Transferrin receptor 1 is a supplementary receptor that assists transmissible gastroenteritis virus entry into porcine intestinal epitheliumResearch Published on 2018-10-202022-10-31 Journal: Cell Communication and Signaling : CCS [Category] Coronavirus, [키워드] age Anemia antibody assist blocked Caco-2 cell cell line Clustering diarrhea down-regulated epithelial cell expressed expression Extracellular gastroenteritis Hypothesis infect Infection inhibited interact intestinal epithelium Invasion investigated IPEC-J2 cells mechanism mortality rate Newborn over-expressed primary target cell promoted Protein receptor Replication Result S1 protein significantly supplementary material Support TGEV transferrin receptor 1 transmissible gastroenteritis virus viral infection virus entry vomiting [DOI] 10.1186/s12964-018-0283-5 PMC 바로가기 [Article Type] Research
In vitro invasion capacity of Salmonella Typhimurium DT9 isolates sourced from humans and layer hen environmentsArticle Published on 2018-02-012023-06-21 Journal: Zoonoses and Public Health [Category] 조류인플루엔자, [키워드] Caco2 cells Invasion MLVA repetitive element PCR. Salmonella Typhimurium [DOI] 10.1111/zph.12434 PMC 바로가기
Oral Delivery of Probiotics Expressing Dendritic Cell-Targeting Peptide Fused with Porcine Epidemic Diarrhea Virus COE Antigen: A Promising Vaccine Strategy against PEDVArticle Published on 2017-10-252022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Lactobacillus Antigen antigen-presenting cells approach Cellular immune response COE coronavirus DCs delivery dendritic cell dendritic cell-targeting peptide diarrhea Efficiency elicit ENhance epidemic diarrhea epitope expressing fused fusion protein homeostasis humoral humoral immune response immune immune response Immunoglobulin in vivo induce Infection intestinal intestinal epithelial cell Invasion Lactobacillus casei Mortality mucosal Neonatal Neutralizing oral Oral vaccine PEDV PEDV COE antigen peptide Probiotics protective immunity reported secretory immunoglobulin A Significant Strategy vaccination Vaccine vaccine antigen virus [DOI] 10.3390/v9110312 PMC 바로가기 [Article Type] Article
Porcine Hemagglutinating Encephalomyelitis Virus Enters Neuro-2a Cells via Clathrin-Mediated Endocytosis in a Rab5-, Cholesterol-, and pH-Dependent MannerVirus-Cell Interactions Published on 2017-09-272022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] Actin activated Activation Analysis antiviral drug approach cause Cell cells cellular entry Central nervous system China cholesterol clathrin Clathrin-mediated endocytosis CNS confocal microscopy contagious coronavirus death disease dissect dominant negative dysfunction Encephalomyelitis endocytic pathways endocytosis etiological agent Exocytosis GTPase Guidance Host infected cell Infection Invasion investigated involved knowledge mechanism molecular mechanism mutant nerve cell Neural neurological neurovirulent neurovirulent coronavirus occur overexpression Pathogenesis pathway performed pharmacological porcine hemagglutinating encephalomyelitis virus positive-sense positively correlated progression Rab required RNA coronavirus RNA interference single-stranded suggested target TEM Therapeutic strategies transfer transmission electron microscopy understanding viral endocytosis viral entry viral entry pathway virus virus particles were used [DOI] 10.1128/JVI.01083-17 PMC 바로가기 [Article Type] Virus-Cell Interactions
Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infectionsResearch Article Published on 2017-01-142022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, MERS, [키워드] age antimicrobial agent Antiviral ARMS Barrier formation cetylpyridinium chloride clinical trial Comparisons component conducted Contact coronavirus cough current demonstrated double-blind double-blinded Effectiveness Efficacy enrolled evaluate Frequency Glycerin had no Host individual Influenza Invasion medication mucosa not differ not significant occurred outcome pilot clinical trial placebo group placebo-controlled placebo-controlled clinical trial proof-of-concept clinical trial Prophylaxis Randomized reduced reducing reduction Registered reported representing Result rhinovirus Safe Secondary objective severity significantly sore throat statistically study outcomes study participant Study participants subject supplementary material the placebo group Tolerability treatment of influenza upper respiratory infection vaccination virus detection was reduced Xanthan gum [DOI] 10.1186/s12879-016-2177-8 PMC 바로가기 [Article Type] Research Article
Directional and reoccurring sequence change in zoonotic RNA virus genomes visualized by time-series word countArticle Published on 2016-11-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] activity addition analysis change changes in condition diagnostic directional Ebola Ebolavirus Effectiveness Epidemics Factors Genome growth Host hosts human cell influenza A influenza A virus Influenza virus Invasion Long MERS coronavirus Middle East mutate oligonucleotide outbreak primer RNA virus RNA viruses RT-PCR sequence siRNAs subtype Subtypes therapeutic thought virus West zoonotic [DOI] 10.1038/srep36197 PMC 바로가기 [Article Type] Article
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article
Standard and AEGIS nicking molecular beacons detect amplicons from the Middle East respiratory syndrome coronavirusArticle Published on 2016-07-122022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] activate Amplicon amplification complex component copy detect DNA and RNA downstream eliminated enzyme genetic information IMPROVE Invasion MERS-CoV MERS-CoV RNA Middle East molecular Nicking Nicking molecular beacon nucleotide Older primer respiratory respiratory syndrome coronavirus respiratory virus reverse transcription PCR RT-PCR sensitivity shown Standard Support Synthetic biology nucleotides Viral RNA was used [DOI] 10.1016/j.jviromet.2016.07.008 PMC 바로가기 [Article Type] Article
Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesiArticle Published on 2016-06-282023-06-03 Journal: Proceedings of the National Academy of Sciences of [Category] 조류인플루엔자, [키워드] Invasion malaria parasite normocyte-binding protein Plasmodium knowlesi zoonotic malaria. [DOI] 10.1073/pnas.1522469113 PMC 바로가기
Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinomaResearch Published on 2016-05-262023-06-03 Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] B형 간염, [키워드] Hepatocellular carcinoma Invasion Metastasis Metastasis suppressor 1 [DOI] 10.1186/s13046-016-0361-8 PMC 바로가기 [Article Type] Research