Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전Review Published on 2022-03-032022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection [DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review
In hospital risk factors for acute kidney injury and its burden in patients with Sars-Cov-2 infection: a longitudinal multinational studyArticle Published on 2022-03-022022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] Acute kidney injury Admission AKI association Care clinical condition clinical conditions Coagulopathy complications conducted contributing to Critical Deterioration Factor help hospital Hospital admission Hospitalization hyperglycemia hypoxic damage identify incidence increase increase in increased mortality Infection Inflammation International Italy kidney Kidney injury Mild Mortality mortality risk Outcomes research Patient patients patients hospitalized patients with AKI remained Respiratory function risk risk factor Russia SARS-COV-2 infection subject susceptibility worsening [DOI] 10.1038/s41598-022-07490-z PMC 바로가기 [Article Type] Article
SARS- CoV-2 infection and oxidative stress in early-onset preeclampsia조기 발병 자간전증에서 SARS-CoV-2 감염 및 산화 스트레스Review Published on 2022-03-012022-09-12 Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 진단, [키워드] Activation ADAM17 affected alteration alterations association cause Characteristics coronavirus disease COVID-19 Cytokine storm disease early-onset Endothelial dysfunction enzyme expressed expression Foetus Frequency functional highlight Human immune system infect infected with SARS-CoV-2 Infection Inflammation lung lung tissue mechanism mechanisms metalloproteinase oxidative stress Placenta placental preeclampsia Pregnancy pregnant women Preterm birth programming renin-angiotensin system reported SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection susceptibility tissue tissue damage Vascular virus with COVID-19 women worsening [DOI] 10.1016/j.bbadis.2021.166321 PMC 바로가기 [Article Type] Review
Allele С (rs5186) of at1r is associated with the severity of COVID-19 in the Ukrainian populationat1r의 대립유전자 С(rs5186)는 우크라이나 인구에서 COVID-19의 심각성과 관련이 있습니다.Observational Study Published on 2022-03-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, 임상, [키워드] A allele allele Analysis angiotensin Angiotensin II Angiotensin II type 1 receptor association AT1R cardiovascular disease Cardiovascular disorders carrier carriers Chain Reaction control subject control subjects coronavirus disease COVID-19 COVID-19 patient COVID-19 patients determined by died Encephalopathy essential hypertension explain Frequency Gene Genotype group Host hypertension indicated invasive Meta-analysis Mortality no difference no differences Non-invasive oxygen Oxygen requirement Oxygen therapy Patient polymerase chain polymerase chain reaction polymorphic variant polymorphism receptor Renin renin-angiotensin system risk factor Risk factors SARS-CoV-2 severe COVID-19 severity severity of COVID-19 significant difference significant differences study population subsequent susceptibility Variability was determined with COVID-19 [DOI] 10.1016/j.meegid.2022.105227 PMC 바로가기 [Article Type] Observational Study
Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations인도 인구 중 COVID-19 사례 사망률과 TMPRSS2 rs2070788 다형성의 유전적 연관성Article Published on 2022-03-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 gene ACE2 receptor Analysis analyzed antagonistic approach Asia Asians association Biomarker Case fatality rate causative agent CFR COVID-19 COVID-19 infection COVID-19 susceptibility disease disease susceptibility disparity East engage eQTL analysis expression Fatality rate Frequency G allele Genetic genetic association Genotype Haplotype help Host host cell increased expression India individual information intensity linkage Linkage disequilibrium lung Next-generation sequencing NGS observation pandemic pathogenicity Phylogenetic polymorphism Population populations positive predict priming risk rs2070788. S protein SARS-CoV-2 Serine serine protease severity significantly higher SNP South South Asian susceptibility tested the SARS-CoV-2 TMPRSS2 variant Variation West with COVID-19 [DOI] 10.1016/j.meegid.2022.105206 PMC 바로가기 [Article Type] Article
Dimerization of SARS-CoV-2 nucleocapsid protein affects sensitivity of ELISA based diagnostics of COVID-19Research article Published on 2022-03-012022-10-05 Journal: International journal of biological macromolecules [Category] SARS, 진단, [키워드] 95% CI acute respiratory syndrome Affect Antigen antigenicity characterized composed coronavirus COVID-19 COVID-19 diagnosis diagnostic diagnostics dimeric E. coli elevated ELISA enzyme-linked immunosorbent expressed forms highest immunological IMPROVE indicate indicated maintain modelled structure MONITOR monoclonal antibody monomeric N protein N-protein nucleocapsid protein Protein purified robust SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sensitivity Sensitivity and specificity severe acute respiratory syndrome coronavirus 2 solvent stability susceptibility the N protein virus [DOI] 10.1016/j.ijbiomac.2022.01.094 [Article Type] Research article
Attitudes toward Vaccinations and Vaccination Coverage Rates among Dental Students in GreeceArticle Published on 2022-03-012022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, [키워드] Attitude booster Care Coverage COVID-19 dental dental school dental students dentist disease Diseases Greece healthcare personnel Hepatitis hepatitis B High-risk patients Immunity immunization Influenza mandatory Mandatory vaccination mumps National poliomyelitis Rate School student susceptibility university vaccination vaccination rate Vaccinations varicella [DOI] 10.3390/ijerph19052879 PMC 바로가기 [Article Type] Article
Seroprevalence of IgG antibodies against SARS-CoV-2 – a serial prospective cross-sectional nationwide study of residual samples, Belgium, March to October 2020SARS-CoV-2에 대한 IgG 항체의 Seroprevalence - 잔류 샘플에 대한 연속 전향적 전국 횡단 연구, 벨기에, 2020년 3월~10월Article Published on 2022-03-012022-09-11 Journal: Eurosurveillance [Category] MERS, SARS, 진단, 치료기술, [키워드] age ambulatory patient ambulatory patients analysed Belgium COVID-19 credible interval cross-sectional detectable ELISA Epidemic epidemic waves epitope estimate Evolution exposure to fraction humoral Humoral immunity IgG antibodies IgG antibody lifted lockdown measure National performed resulting S1 protein SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 S1 epitope SARS-CoV-2 S1 protein SARS-CoV-2 seroprevalence sensitivity sera serial sero-survey Serologically Seroprevalence seroprevalence seroincidence. Seven Sex significant decrease stratified susceptibility the SARS-CoV-2 [DOI] 10.2807/1560-7917.ES.2022.27.9.2100419 PMC 바로가기 [Article Type] Article
Predictive factors of insomnia during the COVID-19 pandemic in Bangladesh: a GIS-based nationwide distribution방글라데시 코로나19 팬데믹 기간 불면증 예측인자: GIS 기반 전국 분포Article Published on 2022-03-012022-09-11 Journal: Sleep medicine [Category] 치료제, [키워드] adverse outcome Analysis approach Bangladesh Comorbidities conducted country COVID-19 COVID-19 pandemic COVID-19 psychological impact cross-sectional cross-sectional study daytime demographics determinants distribution exhibit exploration Factor fear Fear of COVID-19 female gender form General population Geographic Geographic information system GIS-Based nationwide study heterogeneity identify implementation Information System Insomnia investigated knowledge measure media Mental moderate multifactorial pandemic participant Predictive presence of comorbidities Prevalence prevalent problems Psychological psychological Impact questionnaire reported risk factor significantly Sleep sleep problems sleep quality social media susceptibility Symptom System targeting Variability Variation [DOI] 10.1016/j.sleep.2021.04.025 PMC 바로가기 [Article Type] Article
Racial and ethnic disparities in cardiometabolic disease and COVID-19 outcomes in White, Black/African American, and Latinx populations: Physiological underpinningsReview article Published on 2022-03-012022-10-05 Journal: Progress in Cardiovascular Diseases [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Affect alteration black cardiometabolic disease cardiovascular disease caused characterized conditions contagious Coronavirus disease 2019 Coronavirus-2 COVID-19 CVD greater groups Health Health disparities Hospitalization increased risk individual Latinx metabolic disease Mild moderate morbidity and mortality Mortality obesity outcome pandemic pathophysiology physiological Population populations Prevalence Racial Respiratory illness risk SARS-CoV-2 severe COVID-19 social determinant susceptibility Symptoms the United State Variation while white [DOI] 10.1016/j.pcad.2022.04.005 [Article Type] Review article