before and After the Statewide COVID-19 Shelter-in-Place Order in Northern CaliforniaResearch Published on 2021-01-252022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, [키워드] 95% CI activities activity acute respiratory syndrome age Analysis association cohort study Community conducted coronavirus coronavirus disease Coronaviruses COVID-19 Davis decrease Demonstrating engage enterovirus infection exposure finding Frame Health implication Importance in viral incidence rate include infections Influenza Laboratory Lower maintain measure much lower objective occurred organism other respiratory virus pandemic participant pathogen Pathogens physical distancing Point positive result positive test result Prevent Public public health Regression analyses Relevance respiratory respiratory syncytial virus respiratory viral respiratory virus Result rhinovirus SARS-CoV-2 transmission School seasonal setting statistically significant transmission rate viral respiratory virus wear face masks [DOI] 10.1001/jamanetworkopen.2020.35281 PMC 바로가기 [Article Type] Research
Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8 + T cellsResearch Articles Published on 2021-01-212022-10-28 Journal: Science Immunology [Category] COVID-19, [키워드] Analysis anti-apoptotic CD8 Cell COVID-19 patient cytotoxicity disease dominant enrichment feature Frequency Glycolysis healthy control healthy subject healthy subjects Inflammatory Influenza memory Mild molecular NF-κB signaling Pathways Patient reactive respiratory syncytial virus respond response robust SARS-CoV-2 SARS-COV-2 infection severe COVID-19 illness severe disease single-cell single-cell transcriptome subset T cell T cell memory T cell response T cells transcript two group [DOI] 10.1126/sciimmunol.abe4782 PMC 바로가기 [Article Type] Research Articles
Vitamin D Modulation of the Innate Immune Response to Paediatric Respiratory Pathogens Associated with Acute Lower Respiratory Infections비타민 D가 급성 하부 호흡기 감염과 관련된 소아 호흡기 병원체에 대한 선천 면역 반응 조절Review Published on 2021-01-192024-07-30 Journal: Nutrients [Category] 폐렴구균 감염증, [키워드] acute lower respiratory infections Influenza virus Innate immunity respiratory syncytial virus Streptococcus pneumoniae Vitamin D [DOI] 10.3390/nu13010276 PMC 바로가기 [Article Type] Review
SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory PropertiesImmunology Published on 2021-01-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] acute respiratory syndrome adaptive allergen apoptotic cells Asthma Cell chronic obstructive clearance COPD coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense disease example excessive inflammatory response function HIV homeostasis Human immunodeficiency virus immune system Immunomodulatory agents immunopathology immunoregulation increased risk indicated infections Inflammation inflammatory disease Inflammatory response Inflammatory responses influenza A virus innate immune lung maintain modulate modulating molecule mucosal neutralize Neutralizing noxious offer Particles pathology Prevent property Protein pulmonary disease recombinant recombinant fragment of human SP-D (rfhSP-D) respiratory syncytial virus respiratory viral infection RSV SARS-CoV-2 severe acute respiratory syndrome Coronavirus 2 (2019-nCoV) shown strain surfactant surfactant protein A Surfactant protein D therapeutic therapeutic potential viral infection viral infections virus with COVID-19 [DOI] 10.3389/fimmu.2020.622598 PMC 바로가기 [Article Type] Immunology
Novel dual multiplex real-time RT-PCR assays for the rapid detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus using the BD MAX open systemBD MAX 개방형 시스템을 사용하여 SARS-CoV-2, 인플루엔자 A/B 및 호흡기 세포융합 바이러스의 신속한 검출을 위한 새로운 이중 다중 실시간 RT-PCR 분석Coronaviruses Published on 2021-01-192022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 치료기술, [키워드] analysed BD MAX BD MAX platform Chain Reaction clinical sample clinical samples Coinfection common cold comparable COVID-19 death demonstrated dual evaluated individual Infection Influenza limit of detection multiplex Multiplex PCR nasopharyngeal nasopharyngeal specimen Nasopharyngeal swab novel nucleic acid nucleic acid extraction open Pathogens polymerase chain reaction positive provide Real-time PCR real-time reverse transcription-polymerase chain reaction real-time RT-PCR respiratory respiratory syncytial virus respiratory tract infection RNA standards robust RSV RT-PCR RT-PCR test SARS-CoV-2 sensitivity simultaneous detection Spread Symptom System Taiwan upper respiratory tract upper respiratory tract infection Viral viral pathogen viral pathogens [DOI] 10.1080/22221751.2021.1873073 PMC 바로가기 [Article Type] Coronaviruses
Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion미세융합 억제 시험: 바이러스 매개 세포-세포 융합의 항체 중화 정량화Research Article Published on 2021-01-152022-09-10 Journal: The Journal of General Virology [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibodies antibody Antibody neutralization Antibody Response Antibody responses Antibody-mediated neutralization applicability bimolecular canonical Cell cell–cell fusion cells characterized complexes consequence convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated enveloped virus fusion fusion protein GFP in vivo induce infected cells Infection inhibit inhibition test lack Live virus mAb mAbs mechanism membrane-bound mFIT monoclonal antibody multinucleated cell multinucleated cells natural infection Neutral neutralization Neutralizing antibodies Nipah virus pathogenic performed PIGS plasma quantification receptor engagement Renilla repertoire reported reporter respiratory respiratory syncytial virus RSV SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus specific antibodies Spike protein Spread Syncytia syncytia formation the cell the spike protein triggering vaccination Vaccine immunization Vaccines Viral viral pathogenesis viral spread virus Virus neutralization viruses [DOI] 10.1099/jgv.0.001506 PMC 바로가기 [Article Type] Research Article
Nucleoprotein-based ELISA for detection of SARS-COV-2 IgG antibodies: Could an old assay be suitable for serodiagnosis of the new coronavirus?Article Published on 2021-01-132022-10-04 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Adenovirus anti-nucleoprotein antibody Antibody detection Aspergillus fumigatus Bacterial Concordance confidence interval confirmed case coronavirus COVID-19 cross-reactivity diagnosed ELISA ELISA kit ELISA kits enzyme-linked immunosorbent evaluated Fungal infection healthy controls IgG IgG antibody individual Infection infections Influenza virus Klebsiella pneumoniae majority male Mycobacterium tuberculosis Nucleoprotein antigen objective other respiratory virus Pneumonia Protein protocol reactivity respiratory syncytial virus Result rhinovirus SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV2 sensitivity sera serum IgG serum sample specificity Staphylococcus Streptococcus pneumoniae subject symptom onset virus was determined [DOI] 10.1016/j.jviromet.2021.114064 PMC 바로가기 [Article Type] Article