Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brainResearch Published on 2012-09-212022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] addition Adenovirus administration against SARS-CoV airway Antibody Response Antigen Brain CD8 comparable coronavirus effective examined IgA IgA antibody immune response Immunity immunization inactivated viruses indicate induce infect Infection intramuscular intranasal lung mice mucosa mucosal mucosal route Neutralizing olfactory protective immunity protein antigens recombinant recombinant adenovirus Result Safe SARS-CoV SARS-CoV spike protein serum Severe acute respiratory syndrome shown Spike protein Sublingual Sublingual administration T cell T cell response tissues vector virus Virus-like particle [DOI] 10.1186/1743-422X-9-215 PMC 바로가기 [Article Type] Research
A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virusClinical Trial Published on 2010-05-112022-10-06 Journal: Proceedings of the National Academy of Sciences of [Category] 진단, [키워드] acquisition Administered Adult Adults Analysis antibody antiviral activity Antiviral effect assays clinical evidence concentrations decrease different double-blind Effectiveness enrolled exhibiting Factors healthy subject Human increase in independent Infected infected children Infection intranasal mechanism mRNA multiple logistic regression murine model nasal nasal washe nucleocapsid number of infected PCR Placebo placebo-controlled study placebo-controlled trial Proinflammatory cytokine proportion Protein protein expression Randomized recipient recipients representing respiratory syncytial virus RNA RSV RSV infection safety profile saline placebo significantly lower siRNA subjects tested therapeutic Therapeutic approach therapy treat uninfected unique viral culture was measured wild-type [DOI] 10.1073/pnas.0912186107 PMC 바로가기 [Article Type] Clinical Trial
A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal VaccinationResearch Article Published on 2009-01-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Antigen Chinese dissemination doses Efficacy experiments generate genomic location Head-to-head comparison implication Inducing inoculated intramuscular intranasal Level maintain mice mucosal neutralizing antibody novel offer Prevent protective immune response response S gene SARS-CoV SARS-CoV neutralizing antibody spike glycoprotein Superior Tian vaccination Vaccine vaccine candidate vaccinia variant vector Viral transmission Viral vector was used wild-type [DOI] 10.1371/journal.pone.0004180 PMC 바로가기 [Article Type] Research Article
MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoVResearch Article Published on 2008-12-122022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 2003 absence adapter addition animal model antiviral therapies Atypical Author BALB/c mice C57BL/6 caused Cell characterized chemokine Chemokine receptor chest X-ray China circulating Clinical course compared contribute coronavirus correlated Course CoV death disease disease pathogenesis early response exhibited expression Factor function Genetic greater Host host gene Host immune response humans identify immune immune system Infection Inflammatory Inflammatory response innate immune intranasal Laboratory lethal Lower respiratory tract lung Lung inflammation lung tissue Lungs mice monocyte monocytes/macrophage Mortality mouse-adapted SARS-CoV Pneumonia Post-infection Proinflammatory cytokine protection Protein provide Pulmonary pathology receptor recruitment Replication required respiratory virus respond SARS-CoV SARS-CoV infection severe lung pathology Signaling significantly higher Spread susceptible TLR Travel Viral load viral loads viral replication virus wild-type [DOI] 10.1371/journal.ppat.1000240 PMC 바로가기 [Article Type] Research Article