Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19 Research Published on 2020-11-302022-10-05 Journal: Nature Neuroscience [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome appear Brain cause Central nervous system CNS coronavirus COVID-19 defined described endothelial Evidence individuals with COVID-19 Infarction Infection Invasion majority means morphological change mucosa mucosal nasopharynx nervous system Neurological symptom oblongata olfactory pandemic Penetrating Protein Region Respiratory disease SARS-CoV-2 SARS-CoV-2 neurotropism SARS-CoV-2 RNA structures thromboembolic Thromboembolic event tissue [DOI] 10.1038/s41593-020-00758-5 [Article Type] Research
Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidateReport Published on 2020-11-272022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, [키워드] acute respiratory syndrome Analysis complexes coronavirus coronavirus disease COVID-19 ectodomain effort full-length full-length SARS-CoV-2 full-length spike protein host immune system immune response Interaction Microscopy Modification Neutralizing antibodies Novavax pandemic performed prefusion conformation provide responsible reveal SARS-CoV-2 SARS-CoV-2 spike glycoprotein Science Spike protein spike trimers stability Structure structures subunit the S1 subunit the vaccine Trimeric spike protein Vaccine vaccine candidate Vaccine development virus [DOI] 10.1126/science.abe1502 PMC 바로가기 [Article Type] Report
DPL: a comprehensive database on sequences, structures, sources and functions of peptide ligandsDatabase Tool Published on 2020-11-202022-11-01 Journal: Database: The Journal of Biological Databases and [Category] Coronavirus, SARS, [키워드] 3D structure anticancer Antiviral binding collected coronavirus COVID-2019 database Epidemic function I-TASSER include Ligand linear MOST PDB peptide peptides platform predicted protease inhibitors provide receptor Research resource SARS-CoV-2 sequence Structure structures targets unique [DOI] 10.1093/database/baaa089 PMC 바로가기 [Article Type] Database Tool
Key Considerations for Successful Risk Communication and Community Engagement (RCCE) Programmes During COVID-19 Pandemic and Other Public Health EmergenciesViewpoint Published on 2020-11-172022-10-27 Journal: Annals of Global Health [Category] Coronavirus, SARS, [키워드] activities activity affected communication Community COVID-19 disease transmission Emergency Engagement health information Local measure Other protective behaviour Public public health emergency Structure structures [DOI] 10.5334/aogh.3119 PMC 바로가기 [Article Type] Viewpoint
A 3.4-Å cryo-electron microscopy structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particlesResearch Article Published on 2020-11-172022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] ACE2 activating addition antibody binding biochemically cause children coronavirus Cryo-electron microscopy cryo-EM domain drugs ectodomain explain family Coronaviridae glycosylation HCoV-NL63 homologous Human human coronavirus NL63 immunocompromised individuals Mild NL63 Particles pathogen provide purified receptor receptors respiratory diseases Respiratory illness S trimer SARS-CoV-1 SARS-CoV-2 shown Spike protein spike trimer Spread structures trimer upper respiratory symptom viral entry virion virus particle [DOI] 10.1017/qrd.2020.16 PMC 바로가기 [Article Type] Research Article
Surgical management of oncologic patient during and after the COVID-19 outbreak: practical recommendations from the Italian society of Surgical OncologyOriginal Article Published on 2020-11-122022-10-29 Journal: Updates in surgery [Category] COVID-19, MERS, [키워드] acquisitions addressed aggressiveness board calibrated Cancer cancer patient caused Course COVID-19 COVID-19 pandemic Critical cured diffusion effort Evidence Follow-up health regulation health system hospital Infection invasive Italian Italy limit management multidisciplinary discussion not affect oncologic surgery oncology outbreak pandemic pathway Patient PPE Prognosis protocol recommendation recommendations reduce resource risk Society Specific Spread structures subject therapeutic therapy training Tumor [DOI] 10.1007/s13304-020-00921-4 PMC 바로가기 [Article Type] Original Article
A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methodsReview Published on 2020-11-032022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] 3CLpro Abstract Anti-viral antibiotic applied binding biological activity candidate cause caused complexes computational method COVID-19 pandemic cysteine protease derivatives drug drug-repurposing functional generate identify imperative in silico in silico Approach Infection information inhibit inhibitor inhibitors interacting residues interaction pattern intermolecular interaction Ligand-based virtual screening (LBVS) ligand-bound molecular nucleotide analogues parameter peptides potential therapeutic agent protease protease inhibitors Proteins provide replicase polyprotein SARS-CoV-2 shown stability Structure Structure-based virtual screening (SBVS) structures therapeutic viral replication Virtual screening virulent virus [DOI] 10.1186/s43141-020-00085-z PMC 바로가기 [Article Type] Review
How would you like your COVID-19? From a host with mild course disease, or from a severe one?Case report Published on 2020-11-012022-10-05 Journal: The American journal of emergency medicine [Category] 유전자 메커니즘, [키워드] affecting age Asymptomatic case sery chronic disease Clinical course composed Course COVID-19 disease evaluated Factor Genetic hospital Host Host factor in COVID-19 individual individuals Laboratory Mild Mortality Novel coronavirus Other radiological finding resulting SARS-CoV-2 Seven Source of coronavirus structures Subtypes of novel coronavirus the disease Transmission were infected [DOI] 10.1016/j.ajem.2020.05.091 [Article Type] Case report
Escape from neutralizing antibodies by SARS-CoV-2 spike protein variantsSARS-CoV-2 스파이크 단백질 변이체에 의한 중화 항체로부터의 탈출Research Article Published on 2020-10-282022-09-10 Journal: eLife [Category] MERS, SARS, 변종, 진단, [키워드] activate addressed Administered Analysis anti-SARS-CoV-2 antibodies antibody antibody combination antibody-based therapies antibody-based therapy Blood blood plasma cause Cell cells changed chimeric circulating Combination convalescent plasma coronavirus COVID-19 COVID19 creating effective vaccine Effective vaccines Effectiveness effort elicited eLife Epitopes escape evade Frequency functional Genome Health HIV host cells Human human cells human population human populations immune immune response immune system in some individual infect Infection Influenza kill Laboratory limit low frequencies maintain monoclonal antibodies monoclonal antibody mutant mutant virus mutate mutated Mutation N-terminal domain natural infection neutralize Neutralizing antibodies neutralizing antibody neutralizing epitopes New coronavirus Patient Population populations Prevent produced Prophylactic Proteins question RBD Receptor-binding domain Recovered COVID-19 patients reporter Research SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV-2 variant selected Sequencing Spike protein Spike proteins Structure structures target the antibody the disease the receptor-binding domain the SARS-CoV-2 the spike protein the strongest therapeutic Therapies treated Trigger vaccination Vaccine Vaccines variant Viral protein Viral proteins virus virus mutation virus particle virus particles viruses VSV were infected [DOI] 10.7554/eLife.61312 PMC 바로가기 [Article Type] Research Article
Phytogenic Products and Phytochemicals as a Candidate Strategy to Improve Tolerance to CoronavirusVeterinary Science Published on 2020-10-202022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] acute respiratory syndrome antiviral activities antiviral activity Antiviral compound bronchitis caffeic acid candidate carried caused compounds Concentration coronavirus coronavirus disease Coronaviruses cough COVID-19 COVID-19 pandemic death Fever fused Health herbal medicine humans IBV Immunity include Infection Infectious disease influences on inhibit inhibitor inhibitory knowledge lack majority medication MERS Middle East negative influence outbreak phytochemical phytochemicals phytogenic additive plants plasma polar product proliferation quercetin researcher SARS-CoV-2 Side effects small molecule sore throat spread of COVID-19 strain Strategy structures Symptom syndrome Treatment viral infections virus with COVID-19 [DOI] 10.3389/fvets.2020.573159 PMC 바로가기 [Article Type] Veterinary Science