Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvantArticle Published on 2021-11-082022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] addition adjuvants Antigen antigen-specific antibody B.1.1.7 B.1.351 variant binding Body weight loss Cellular immune response convalescent plasma COVID-19 pandemic evaluated humoral Infectious diseases mice Neutralizing Neutralizing activity platform protein subunit vaccine Protein vaccines reducing robust SARS-CoV-2 SARS-CoV-2 vaccine single vaccination SLA sulfated the spike protein Vaccine Vaccines viral infection Viral load viral spike [DOI] 10.1038/s41598-021-01363-7 PMC 바로가기 [Article Type] Article
Development of a rapid point-of-care test that measures neutralizing antibodies to SARS-CoV-2Article Published on 2021-11-042022-10-04 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, [키워드] ACE2 angiotensin-converting enzyme 2 assays baseline binding Blood COVID-19 COVID-19 vaccine demonstrated development dose individual individuals infected individual infected individuals Infection lateral flow lateral flow assay measure microneutralization mRNA vaccine neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody non-infected Patient patients with COVID-19 plasma point-of-care RBD receiving recipient respiratory virus Result ROC Curve SARS-CoV-2 SARS-CoV-2 microneutralization assay seasonal coronavirus second dose semi-quantitative sera tested the receptor-binding domain vaccine dose vaccine doses Whole blood [DOI] 10.1016/j.jcv.2021.105024 PMC 바로가기 [Article Type] Article
LB9. Longitudinal antibody dynamics in children infected with SARS-CoV-2 through 6 months post-infectionLate Breaker Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] Abbott acute respiratory syndrome antibody Antibody titer Architect AstraZeneca binding Blood blood sample CDC changes in children collected Community consultant convalescent sera coronavirus COVID-19 vaccine decrease detectable Diagnosis elicit enrolled evaluate examined figure Flagship GlaxoSmithKline had no Hospitalized Immunocompromised Immunosuppression include infected with SARS-CoV-2 Infection Jesse laboratory-confirmed SARS-CoV-2 infection longitudinal Meissa Moderna neutralization potency neutralization titer Neutralizing Neutralizing activity neutralizing titers nucleocapsid Outpatient participant Pfizer pharmaceutical Post-infection Protein provided recruited reduction Result Sanofi Pasteur SARS-CoV-2 SARS-CoV-2 immunity Seattle Children’s Hospital supported symptomatic and asymptomatic symptomatic disease undetectable Viral protein Volunteer were assessed with COVID-19 [DOI] 10.1093/ofid/ofab466.1640 PMC 바로가기 [Article Type] Late Breaker Abstracts
SARS-CoV-2 variants and effectiveness of vaccines: a review of current evidenceSARS-CoV-2 변이체 및 백신의 효과: 현재 증거 검토Review Published on 2021-11-042022-09-11 Journal: Epidemiology and Infection [Category] MERS, SARS, 변종, 진단, [키워드] Adenovirus administration Alpha B.1.617.2 binding circulating variant contagious Delta dominant Effectiveness Epsilon Evidence human ACE2 receptor Immune escape increase morbidity Mortality mRNA Mutagenesis natural infection Neutralizing activity pandemic Protein provoke public health Recombinant protein Reinfection SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 virus severe acute respiratory syndrome coronavirus 2 significantly spike mutations Transmissibility vaccination Vaccine Vaccines variant variants variants of concern variants of interest variants of SARS-CoV-2 VoC VOCs [DOI] 10.1017/S0950268821002430 PMC 바로가기 [Article Type] Review
Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 InfectionCOVID-19의 항체 반응 패턴 프로파일링: SARS-CoV-2 감염의 진화에서 스파이크 S1-반응성 IgA 서명Immunology Published on 2021-11-032022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody antibody level antibody production Antibody Response antigens baseline Characteristics Clinical course Clinical management clinical manifestations Clinical outcome Cohort coronavirus coronavirus disease COVID-19 COVID-19 patient detectable diagnosed driver dropped exhibiting First wave heterogeneous IgA IgG IgG level IgM Italy levels of antibodies long-lasting magnitude majority marker Neutralizing Neutralizing activity Neutralizing antibodies pandemic Patient pattern persistence Perspective predict Profiling reactive reflect response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 severity signature spike statistical subsequent the antibody response the disease the SARS-CoV-2 Vaccination strategies VoC [DOI] 10.3389/fimmu.2021.772239 PMC 바로가기 [Article Type] Immunology
Increased in vitro neutralizing activity of SARS-CoV-2 IgA1 dimers compared to monomers and IgG단량체 및 IgG에 비해 SARS-CoV-2 IgA1 이량체의 시험관 내 중화 활성 증가Article Published on 2021-11-022022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen antigen binding binding complex coronavirus exhibited expressed expression feature glycosylation homogeneous human proteins IgA IgG IgG1 in vitro Increased monoclonal monoclonal antibodies monomer Neutralizing activity neutralizing monoclonal antibodies neutralizing monoclonal antibody Nicotiana benthamiana plant plant expression plants respiratory SARS-CoV-2 SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus significantly increased variant Variation [DOI] 10.1073/pnas.2107148118 PMC 바로가기 [Article Type] Article
IgG Study of Blood Sera of Patients with COVID-19Article Published on 2021-11-022022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] affected affecting analyzed antibody antibody specificity Blood Comorbidity convalescent country COVID-19 COVID-19 pandemic cross-reactive antibody cross-reactivity death descending diagnosed with COVID-19 died disease disease severity ELISA Factor Frankfurt hospital humoral Humoral immunity IgG immunoblotting inactivated Infection levels of antibody median value neutralization neutralization test neutralize Neutralizing activity neutralizing antibody Patient presence of antibody RBD recombinant proteins SARS-CoV SARS-CoV antigen SARS-CoV-2 sera serum severity tested the N protein trimer Virus neutralization with COVID-19 Wuhan [DOI] 10.3390/pathogens10111421 PMC 바로가기 [Article Type] Article
Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy개선된 항-SARS-CoV-2 효능을 갖는 Fc-조작된 항체 치료제Article Published on 2021-11-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] activating administration anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody therapeutics antiviral immunity clinical benefit clinical benefits Clinical efficacy Complication COVID-19 COVID-19 disease demonstrated Disease model domain dose driving Effect Efficacy Fcγ receptor High dose highlight Hospitalization hospitalized patient hospitalized patients implication Infection Mild-to-moderate monoclonal antibodies monoclonal antibody Mortality Neutralizing activity pathogenic pathway preventing disease receptor receptor engagement reducing required risk SARS-CoV-2 SARS-COV-2 infection selective severe disease significantly Treatment treatment of COVID-19 weight loss with COVID-19 [DOI] 10.1038/s41586-021-04017-w PMC 바로가기 [Article Type] Article
Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients신장 이식 수혜자에서 3회 접종 COVID-19 mRNA 백신 요법의 안전성 및 교차 변이 면역원성Article Published on 2021-11-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] anti-Spike IgG antibody Antigen BNT162b2 BNT162b2 vaccine Cell cells cellular response Cellular responses COVID-19 COVID-19 vaccine cytokine cytokine production delta variant dose doses explained Frequency Heterologous homologous IFN-γ IFN-γ response IFN-γ responses IgG immunogenicity immunosuppressive immunosuppressive therapy increase interferon kidney Kidney function kidney transplant kidney transplant recipient longitudinal study Mild mRNA mRNA vaccine neutralization activity Neutralizing activity neutralizing antibody Nice University Hospital one patient Patient PBMC PBMCs performed raised reaction Reactions recipient recipients regimen remained Safety second dose Seroconversion seronegative significant increase spike-specific IgG tested therapy Tolerability university Vaccine variants variants of concern variants of concern, kidney transplantation. [DOI] 10.1016/j.ebiom.2021.103679 PMC 바로가기 [Article Type] Article
Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology뚜렷한 증상을 보이는 SARS-COV-2 감염 아동의 바이러스 및 면역학적 특징Article Published on 2021-11-012022-09-12 Journal: Pediatric allergy and immunology : official public [Category] MERS, SARS, 진단, [키워드] Ag-specific cellular response anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 humoral Asymptomatic asymptomatic patients CD8+ T cells CD8+T cells cellular cellular response children collected contribute demonstrated Diagnosis DiaSorin Epidemic evaluated expression faster feature Frequency humoral IgG immune response Immunity immunization immunological infected children Nasopharyngeal swab neutralization neutralization activity neutralization humoral activity Neutralizing activity Patient patients plasma protein pro-inflammatory Protein qPCR recruited risk SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 viral load stratified suggested symptomatic Symptomatic patients Symptoms to define vaccination Viral load Virological virus clearance virus load was performed WHO [DOI] 10.1111/pai.13585 PMC 바로가기 [Article Type] Article