proteomics – Page 27 – Communicable Diseases Research

Plasma Gradient of Soluble Urokinase-Type Plasminogen Activator Receptor Is Linked to Pathogenic Plasma Proteome and Immune Transcriptome and Stratifies Outcomes in Severe COVID-19

가용성 Urokinase-Type Plasminogen Activator Receptor의 혈장 구배는 병원성 Plasma Proteome 및 면역 전사체와 연결되어 심각한 COVID-19의 결과를 계층화합니다

Immunology

Published on 2021-10-282022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상,

Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19

조직 단백질 분석은 치명적인 covid-19에서 면역 병리학의 메커니즘과 단계를 식별합니다.

Original Research

Published on 2021-10-282022-09-10
Journal: American Journal of Respiratory Cell and Molecular [Category] COVID19(2023년), Fulltext, MERS, SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] abundance Activation Analysis Antiviral antiviral responses B-cell Cancer CD8A chemotactic factor Cluster colony stimulating factor component Control tissue coronavirus coronavirus disease correlated COVID-19 CSF-1 DDX58 death Deceased disease stages Donor Evidence Factor fatal COVID-19 Host IL-18 illness duration immunoassay immunopathology Inflammation lung lymphocyte Macrophage macrophages MCP-3 Meta-analysis Monocytes monocytes/macrophage Mortality multiplex occur organ Organ Donors OSM overlap parenchymal pathway Patient phenol plasma Plasma cells postmortem examination postmortem examinations proapoptotic factor proapoptotic factors profiles Protein proteomic proteomics prothrombotic provide provided pulmonary thrombosis quantification RAGE receptor signaling reduce required S100A12 severity spleen Stage subset therapeutic target therapy thrombosis tissue tissues TRIM21 TYMP Unsupervised clustering Viral Viral RNA was obtained were used
[DOI] 10.1165/rcmb.2021-0358OC PMC 바로가기 [Article Type] Original Research

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

항바이러스 약물 발견을 위한 SARS-CoV-2-호스트 프로테옴 상호작용

Article

Published on 2021-10-282022-09-10
Journal: Molecular Systems Biology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] addition Affinity purification analyses Analysis antiviral activity antiviral drug Antiviral effect antiviral effects applied approach biological significance candidate drug caused cofactor cofactors complementary Compound COVID‐19 criterion Critical develop downstream drug Drug discovery effective therapy Host host cell host cell proteases host protein host proteins hub protein identify in viral inhibitory effect Interaction labeling list mass spectrometry methotrexate Microbiology, Virology & Host Pathogen Interaction molecular ORF Pharmacology & Drug Discovery protein targets protein–protein interactions proteome proteomics provided receptors Replication resource SARS‐CoV‐2 SARS‐CoV‐2 suggested understanding Viral viral pathogenesis viral replication Virtual screening virus–host interactions
[DOI] 10.15252/msb.202110396 PMC 바로가기 [Article Type] Article

The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells

Microbiology

Published on 2021-10-282022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] Allicin Allium Antiviral ARHGAP17 Bacteria Calu-3 Calu-3 cell calu-3 cells caused cell cultures changes in CLTCL1 compounds decrease derivative dose Effect effector effectors exposure expression fungi Future greater GSH Host human cell IFI16 Ifi44 IFN signaling pathway immunomodulatory activity interferon-stimulated gene investigated ISG ISG15 low molecular weight metabolism Modification OAS ORF3 OSBPL2 pathway plant produced Protein proteome proteomics Quantitative reduced Research SARS-CoV-2 SARS-COV-2 infection stability tight junction tissue damage Tolerance Toxicity Transcription translation Treatment uninfected cells Vero E6 VERO E6 cells Vesicular Transport Viral particles Viral protein Viral RNA was used
[DOI] 10.3389/fmicb.2021.746795 PMC 바로가기 [Article Type] Microbiology

Proximity Extension Assay in Combination with Next-Generation Sequencing for High-throughput Proteome-wide Analysis

Research article

Published on 2021-10-272022-10-05
Journal: Molecular & Cellular Proteomics : MCP [Category] 비임상,

[키워드] antibody automated Biomarker contribute disease disease severity immunoassay information knowledge multiplex Next-generation sequencing Patient plasma Precision Prognosis progression Protein proteome proteomics proximity extension assay Sequencing serum Stratification translate understanding unique
[DOI] 10.1016/j.mcpro.2021.100168 [Article Type] Research article

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL pro substrate degradome

SARS-CoV-2 3CL pro 기질 분해에 대한 글로벌 분석을 통한 COVID-19에 대한 기계론적 통찰력

Article

Published on 2021-10-262022-09-12
Journal: Cell Reports [Category] MERS, SARS, 진단, 치료제,

[키워드] 3CL pro accelerate active site structure amplify Analysis bind binding Cell cleavage cleavage sites consequence COVID-19 degradomics drug design effector effector proteins global analysis glycoprotein healthy human lung identify inactivation interactome kidney lung Lungs MAP4K5 molecular docking mRNA pathology pathway Post-mortem protease Proteases Protein proteomics SARS-CoV SARS-CoV-2 SARS-CoV-2 3CL(pro) SARS-CoV-2 main protease SARS-CoV-2 replication SARS-CoV-2-infected cells specificity spike subsite specificity substrate substrates substrates. supported target the SARS-CoV-2 Transcription translation
[DOI] 10.1016/j.celrep.2021.109892 PMC 바로가기 [Article Type] Article

Induction of trained immunity by influenza vaccination – impact on COVID-19

인플루엔자 예방접종을 통한 훈련된 면역 유도 - 코로나19에 미치는 영향

Observational Study

Published on 2021-10-252022-09-10
Journal: PLoS Pathogens [Category] MERS, 유전자 메커니즘, 임상,

[키워드] affected anti-SARS-CoV-2 assays caused claimed COVID-19 COVID-19 incidence COVID-19 vaccine cross-protection decrease distribution Effects epidemiological Epidemiological study fine-tune flu healthcare worker help hospital identify Immune cell immune cells immune responses Immunity immunological inactivated induction Influenza influenza vaccination influenza vaccine innate immune response innate immune responses Innate immunity investigated less lower risk mechanism mind monocyte Monocytes observation pandemic potential benefit potential benefits protective effect proteomics randomized trial reduced Relative risk reported reveal risk reduction Safe SARS-CoV-2 SARS-COV-2 infection Seasonal influenza Single-cell RNA sequencing suggested systemic inflammation transcriptional vaccination vaccination against COVID-19 Vaccine variant Viral virus
[DOI] 10.1371/journal.ppat.1009928 PMC 바로가기 [Article Type] Observational Study

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein

Research Article

Published on 2021-10-222022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome Allotype allotypes Analysis analyzed antigen processing antigenic peptide antigenic peptides approach breadth Cell contribute Control coronavirus coronavirus disease COVID-19, coronavirus disease 19 Critical cytotoxic determinant Endoplasmic reticulum enzyme enzyme mechanism Epitopes ER, endoplasmic reticulum ERAP1 ERAP1, endoplasmic reticulum aminopeptidase 1 genetic variability glycoprotein hallmark heterogeneity histocompatibility complex HLA HLA, human leukocyte antigen immune response immune system gene Immunity individuals Infection Ligand mechanism MHC MHC, major histocompatibility complex Pathogens PCA, principal component analysis peptide peptides Population precursor produced producing Proteolytic processing proteomic proteomics PSM, peptide-spectrum match reaction regulate response SARS-CoV-2 S1 spike SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 sequence severity significant difference SNPs spike glycoprotein suggested T-lymphocyte trimming underlie vaccination Variability Variation while
[DOI] 10.1016/j.jbc.2021.101329 PMC 바로가기 [Article Type] Research Article

Dried blood sample analysis by antibody array across the total testing process

Article

Published on 2021-10-152022-10-04
Journal: Scientific Reports [Category] 바이오마커,

The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children

소아에서 과염증성 다기관 염증 증후군의 자가면역 시그니처

Article

Published on 2021-10-152022-09-11
Journal: The Journal of Clinical Investigation [Category] 바이오마커, 유전자 메커니즘,

[키워드] Admission Analysis anti-Spike IgG antigenic antigens autoantibodies autoantibody autoantigen Autoimmune Autoimmune diseases Autoimmunity B cell BCR Cellular immune response children Cluster Coagulation coagulation pathways Combination complement contributing to COVID-19 Cytokines expressed Factor Genes heavy chain humoral immune responses Hyperinflammatory identify IgG IGHV immune immune responses Immunoglobulin Immunopathogenesis Inflammation inflammation markers Inflammatory Inflammatory response intensive care intensive care unit admission manifestation Mild MIS-C Multiorgan neutrophil neutrophil activation neutrophil response pathogenic pathway Patient Previous studies previous study proteomics receptor RNA sequencing SARS-COV-2 infection sequence Sequencing serum superantigen syndrome T cell T cell receptor TCR tissue damage TRBV11-2 Treatment Usage variable region
[DOI] 10.1172/JCI151520 PMC 바로가기 [Article Type] Article