Computational Insights Into the Effects of the R190K and N121Q Mutations on the SARS-CoV-2 Spike Complex With BiliverdinMolecular Biosciences Published on 2021-12-132022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] addition antibody Biliverdin binding binding site cause conducted conformational change COVID-19 Effect Hydrogen bond hydrogen bonds indicated insight Interaction MM/GBSA calculation molecular Molecular dynamics simulation molecular mechanism mutant mutants Mutation mutations promoted SARS-CoV-2 spike significantly spike the binding affinity the SARS-CoV-2 wild-type [DOI] 10.3389/fmolb.2021.791885 PMC 바로가기 [Article Type] Molecular Biosciences
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal세네갈에서 SARS-CoV-2 스파이크 수용체 결합 도메인 변이체의 새로운 조합의 출현Article Published on 2021-12-082022-09-10 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Combination coronavirus Course Diseases E484K emergence escape mutation Evidence evidence of Evolution genetics genomes Health care L452R Lineage lineages Local MONITOR Mutation mutations N501Y new SARS-CoV-2 next generation sequencing pandemic parallel evolution Receptor binding domain respiratory S477N SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike mutations second wave sequence sequenced Sequencing severe acute respiratory syndrome Coronavirus specimen specimens spike gene Treatment variant whole genome [DOI] 10.1038/s41598-021-02874-z PMC 바로가기 [Article Type] Article
Iota-Carrageenan Inhibits Replication of SARS-CoV-2 and the Respective Variants of Concern Alpha, Beta, Gamma and DeltaIota-Carrageenan은 SARS-CoV-2 및 우려되는 알파, 베타, 감마 및 델타의 각 변종 복제를 억제합니다Article Published on 2021-12-082022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 치료제, [키워드] age Alpha antiviral activity Antiviral effect Beta Calu Calu-3 can not carrageenan carrageenan types Carrageenans comparable concern contribute coronavirus COVID-19 COVID-19 pandemic Defense Delta effective exhibit Gamma human lung cell human lung cells independent independent of infect Infection inhibit investigated Iota iota-carrageenan kappa-carrageenan lack Lambda lambda-carrageenan lentivirus nasal Particle Prophylaxis pseudotyped pseudotyping public health threat reduce SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike Spread SSPL sulfated polymer sulfated polysaccharide sulfated polysaccharides supply the SARS-CoV-2 TMPRSS2 transgenic transmission of SARS-CoV-2 transmitted Treatment vaccination Vaccine Vaccine-induced immunity variants variants of concern Viral Viral transmission virulent virus variants VoC VOCs Wuhan [DOI] 10.3390/ijms222413202 PMC 바로가기 [Article Type] Article
From Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immune Response to Cancer Onset via Molecular Mimicry and Cross-ReactivityOriginal Article Published on 2021-12-072022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] acute respiratory syndrome analyzed Antigen Autoimmune Cancer cancer epidemic coronavirus coronavirus 2 cross-reactive cross-reactivity database described Epitopes individual Long COVID material mimicry molecular molecular mimicry objective Onset overlap pandemic pathogen pentapeptide peptide potential mechanism Protein Proteins question respiratory response Result retrieved risk SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike gp Support Surveillance tumor-suppressor proteins tumors UniProt Viral antigen virus [DOI] 10.1055/s-0041-1735590 PMC 바로가기 [Article Type] Original Article
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients경증 COVID-19 환자에서 공개 cTfh 클론형을 확장하는 보존된 SARS-CoV-2 스파이크 에피토프 식별Article Published on 2021-12-062022-09-11 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 진단, [키워드] activate activated T cell activated T cells activating Adaptive immunity Antigen booster CD4+ T cell CD4+ T cells Cell characterized circulating commensal bacteria conserved COVID-19 epitope Epitopes expand follicular healthy donors HLA identification mild COVID-19 patient mild symptoms Patient prevalent Protective protective antibodies SARS-CoV-2 epitopes SARS-CoV-2 S SARS-CoV-2 spike subset T cell T cells TCR TCRs Tfh Tfh cell Tfh cells the SARS-CoV-2 variants [DOI] 10.1084/jem.20211327 PMC 바로가기 [Article Type] Article
A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concernBrief Communication Published on 2021-12-032022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] alleviate B.1.1.7 B.1.351 B.1.617.2 Beta combating COVID-19 COVID-19 pandemic Delta effective Efficacy Gamma immunization IMPROVE mice neutralization Neutralizing antibody titer non-human primates P.1 Protein vaccines reduced SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant sequence shown South Africa spike vaccination Vaccinations Vaccine variant VoC Wuhan [DOI] 10.1038/s41541-021-00411-7 PMC 바로가기 [Article Type] Brief Communication
Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2Article Published on 2021-12-022022-10-04 Journal: Communications Biology [Category] SARS, 바이오마커, [키워드] binding CD8 competent coronavirus cross-reactive cross-reactivity Cytotoxic T cell detectable dominant epitope donors epitope exhibited functional healthy donor Hematological malignancy identification identify immunodominant epitope immunodominant epitopes Immunological memory Immunosuppressed Patient reduced SARS-CoV-2 SARS-CoV-2 spike selected selective Shimizu single-cell level stimulated T cell T cell receptors T-cell receptor TCR the SARS-CoV-2 Vaccine development viral infection [DOI] 10.1038/s42003-021-02885-6 PMC 바로가기 [Article Type] Article
Reinfection with new variants of SARS-CoV-2 after natural infection: a prospective observational cohort in 13 care homes in EnglandObservational Study Published on 2021-12-012022-10-05 Journal: The Lancet. Healthy longevity [Category] SARS, 변종, 임상, 진단, [키워드] Alpha Antigen binding Care Concentration COVID-19 vaccination Cox proportional hazard diagnostic Effectiveness eight England FIVE Follow-up follow-up period groups had no individual infected individual infected individuals Kinetics Lateral flow device London national guidelines natural infection Neutralising activity neutralising antibody nose and throat occurred Older participant Poisson regression positive Positive test Primary infection Primary outcome prospective observational cohort protection Protective Public recruited Reinfection required risk RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RT-PCR SARS-CoV-2 spike Serological testing staff Surveillance susceptible individual sustained swab sample symptomatic individuals tested timepoint titre transmissible variants understanding variant variants of SARS-CoV-2 were assessed were used [DOI] 10.1016/S2666-7568(21)00253-1 PMC 바로가기 [Article Type] Observational Study
Fiber-optic label-free biosensor for SARS-CoV-2 spike protein detection using biofunctionalized long-period fiber grating생체 기능화된 장기 섬유 격자를 사용한 SARS-CoV-2 스파이크 단백질 검출을 위한 광섬유 라벨이 없는 바이오센서Article Published on 2021-12-012022-09-11 Journal: Talanta [Category] SARS, 치료기술, [키워드] ambient ambient temperature antibody caused changes in concentrations coronavirus COVID-19 demonstrated detect develop diagnostic methods exhibited faster fiber Local Long-period fiber grating MERS-CoV Modification offer optical phase Phase shift protein concentration refractive index SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein Spike protein stability surface surface functionalization temperature transport medium Variation variations virus transport medium widespread [DOI] 10.1016/j.talanta.2021.122801 PMC 바로가기 [Article Type] Article
Performance of the T-SPOT Ⓡ.COVID test for detecting SARS-CoV-2-responsive T cellsSARS-CoV-2 반응성 T 세포 검출을 위한 T-SPOT Ⓡ.COVID 검사 성능Article Published on 2021-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, 치료법, [키워드] Activation Adaptive immune response anti-N IgG Blood common cold common cold coronavirus control group coronavirus COVID-19 cross-reactive detect Diagnosis ELISPOT evaluate IGRA Immunoglobulin Infection interferon interferon-gamma release assay less methodology NAAT nucleic acid nucleic acid amplification nucleic acid amplification test nucleocapsid participant Participants participants with SARS-CoV-2 Patient peptides performance performed reactive response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serology serology test seropositive T cell T cell response T cell responses T cells T-cell T-cells T-SPOT.COVID [DOI] 10.1016/j.ijid.2021.09.073 PMC 바로가기 [Article Type] Article