Viral clearance after early corticosteroid treatment in patients with moderate or severe covid-19중등도 또는 중증 코로나19 환자에서 조기 코르티코스테로이드 치료 후 바이러스 제거Article Published on 2020-12-042022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료법, 치료제, [키워드] Admission Analysis baseline clearance Corticosteroid corticosteroid treatment Corticosteroids COVID-19 Cox model determine difference Diseases duration of symptom early treatment evaluate Factor Hospitalization hospitalized COVID-19 patients Infectious diseases Italy lymphocyte Lymphocyte count mmHg multivariable multivariate Multivariate analysis Nasopharyngeal swab nasopharyngeal swabs Older age PaO Patient patients with moderate Primary outcome proportion Retrospective analysis San Raffaele Hospital SARS-CoV-2 clearance severe disease steroid Steroids time treated use of corticosteroids viral infection [DOI] 10.1038/s41598-020-78039-1 PMC 바로가기 [Article Type] Article
COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular TrapsReview Article Published on 2020-12-022022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress ARDS Bacteria clearance Coronavirus disease 2019 COVID-19 COVID-19 symptom Critical Cytokine storms Cytokines dysfunction excessive inflammation highlight hyperinflammation immunopathological Inflammation Interaction leukocyte Lung diseases mechanism NET NETosis NETs neutrophil Neutrophil extracellular trap neutrophil function neutrophil response neutrophilic pathway relationship Respiratory disease syndrome triggered viral infection viral infections viruses [DOI] 10.1155/2020/8829674 PMC 바로가기 [Article Type] Review Article
Risk factors for prolonged viral clearance in adult patients with COVID-19 in Beijing, China: A prospective observational studyObservational Study Published on 2020-12-012022-10-05 Journal: International immunopharmacology [Category] SARS, 임상, [키워드] analyzed Beijing center changes in clearance collected correlation Course COVID-19 COX elevated Factor hypertension IL-6 Laboratory lactate dehydrogenase lymphocyte median multivariable NK cell observation Patient patients with COVID-19 positive prospective observational study regression models remained risk factor Risk factors SARS-CoV-2 serum the disease the patient treated two group univariable viral clearance viral nucleic acid virus clearance [DOI] 10.1016/j.intimp.2020.107031 PMC 바로가기 [Article Type] Observational Study
Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease중증 질환이 있는 COVID-19 환자의 질병 진행을 이해하기 위한 혈장 내 SARS-CoV-2 항원 및 항체의 초민감 직렬 프로파일링Article Published on 2020-12-012022-09-11 Journal: Clinical Chemistry [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus analyzed anti-SARS-CoV-2 Antigen Biomarker Blood changes in clearance clinical outcomes Clustering Combined Concentration coronavirus coronavirus disease COVID-19 COVID-19 case COVID-19 negative COVID-19 positive patients detect detectable Disease progression Hierarchical hierarchical clustering ICU admission identify Infection intubation longitudinal plasma samples molecule MONITOR N antigen nasopharyngeal nucleocapsid antigen nucleocapsid antigens Patient patients patients with COVID-19 PCR plasma plasma sample positive positive result Profiling quantified reported respiratory Respiratory failure RT-PCR test S1 subunit SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 S1 SARS-CoV-2 spike SARS-CoV-2 viral Seroconversion serological serological assays serology tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Simoa single molecule arrays statistically significant test results These data Viral Viral antigen viral antigens [DOI] 10.1093/clinchem/hvaa213 PMC 바로가기 [Article Type] Article
Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device Research Published on 2020-12-012022-10-05 Journal: Nature biomedical engineering [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome automated clearance Concordance Diagnosis facilitate fluorescence detection fluorescence intensity Genes healthy controls Infection Laboratory nasopharyngeal Nucleic acid detection Oropharyngeal patients with COVID-19 Pearson point of care quantitative PCR reverse transcription RPP30 SARS-CoV-2 SARS-CoV-2 RNA Sputum sample [DOI] 10.1038/s41551-020-00654-0 [Article Type] Research
Physiologically-Based Pharmacokinetic Modeling to Predict the Clinical Efficacy of the Coadministration of Lopinavir and Ritonavir against SARS-CoV-2SARS-CoV-2에 대한 로피나비르와 리토나비르의 병용 투여의 임상 효능을 예측하기 위한 생리학적 기반 약동학 모델링Article Published on 2020-12-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Chinese clearance clinical Clinical studies clinical study clinically Concentration coronavirus correlation dataset diarrhea disorder dose dosing regimen effective Efficacy exhibit greater half-life half-maximal effective concentration HIV in vitro in vivo lead Lopinavir Lopinavir/ritonavir lung lung tissue modeling nausea parameters pharmacokinetic plasma plasma concentration populations QT prolongation regimen repeated respiratory Ritonavir SARS-CoV-2 severe acute respiratory syndrome Coronavirus vomiting weighed [DOI] 10.1002/cpt.2014 PMC 바로가기 [Article Type] Article
Management of immune checkpoint therapy for patients with cancer in the face of COVID-19코로나19에 직면한 암환자의 면역관문치료 관리Article Published on 2020-12-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] SARS, 바이오마커, [키워드] administration adverse effect Antiviral assist Biomarkers caused Chronic diseases clearance coronavirus COVID-19 COVID-19 outbreak death Decision-making ENhance expression immune Immune checkpoint inhibitor Immune checkpoint inhibitors Immunopathogenesis immunopathological damage Immunotherapy in some Inflammation malignant tumor marker medical system MONITOR pandemic Pathogenesis pathogenic Patient Patients with cancer receiving respiratory Respiratory disease respiratory diseases risk SARS-CoV-2 subset T-cell Th1 Th17 therapy Treatment Tumor Usage virus [DOI] 10.1136/jitc-2020-001593 PMC 바로가기 [Article Type] Article
Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndromeClinical Trial Published on 2020-12-012022-10-05 Journal: The Journal of Clinical Investigation [Category] 임상, [키워드] 28-day mortality 95% CI acute respiratory distress adjusted all-cause mortality Analysis ARDS Chinese hospitals clearance competing conducted Corticosteroid corticosteroid therapy Corticosteroids COVID 19 COVID-19 Cox proportional hazard dose Eligible patients Hospitalization IQR Liver injury mechanical ventilation median time Mortality Myocardial Patient performed Respiration risk RNA SARS-CoV-2 coronavirus SARS-CoV-2 RNA severe COVID-19 patient Shock syndrome Treatment usual care [DOI] 10.1172/JCI140617 PMC 바로가기 [Article Type] Clinical Trial
Chloroquine, hydroxychloroquine, and COVID-19: Systematic review and narrative synthesis of efficacy and safetyResearch article Published on 2020-12-012022-10-05 Journal: Saudi Pharmaceutical Journal : SPJ [Category] 신약개발, [키워드] adverse event Arrhythmias Chloroquine clearance clinical trial clinical trials clinician control group COVID-19 COVID-19 pandemic diagnosed drugs Efficacy Efficacy and safety Endpoint Evidence greater HCQ hospitalised COVID-19 patients human clinical trial Hydroxychloroquine identify incidence no significant difference observational study outcomes Probability Prophylaxis QTC prolongation required Safety Side-effects significant difference systematic review therapy treated patient Treatment unique Viral transmission [DOI] 10.1016/j.jsps.2020.11.003 [Article Type] Research article
Molecular and serological characterization of SARS-CoV-2 infection among COVID-19 patientsCOVID-19 환자 중 SARS-CoV-2 감염의 분자 및 혈청학적 특성Article Published on 2020-12-012022-09-11 Journal: Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] addition Admission anal swab analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody Response Blood clearance clinical information Cohort collected COVID-19 COVID-19 patient COVID-19 patients demographic detectable different time point different time points disease severity Diseases Evidence immunoassays infection control intestine investigated levels of antibodies levels of antibody management median Mild moderate moderate symptoms Most patients multiple tissue multiple tissues nasal Novel coronavirus occurred Patient Patient management patients pharyngeal positive qRT-PCR reached respiratory respiratory sample Respiratory samples Respiratory system RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA scientific evidence sensitivity serological severity significant difference Specific specimen swabs Symptoms the disease the patient variable Viral viral kinetics Viral load Viral protein Viral proteins Viral RNA were measured [DOI] 10.1016/j.virol.2020.09.008 PMC 바로가기 [Article Type] Article