Mutagenic Distinction between the Receptor-Binding and Fusion Subunits of the SARS-CoV-2 Spike Glycoprotein and Its UpshotArticle Published on 2021-12-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] backbone backbone free energy coronavirus Delta Evolution fusion help Hydrogen bond Mutagenesis mutagenic pressure mutated observation observé omicron residue SARS-CoV-2 SARS-CoV-2 spike spike spike glycoprotein subunit the SARS-CoV-2 Vaccine vaccinology variant variants of concern viral glycoproteins Wuhan-Hu-1 [DOI] 10.3390/vaccines9121509 PMC 바로가기 [Article Type] Article
Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EMArticle Published on 2021-12-202022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor Analysis association Beta biochemical Combination Combined complex complexes conformational conformational state COVID-19 pandemic cryo-EM cryo-EM structure cryo-EM structures Cryoelectron microscopy distribution domain immune evasion IMPROVE mechanism modify Mutation Neutralizing neutralizing antibody pathogenicity Protein RBD Receptor binding recognize S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike spikes Structure the S protein Transmissibility understanding variant variant spike variants virus wild-type [DOI] 10.1038/s41467-021-27350-0 PMC 바로가기 [Article Type] Article
SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infectionResearch Article Published on 2021-12-202022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome anti-spike antibody bind binding binding domain block caused composed coronavirus COVID-19 pandemic demonstrated enzymatic activity enzyme expression Extracellular fused fusion protein globe Health host cell host cells human IgG1 In-vitro Infection inhibit inhibit SARS-CoV-2 Interaction interfere Mutation neutralize Neutralizing not affected physically problem RBD RBD-Ig receptor Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike SARS-CoV-2-infected patients specific treatment spike glycoprotein the RBD the SARS-CoV-2 Treatment viral entry virus virus entry virus infection virus titers [DOI] 10.1371/journal.ppat.1010175 PMC 바로가기 [Article Type] Research Article
IgG antibody titers against SARS-CoV-2 nucleocapsid protein correlate with the severity of COVID-19 patientsSARS-COV-2 뉴 클레오 캡시드 단백질에 대한 IgG 항체 역가 COVID-19 환자의 중증도와 상관 관계가있다.Research Published on 2021-12-182022-09-01 Journal: BMC Microbiology [Category] SARS, 진단, 치료기술, 치료법, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease acute respiratory syndrome acute respiratory syndrome coronavirus addition antibody Antibody titer Antibody titers Asymptomatic asymptomatic and mild cases caused colloidal gold Concordance conducted coronavirus coronavirus disease correlated COVID-19 COVID-19 patients COVID-19 severity critical cases described detection system disease disease severity ELISA ELISA kit Escherichia coli expressed feature geometric mean geometric mean titer gold IgG IgG antibodies IgG antibody IgG antibody titer IgG ELISA immunological Infection investigated mild case mild cases moderate much higher Novel coronavirus novel coronavirus disease nucleocapsid protein Occurrence Patient Protein purified Quantitative ranged recombinant Recombinant nucleocapsid protein respiratory Result S1 protein SARS-CoV-2 SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2 nucleocapsid SARS-CoV-2 spike sensitivity serum dilution severe and critical cases severe cases severity of COVID-19 specificity supplementary material this system virus [DOI] 10.1186/s12866-021-02401-0 PMC 바로가기 [Article Type] Research
Absent antibody production following COVID19 vaccination with mRNA in patients under immunosuppressive treatments면역억제 치료를 받는 환자에서 mRNA로 COVID19 백신 접종 후 항체 생성 없음Article Published on 2021-12-172022-09-11 Journal: Vaccine [Category] MERS, SARS, 진단, 치료기술, [키워드] administration Analysis antibody antibody production Antibody testing B-cell booster vaccinations cellular coronavirus coronavirus disease COVID COVID19 depleting detectable dose evaluated fingolimod Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppressive treatment Infection Inflammatory inhibit lymphocyte maintain Measures metabolic disease Metabolic diseases mRNA ongoing therapies ongoing therapy Patient patients recipients respond responsiveness risk SARS-CoV-2 spike SARS-CoV-2 virus second dose solid organ solid organ transplant specific antibodies subunit T cell T cell proliferation tacrolimus the SARS-CoV-2 virus therapy vaccination Vaccine were measured [DOI] 10.1016/j.vaccine.2021.10.068 PMC 바로가기 [Article Type] Article
Detection and Quantification of SARS-CoV-2 Receptor Binding Domain Neutralization by a Sensitive Competitive ELISA AssayProtocol Published on 2021-12-162022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Accuracy ACE2 added addition Angiotensin converting enzyme-2 binding binding domain binding inhibition assay co-occurrence competitive ELISA condition Containment measure containment measures Control correlated cross-reactivity detect detection Efficacy ELISA ELISA assay high throughput immune include initial interactions Live virus live viruses murine neutralization Neutralization assay Neutralizing non-specific parameter plaque reduction neutralization Precision Prevent protocol R 2 RBD RBD-ACE2 reaction Receptor binding domain SARS-CoV-2 SARS-CoV-2 spike secondary antibody sensitive sensitivity sera serum soluble ACE2 specificity Spike protein stages Treatment Vaccine development validation Virus neutralization VNT [DOI] 10.3390/vaccines9121493 PMC 바로가기 [Article Type] Protocol
Rapid characterization of spike variants via mammalian cell surface displayTechnology Published on 2021-12-162022-10-31 Journal: Molecular Cell [Category] COVID-19, SARS, [키워드] Abstract accelerate ACE2 ACE2 binding Alanine Alpha antibody Antigen antigenicity B.1.1.28 B.1.1.7 B.1.351 B.1.617.2 cell display circulating variant convalescent plasma COVID-19 Critical display ectodomain epitope epitope mapping expression FIVE glycosylated highlight immune system immunogenic mammalian cell Mutagenesis Mutation N-terminal domain neutralizing antibody neutralizing monoclonal antibody NTD peptide platform Proteins Rapid Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike spike variant spike variants Threats Vaccine variant variants variants of concern viral glycoproteins [DOI] 10.1016/j.molcel.2021.11.024 PMC 바로가기 [Article Type] Technology
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escapeSARS-CoV-2를 표적으로 하고 탈출에 저항하는 나노바디의 높은 시너지 조합Research Article Published on 2021-12-152022-09-10 Journal: eLife [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibody binding site Combination conserved effective epitope functional Human identify Infection inhibit SARS-CoV-2 mechanism mechanisms N-terminal domain nanobodies nanobody neutralization Prophylactic Receptor binding domain S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants single-domain antibodies spike glycoprotein subunit synergistic synergy therapeutic therapeutic antibodies Vaccine variants of concern Viral viral escape viral neutralization [DOI] 10.7554/eLife.73027 PMC 바로가기 [Article Type] Research Article
Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury태아 운동 감소 : 주 산기 뇌 손상으로 태반 SARS-COV-2 감염의 징후Case Reports Published on 2021-12-152022-09-10 Journal: Viruses [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Brain brain injury Caesarean section coronavirus COVID-19 cytoplasmic Decreased fetal fetal movements gestation infect Injury leukomalacia Mild MRI Neonatal COVID-19 Neonate neurosonography Perinatal Placenta placental respiratory RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SIGN Transmission vertical transmission [DOI] 10.3390/v13122517 PMC 바로가기 [Article Type] Case Reports
Development of an efficient Sanger sequencing-based assay for detecting SARS-CoV-2 spike mutationsResearch Article Published on 2021-12-142022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Accuracy acute respiratory syndrome amino acid change antibody-resistance approach caused clinical setting coronavirus Culture detect development dose FIVE G142D H655Y helping IMPROVE infective L452R limit of detection management median mutant Mutation mutations N501Y Neutralizing Neutralizing antibodies nine novel nucleotide change patients with COVID-19 primer primer pair SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 transmission Sequencing sequencing-based assay specificity spike gene Spike mutant spike mutation strain TCID the receptor-binding domain tissue Transmissibility virulence [DOI] 10.1371/journal.pone.0260850 PMC 바로가기 [Article Type] Research Article