Viral pandemic preparedness: A pluripotent stem cell-based machine-learning platform for simulating SARS-CoV-2 infection to enable drug discovery and repurposing바이러스 대유행 대비: SARS-CoV-2 감염을 시뮬레이션하여 약물 발견 및 용도 변경을 지원하는 만능 줄기 세포 기반 기계 학습 플랫폼Article Published on 2021-02-012022-08-31 Journal: Stem cells translational medicine [Category] SARS, 신약개발, [키워드] alveolar Antiviral approved drug Cell clinical study clinical testing clinical trial Combination computer simulations creating DeepNEU distribution drug drug combination drug combinations Drug discovery drug discovery and repurposing Drug repurposing effective evaluate global pandemic identify imperative IMPROVE infected with SARS-CoV-2 lab lab data lung cell machine-learning Outbreaks pandemic pandemic preparedness performed platform potential therapeutic target potential therapeutic targets repurposing Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus the SARS-CoV-2 virus therapeutic option therapeutic target unsupervised learning unsupervised learning. Vaccine Vaccine development Viral viral genome [DOI] 10.1002/sctm.20-0181 PMC 바로가기 [Article Type] Article
Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach체계적인 가상 스크리닝 접근법을 통한 COVID-19 치료를 위한 잠재적인 Mpro 억제제 식별Article Published on 2021-02-012022-09-11 Journal: Molecular diversity [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] acute respiratory syndrome amides antiviral agent Antiviral agents approach approved Asinex BioDesign carried caused China clinically Compound conformational Corona virus coronavirus COVID-19 creating derivatives diagnostic drug drug library exhibiting FDA genomic RNA globe identification inhibitor inhibitors Interaction iodixanol iotrolan lead limitations Modification MPro nelfinavir non-structural protein non-structural proteins Novel coronavirus pathogen pharmacophore polyprotein polyproteins pralmorelin Precision predicted produced protease pyrazoles PYRROLIDINE respiratory Respiratory complications Ritonavir saquinavir SARS-CoV-2 Screening screenings Severe acute respiratory syndrome Spread target protein therapeutic agent therapeutic agents translation Treatment Virtual screening virus Virus Disease worldwide pandemic [DOI] 10.1007/s11030-020-10130-1 PMC 바로가기 [Article Type] Article
Diffusion segregation and the disproportionate incidence of COVID-19 in African American communities1004 Published on 2021-01-272022-10-30 Journal: Journal of the Royal Society Interface [Category] COVID-19, MERS, [키워드] Affect African American African Americans black co-morbidity co-occurrence Community concerning COVID-19 COVID-19 incidence COVID-19 pandemic creating death diffusion Diseases ethnic group ethnic segregation explain Factor groups healthcare human mobility incidence incidence of COVID-19 Infection Mortality pandemic random walks Risk factors significantly urban systems virus [DOI] 10.1098/rsif.2020.0961 PMC 바로가기 [Article Type] 1004
First report on prevalence of SARS-CoV-2 infection among health-care workers in Nicaragua니카라과의 의료 종사자들 사이에서 SARS-CoV-2 감염의 유병률에 대한 첫 번째 보고서Research Article Published on 2021-01-272022-09-10 Journal: PLoS ONE [Category] MERS, 치료기술, [키워드] age America Asymptomatic Comorbidities Comorbidity Complication coronavirus correlation correlations COVID-19 COVID-19 situation creating crisis death determine exceptional exponential growth FIVE Government growth health-care Healthcare system higher risk hospitals independent independent of infected with SARS-CoV-2 isothermal amplification Loop-mediated isothermal amplification male median age medical assistants Nurse Nurses participant patients Physicians positive PPE Prevalence Probability questionnaire reported restrict risk risk factor Risk factors Saliva saliva samples SARS-CoV-2 SARS-COV-2 infection Sex Spread Study participants Symptom tested These data was performed [DOI] 10.1371/journal.pone.0246084 PMC 바로가기 [Article Type] Research Article
To stress or not to stress: Brain-behavior-immune interaction may weaken or promote the immune response to SARS-CoV-2Article from the Special Issue on Neurobiology of Stress related to Covid-19 Published on 2021-01-272022-10-30 Journal: Neurobiology of Stress [Category] COVID-19, [키워드] (Nor)adrenaline Affect attenuate can be used Care contribute Course COVID-19 COVID-19 disease COVID-19 pandemic creating detrimental Disadvantages effort Factor form Health hypothalamic-pituitary-adrenal axis immune activation immune defense immune response Immune suppression IMPROVE increase in Interaction Intervention knowledge management mechanism medical system Neuropeptide Neurotrophin Patient prevention promote Psychosocial stress question Research respiratory viral infection responses against SARS-CoV-2 SARS-COV-2 infection Stress Stress reduction Viral diseases viral infections [DOI] 10.1016/j.ynstr.2021.100296 PMC 바로가기 [Article Type] Article from the Special Issue on Neurobiology of Stress related to Covid-19
Environments, processes, and outcomes – using the LEPO framework to examine medical student learning preferences with traditional and electronic resourcesResearch Article Published on 2021-01-262022-10-29 Journal: Medical Education Online [Category] Coronavirus, SARS, [키워드] change changes in Characteristics COVID-19 pandemic creating Critical effective Effectiveness Environment help identify information learning learning environments learning outcomes Learning preferences learning processes majority Mann-Whitney U medical school curricula medical students outcome participant preference preferences proportion reported resource resources response School Schools step student third-party resources traditional resources understanding was used Z-tests [DOI] 10.1080/10872981.2021.1876316 PMC 바로가기 [Article Type] Research Article
Pandemic-related attitudes, stressors and work outcomes among medical assistants during the SARS-CoV-2 (“Coronavirus”) pandemic in Germany: A cross-sectional StudyResearch Article Published on 2021-01-142022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] age Anxiety assistant children Complete consequence Contact creating cross-sectional Depression determinants disorder Evidence feeling female Germany globe identify increased risk Infection information investigated Major outcome outcomes pandemic Patient PHQ-2 provide provided Psychological question questionnaire Result SARS-CoV-2 SARS-CoV-2 virus screened significantly Spread Stressor stressors study population Support symptoms of depression the SARS-CoV-2 thought virus was performed were measured [DOI] 10.1371/journal.pone.0245473 PMC 바로가기 [Article Type] Research Article
CIoTVID: Towards an Open IoT-Platform for Infective Pandemic Diseases such as COVID-19Technical Note Published on 2021-01-122022-10-29 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, MERS, [키워드] acquisition affecting aggregation Analysis benefit Certain disease Classifier clinics collected combating composed contagious COVID-19 COVID19 creating disease Factor Health heterogeneous individuals Internet IoT platform medical condition outbreak pandemic pandemic of COVID-19 penetration platform Spectrogram speech analysis tested Validity Volume [DOI] 10.3390/s21020484 PMC 바로가기 [Article Type] Technical Note
Conservation physiology and the COVID-19 pandemicAcademicSubjects/SCI00840 Published on 2021-01-122022-10-31 Journal: Conservation Physiology [Category] COVID-19, [키워드] alteration Biomarker can be used Community condition conservation coronavirus COVID-19 COVID-19 pandemic creating disease ecosystem Effect Emissions environmental change generate Health identify impacted include likelihood lockdown Measures mitigate one health outbreak pandemic Pandemics pathogen pathway physiological consequence positioned public health measure recruitment reduce Regulatory Research researcher risk robust Stress Support threshold transfer wildlife zoonoses zoonotic [DOI] 10.1093/conphys/coaa139 PMC 바로가기 [Article Type] AcademicSubjects/SCI00840
Lung ultrasound score predicts outcomes in COVID-19 patients admitted to the emergency departmentResearch Published on 2021-01-112022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI age approved AUC average calculated Chest CT conducted correlated correlation COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients creating Critical care death Diagnosis disease severity eligible Emergency emergency medicine Endotracheal intubation enrolled high accuracy Hospital admission ICU admission local Ethics Committee lung male Older outcome outcomes parenchymal Patient performed physician predict primary endpoint prospective cohort study Prospective Study protocol reducing Respiratory failure Result secondary endpoint severe acute respiratory syndrome coronavirus 2 trauma Ultrasonography was tested [DOI] 10.1186/s13613-020-00799-w PMC 바로가기 [Article Type] Research